Continuous infusion of gentamicin into the tarsocrural joint of horses

American Journal of Veterinary Research

Volumn 61, Issue 4, 2000, Pages 407-412

  Lescun, Timothy B ^a   Adams, Stephen B ^a   Wu, Ching Ching ^a   Bill, Robert P ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENTAMICIN;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL ARTHRITIS; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SYNOVIAL FLUID LEVEL; FEMALE; HORSE; MALE; NONHUMAN; TARSAL JOINT;

ANIMALIA; BACTERIA (MICROORGANISMS); EQUIDAE; EQUUS CABALLUS;

EID: 0034100960     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2000.61.407     Document Type: Article

References (26)

1. Schneider RK, Bramlage LR, Mecklenburg LM, et al. Open drainage, intra-articular and systemic antibiotics in the treatment of septic arthritis/tenosynovitis in horses. Equine Vet J 1992;24:443-449.
2. Hague BA, Carter GK. Diseases of multiple bones and joints; inflammatory, infectious and immune diseases. In: Colahan PT, Mayhew IG, Merritt AM, et al, eds. Equine medicine and surgery. 5th ed. St Louis: Mosby Inc, 1999; 1447-1454.
3. McIlwraith CW. Treatment of infectious arthritis. Vet Clin North Am Large Anim Pract 1983;5:363-379.
4. Bertone AL. Infectious arthritis. In: McIlwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Co, 1994;397.
5. Esterhai JL, Gelb I. Adult septic arthritis. Orth Clin North Am 1991;22:503-514.
6. Moore RM, Schneider RK, Kowalski J, et al. Antimicrobial susceptibility of bacterial isolates from 233 horses with musculoskeletal infection during 1979-1989. Equine Vet J 1992,24:450-456.
7. Schneider RK, Bramlage LR, Moore RM, et al. A retrospective study of 192 horses affected with septic arthritis/tenosynovitis. Equine Vet J 1992;24:436-442.
8. Godber LM, Walker RD, Stein GE, et al. Pharmacokinetics, nephrotoxicosis, and in vitro antibacterial activity associated with single versus multiple (three times) daily gentamicin treatments in horses. Am J Vet Res 1995;56:613-618.
9. Jackson GG, Lolans VT, Daikos GL. The inductive role of ionic binding in the bactericidal and postexposure effects of aminoglycoside antibiotics with implications for dosing. J Infect Dis 1990;162: 408-413.
10. Moore RD, Leiman PS, Smith CR. Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Inject Dis 1987;155:93-99.
11. Lloyd KCK, Stover SM, Pascoe JR, et al. Plasma and synovial fluid concentrations of gentamicin in horses after intraarticular administration of buffered and unbuffered gentamicin. Am J Vet Res 1988;49:644-649.
12. Sojka JE, Brown SA. Pharmacokinetic adjustment of gentamicin dosing in horses with sepsis. J Am Vet Med Assoc 1986;189:784-789.
13. Gilman AG, Goodman LS, Rall TW, et al. Goodman and Gilman's the pharmacologic basis of therapeutics. 7th ed. New York: MacMillan Publishing Co, 1985;1154-1155.
14. Lloyd KCK, Stover SM, Pascoe JR, et al. Synovial fluid pH, cytologic characteristics, and gentamicin concentration after intraarticular administration of the drug in an experimental model of infectious arthritis in horses. Am J Vet ReS 1990;51:1363-1369.
15. Whitehair KJ, Blevins WE, Fessler JF, et al. Regional perfusion of the equine carpus for antibiotic delivery. Vet Surg 1992;21: 279-285.
16. Whitehair KJ, Bowersock TL, Blevins WE, et al. Regional limb perfusion for antibiotic treatment of experimentally induced septic arthritis. Vet Surg 1992;21:367-373.
17. Shargel L, Yu ABC. Intravenous infusion. In: Shargel L, Yu ABC, eds. Applied biopharmaceutics and pharmacokinetics. 3rd ed. Stamford: Appleton and Lange, 1993;335-352.
18. Shargel L, Yu ABC. Review of mathematical fundamentals. In: Shargel L, Yu ABC, eds. Applied biopharmaceutics and pharmacokinetics. 3rd ed. Stamford: Appleton and Lange, 1993;6-7.
19. Orsini JA, Spencer E. Epidemiology of aminoglycoside resistance in a large animal hospital. Equine Vet J 1997;29:319-321.
20. Thal LA, Chow JW, Mahayni R, et al. Characterization of antimicrobial resistance in enterococci of animal origin. Antimicrob Agents Chemotherap1995;39:2112-2115.
21. Daikos GL, Jackson GG, Lolans VT, et al. Adaptive resistance to aminoglycoside antibiotics from first-exposure downregulation. J Infect Dis 1990;162:414-420.
22. Stover SM, Pool RR. Effect of intra-articular gentamicin sulfate on normal equine synovial membrane. Am J Vet Res 1985;46:2485-2491.
23. Wagner AE, McIlwraith CW, Martin GS. Effect of intraarticular injection of orgotein and saline solution on the equine synovia. Am J Vet Res 1982;43:594-597.
24. Adair HS, Goble DO, Vanhooser S, et al. Evaluation of use of dimethyl sulfoxide for intraarticular lavage in clinically normal horses. Am J Vet Res 1991;52:333-336.
25. Bertone AL, McIlwraith CW, Powers BE, et al. Effect of four antimicrobial lavage solutions on the tarsocrural joint of horses. Vet Surg 1986;15:305-315.
26. Todhunter PG, Kincaid SA, Todhunter RJ, et al. Immunohistochemical analysis of an equine model of synovitis-induced arthritis. Am J Vet Res 1996;57:1080-1093.