Pharmacological assessment of adrenergic receptors in human varicose veins

International Angiology

Volumn 19, Issue 2, 2000, Pages 176-183

  Miller, V M ^a   Rud, K S ^a   Gloviczki, P ^a  

^a MAYO CLINIC   (United States)

Author keywords

Norepinephrine; Receptor, adrenergic alpha2; Receptors, adrenergic alpha1; Saphenous vein

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; NORADRENALIN; RUSCUS EXTRACT;

ADULT; AGED; ARTERY RECONSTRUCTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; MALE; MUSCLE ISOMETRIC CONTRACTION; RECEPTOR DENSITY; SAPHENOUS VEIN; SMOOTH MUSCLE CONTRACTION; VARICOSIS;

ADRENERGIC ALPHA-AGONISTS; AGED; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NOREPINEPHRINE; PLANT EXTRACTS; RECEPTORS, ADRENERGIC, ALPHA; SAPHENOUS VEIN; VARICOSE VEINS; VASOCONSTRICTION;

EID: 0034098345     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Sansilvestri-Morel P, Nonotte I, Fournet-Bourguignon MP, Rupin A, Fabiani J-N, Verbeuren TJ et al. Abnormal deposition of extracellular matrix proteins by cultured smooth muscle cells from human varicose veins. J Vasc Res 1998;35:115-23.
2. Bouissou H, Julian M, Pieraggi M-T, Maurel E, Thiers J-C, Louge L. Structure of healthy and varicose veins. In: Vanhoutte PM, editor. Return circulation and norepinephrine: an update. Paris: John Libbey Eurotext, 1991: 139-50.
3. Bouissou H, Julian M, Pieraggi M-T, Louge L. Vein morphology. Phlebology 1988; 3:1-11.
4. Thulesius O, Ugaily-Thulesius L, Gjores JE, Neglen P. The varicose saphenous vein, functional and ultrastructural studies, with special reference to smooth muscle. Phlebology 1988; 3:89-95.
5. Lowell RC, Gloviczki P, Miller VM. In vitro evaluation of endothelial and smooth muscle function of primary varicose veins. J Vasc Surg 1992; 16:679-86.
6. Blochl-Daum B, Schuller-Petrovic S, Wolzt M, Korn A, Bohler K, Eichler H-G. Primary defect in α-adrenergic responsiveness in patients with varicose veins. Clin Pharmacol Ther 1991; 49:49-52.
7. Schuller-Petrovic S, Siedler S, Kern T, Meinhart J, Schmidt K, Brunner F. Imbalance between the endothelial cell-derived contracting factors prostacyclin and angiotensin II and nitric oxide/cyclic GMP in human primary varicosis. Br J Pharmacol 1997;122:772-8.
8. Barker JE, Bakhle YS, Anderson J, Treasure T, Piper PJ. Reciprocal inhibition of nitric oxide and prostacyclin synthesis in human saphenous vein. Br J Pharmacol 1996; 118:643-8.
9. Haynes DF, Kerstein MD, Roberts MP, Bell WH, III, Rush DS, Kadowitz PJ et al. Increased prostacyclin and thromboxane A2 formation in human varicose veins. J Surg Res 1990;49:228-32.
10. Sinzinger H, Fitscha P. Prostacyclin (PGI2) contracts normal and varicose human saphenous veins. Vasa 1984; 13:228-30.
11. Monteil-Seurin J. Value of Ruscus in gyneacological pathology: 25 years of use in private practice. Phlebology 1988;3:87-98.
12. Boccalon H, Causse C, Yubero L. Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study. Int Angiol 1998;17:155-60.
13. Cluzan RV, Alliot F, Ghabboun S, Pascot M. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29:29-35.
14. Le Devehat C, Khodabandehlou T, Vimeux M. Evaluation of haemorheological and microcirculatory disturbances in chronic venous insufficiency: Activity of Daflon 500 mg. Int J Microcirc Clin Exp 1997;1:27-33.
15. Pecking AP, Fevrier B, Wargon C, Pillion G. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology 1997;48:93-8.
16. Juteau N, Bakri F, Pomies JP, Foulon C, Rigaudy P, Pillion G et al. The human saphenous vein in pharmacology: Effect of a new micronized flavonoidic fraction (Daflon 500 mg) on norepinephrine induced contraction. Int Angiol 1995;14:8-13.
17. Miller VM, Marcelon G, Vanhoutte PM. Ruscus-extract releases endothelium-derived relaxing factor in arteries and veins. In: Vanhoutte PM, editor. Return circulation and norepinephrine: an update. Paris: John Libbey Eurotext, 1991:31-42.
18. Miller VM, Rud K, Gloviczki P. Interactions of Ruscus-extract with endothelin-receptors in human varicose veins. Clin Hemorheol 1994; 14:S37-S45.
19. Rubanyi G, Marcelon G, Vanhoutte PM. Effect of temperature on the responsiveness of cutaneous veins to the extract of Ruscus aculeatus. Gen Pharmacol 1984;15: 431-4.
20. Marcelon G, Verbeuren TJ, Lauressergues H, Vanhoutte PM. Effect of Ruscus aculeatus on isolated canine cutaneous veins. Gen Pharmacol 1983;14:103-6.
21. Nemcova S, Gloviczki P, Rud KS, Miller VM. Cyclic nucleotides and production of prostanoids in human varicose veins. J Vasc Surg, 1999, in press.
22. Barber DA, Wang X, Gloviczki P, Miller VM. Characterization of endothelin receptors in human varicose veins. J Vasc Surg 1997; 26:61-9.
23. Flavahan NA, Vanhoutte PM. Receptor-reserve and heterogeneity of vascular responses to vasodilator stimuli. In: Vanhoutte PM, editor. Mechanisms of vasodilitation. New York: Raven Press, 1988:201-10.
24. Rizzi A, Quaglio D, Vasquez G et al. Effects of vasoactive agents in healthy and diseased human saphenous veins. J Vasc Surg 1998;28:855-61.
25. Thulesius O, Said S, Shuhaiber H, Neglen P, Gjores JE. Endothelial mediated enhancement of noradrenaline induced vasoconstriction in normal and varicose veins. Clin Physiol 1991;11:153-9.
26. Kiesewetter H, Scheffler P, Jung F, Schwab J, Blume J, Gerhards M. Effect of Ruscus extract in chronic venous insufficiency stage I, II and III. In: Vanhoutte P M. Return Circulation and norepinephrine: An update. Paris: John Libbey Eurotext, 1991:163-9.
27. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells. Chem Pharm Bull 1998;46:298-303.
28. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells. Phytochemistry 1998;48:485-93.