Pathophysiology of childhood obstructive sleep apnea: Current concepts

Respiration Physiology

Volumn 119, Issue 2-3, 2000, Pages 143-154

  Marcus, Carole L ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Apnea, obstructive, sleep; Control of breathing, ventilatory drive, sleep; Development, childhood; Mammals, humans; Sleep, obstructive apnea; Upper airways, patency

Indexed keywords

CONFERENCE PAPER; HUMAN; HYPERTROPHY; LUNG VENTILATION; MOTOR ACTIVITY; NEUROPATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATION CONTROL; SLEEP APNEA SYNDROME; TONSIL DISEASE;

ADULT; AGING; CHILD; HUMANS; SLEEP APNEA, OBSTRUCTIVE;

EID: 0034094027     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0034-5687(99)00109-7     Document Type: Conference Paper

References (71)

1. Ali N.J., Pitson D.J., Stradling J.R. Snoring, sleep disturbance and behaviour in 4-5 year olds. Arch. Dis. Child. 68:1993;360-366.
2. Aljadeff G., Gozal D., Schechtman V.L., Burrell B., Harper R.M., Ward S.L. Heart rate variability in children with obstructive sleep apnea. Sleep. 20:1997;151-157.
3. American Thoracic Society, 1996. Standards and indications for cardiopulmonary sleep studies in children. Am. J. Respir. Crit. Care. Med. 153, 866-878.
4. Aronson R.M., Onal E., Carley D.W., Lopata M. Upper airway and respiratory muscle responses to continuous negative airway pressure. J. Appl. Physiol. 66:1989;1373-1382.
5. Bayadi S.E., Millman R.P., Tishler P.V., Rosenberg C., Saliski W., Boucher M.A., Redline S. A family study of sleep apnea. Chest. 98:1990;554-559.
6. Benlloch E., Cordero P., Morales P., Soler J.J., Macian V. Ventilatory pattern at rest and response to hypercapnic stimulation in patients with obstructive sleep apnea syndrome. Respiration. 62:1995;4-9.
7. 2 with long-term CPAP therapy for obstructive sleep apnea. Am. Rev. Respir. Dis. 135:1987;144-147.
8. Bradley T.D., Phillipson E.A. Pathogenesis and pathopysiology of the obstructive sleep apnea syndrome. Med. Clin. North Am. 69:1985;1169-1185.
9. Brouillette R.T., Thach B.T. A neuromuscular mechanism maintaining extrathoracic airway patency. J. Appl. Physiol. 46:1979;772-779.
10. Busby K.A., Mercier L., Pivik R.T. Ontogenetic variations in auditory arousal threshold during sleep. Psychophysiology. 31:1994;182-188.
11. Carroll J.L., McColley S.A., Marcus C.L., Curtis S., Loughlin G.M. Inability of clinical history to distinguish primary snoring from obstructive sleep apnea syndrome in children. Chest. 108:1995;610-618.
12. Douglas N.J., Luke M., Mathur R. Is the sleep apnoea/hypopnoea syndrome inherited? Thorax. 48:1993;719-721.
13. Fernbach S.K., Brouillette R.T., Riggs T.W., Hunt C.E. Radiologic evaluation of adenoids and tonsils in children with obstructive apnea: plain films and fluoroscopy. Pediatr. Radiol. 13:1983;258-265.
14. Frank Y., Kravath R.E., Pollak C.P., Weitzman E.D. Obstructive sleep apnea and its therapy; clinical and polysomnographic manifestations. Pediatrics. 71:1983;737-742.
15. Garay S.M., Rapoport D., Sorkin B., Epstein H., Feinberg I., Goldring R.M. Regulation of ventilation in the obstructive sleep apnea syndrome. Am. Rev. Respir. Dis. 124:1981;451-457.
16. Gislason T., Benediktsdottir B. Snoring, apneic episodes, and nocturnal hypoxemia among children 6 months to 6 years old. Chest. 107:1995;963-966.
17. Gleadhill I.C., Schwartz A.R., Schubert N., Wise R.A., Permutt S., Smith P.L. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am. Rev. Respir. Dis. 143:1991;1300-1303.
18. Goh D.Y.T., Marcus C.L. Changes in obstructive sleep apnea characteristics in children through the night. Am. J. Respir. Crit. Care Med. 157:1998;A533.
19. Gozal D., Arens R., Omlin K.J., Marcus C.L., Keens T.G. Maturational differences in step vs. ramp hypoxic and hypercapnic ventilatory responses. J. Appl. Physiol. 76:1994;1968-1975.
20. Gozal D., Arens R., Omlin K.J., Ben-Ari G., Aljadeff G., Harper R.M., Keens T.G. Ventilatory response to consecutive short hypercapnic challenges in children with obstructive sleep apnea. J. Appl. Physiol. 79:1995;1608-1614.
21. Gozal D., Omidvar O., Kirlew K.A.T., Hathout G.M., Hamilton R., Lufkin R.B., Harper R.M. Identification of human brain regions underlying responses to resistive inspiratory loading with functional magnetic resonance imaging. Proc. Natl. Acad. Sci. USA. 92:1995;6607-6611.
22. Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics. 102:1998;616-620.
23. Greenberg H.E., Scharf S.M. Depressed ventilatory load compensation in sleep apnea. Reversal by nasal CPAP. Am. Rev. Respir. Dis. 148:1993;1610-1615.
24. Guilleminault C., Eldridge F.L., Simmons F.B., Dement W.C. Sleep apnea in eight children. Pediatrics. 58:1976;23-30.
25. 2 after tracheostomy in obstructive sleep apnea syndrome. Am. Rev. Respir. Dis. 126(1):1982;14-20.
26. Guilleminault C., Partinen M., Praud J.P., Quera-Salva M.A., Powell N., Riley R. Morphometric facial changes and obstructive sleep apnea in adolescents. J. Pediatr. 114(6):1989;997-999.
27. Guilleminault C., Partinen M., Hollman K., Powell N., Stoohs R. Familial aggregates in obstructive sleep apnea syndrome. Chest. 107:1995;1545-1551.
28. Henke K.G., Badr M.S., Skatrud J.B., Dempsey J.A. Load compensation and respiratory muscle function during sleep. J. Appl. Physiol. 72:1992;1221-1234.
29. Hudgel D.W., Hendricks C., Dadley A. Alteration in obstructive apnea pattern induced by changes in oxygen- and carbon-dioxide-inspired concentrations. Am. Rev. Respir. Dis. 138:1988;16-19.
30. Isono S., Remmers J.E., Tanaka A., Sho Y., Sato J., Nishino T. Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J. Appl. Physiol. 82:1997;1319-1326.
31. Isono S., Shimada A., Utsugi M., Konno A., Nishino T. Comparison of static mechanical properties of the passive pharynx between normal children and children with sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 157:1998;1204-1212.
32. Jeans W.D., Fernando D.C.J., Maw A.R., Leighton B.C. A longitudinal study of the growth of the nasopharynx and its contents in normal children. Br. J. Radiol. 54:1981;117-121.
33. Khan Y., Heckmatt J.Z. Obstructive apnoeas in Duchenne muscular dystrophy. Thorax. 49:1994;157-161.
34. Kunitomo F., Kimura H., Tatsumi K., Okita S., Tojima H., Kuriyama T., Honda Y. Abnormal breathing during sleep and chemical control of breathing during wakefulness in patients with sleep apnea syndrome. Am. Rev. Respir. Dis. 139:1989;164-169.
35. Laurikainen E., Erkinjuntti M., Alihanka J., Rikalainen H., Suonpaa J. Radiological parameters of the bony nasopharynx and the adenotonsillar size compared with sleep apnea episodes in children. Int. J. Pediatr. Otorhinolaryngol. 12:1987;303-310.
36. Lin C. Effect of nasal CPAP on ventilatory drive in normocapnic and hypercapnic patients with obstructive sleep apnoea syndrome. Eur. Respir. J. 7:1994;2005-2010.
37. Mahboubi S., Marsh R.R., Potsic W.P., Pasquariello P.S. The lateral neck radiograph in adenotonsillar hyperplasia. Int. J. Pediatr. Otorhinolaryngol. 10:1985;67-73.
38. Marcus C.L., Omlin K.J., Basinki D.J., Bailey S.L., Rachal A.B., Von Pechmann W.S., Keens T.G., Ward S.L. Normal polysomnographic values for children and adolescents. Am. Rev. Respir. Dis. 146 (5 Pt 1):1992;1235-1239.
39. Marcus C.L., Carroll J.L. Obstructive sleep apnea syndrome. Loughlin G.M., Eigen H. Respiratory Diseases in Children: Diagnosis and Management. 1994;475-499 Williams and Wilkins, Baltimore.
40. Marcus C.L., Carroll J.L., Koerner C.B., Hamer A., Lutz J., Loughlin G.M. Determinants of growth in children with the obstructive sleep apnea syndrome. J. Pediatr. 125:1994;556-562.
41. Marcus C.L., Glomb W.B., Basinski D.J., Davidson S.L., Keens T.G. Developmental pattern of hypercapnic and hypoxic ventilatory responses from childhood to adulthood. J. Appl. Physiol. 76:1994;314-320.
42. Marcus C.L., Gozal D., Arens R., Basinski D.J., Omlin K.J., Keens T.G., Ward S.L. Ventilatory responses during wakefulness in children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 149 (3 Pt 1):1994;715-721.
43. Marcus C.L., McColley S.A., Carroll J.L., Loughlin G.M., Smith P.L., Schwartz A.R. Upper airway collapsibility in children with obstructive sleep apnea syndrome. J. Appl. Physiol. 77:1994;918-924.
44. Marcus C.L., Greene M.G., Carroll J.L. Blood pressure in children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 157:1998;1098-1103.
45. Marcus C.L., Lutz J., Carroll J.L., Bamford O. Arousal and ventilatory responses during sleep in children with obstructive sleep apnea. J. Appl. Physiol. 84:1998;1926-1936.
46. Marcus C.L. Pathophysiology of OSAS in children. Loughlin G.M., Carroll J.L., Marcus C.L. Sleep and Breathing in Children - A Developmental Approach. 1999;Dekker, New York. (in press).
47. Marcus C.L., Bamford O., Bamford O., Lutz J. Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea. J. Appl. Physiol. 87:1999;1448-1454.
48. Marcus C.L., Lutz J., Hamer A., Smith P.L., Schwartz A. Developmental changes in response to subatmospheric pressure loading of the upper airway. J. Appl. Physiol. 87:1999;626-633.
49. McNamara F., Issa F.G., Sullivan C.E. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J. Appl. Physiol. 81:1996;2651-2657.
50. Mezzanotte W.S., Tangel D.J., White D.P. Mechanisms of control of alae nasi muscle activity. J. Appl. Physiol. 72:1992;925-933.
51. Mezzanotte W.S., Tangel D.J., White D.P. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J. Clin. Invest. 89:1992;1571-1579.
52. Mezzanotte W.S., Tangel D.J., White D.P. Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls. Am. J. Respir. Crit. Care Med. 153 (6 Pt 1):1996;1880-1887.
53. Mograss M.A., Ducharme F.M., Brouillette R.T. Movement/arousals. Description, classification, and relationship to sleep apnea in children. Am. J. Respir. Crit. Care Med. 156 (6 Pt 1):1994;1690-1696.
54. Morielli A., Ladan S., Ducharme F.M., Brouillette R.T. Can sleep and wakefulness be distinguished in children by cardiorespiratory and videotape recordings? Chest. 109:1996;680-687.
55. Osler W. Chronic Tonsillitis. Osler W. The Principles and Practice of Medicine. 1892;335-339 Appleton, New York.
56. Praud J.P., d'Allest A.M., Nedelcoux H., Curzi-Dascalova L., Guilleminault C., Gaultier C. Sleep-related abdominal muscle behavior during partial or complete obstructed breathing in prepubertal children. Pediatr. Res. 26:1989;347-350.
57. Redline S., Leitner J., Arnold J., Tishler P.V., Altose M.D. Ventilatory-control abnormalities in familial sleep apnea. Am. J. Respir. Crit. Care. Med. 156:1997;155-160.
58. Redline S., Tishler P.V., Schluchter M., Aylor J., Clark K., Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am. J. Respir. Crit. Care. Med. 159:1999;1527-1532.
59. Roffwarg H.P., Muzio J.N., Dement W.C. Ontogenetic development of the human sleep-dream cycle. Science. 152:1966;604-619.
60. 2. J. Appl. Physiol. 74:1993;1597-1605.
61. Schwartz A.R., Thut D.C., Russ B., Seelagy M., Yuan X., Brower R.G., Permutt S., Wise R.A., Smith P.L. Effect of electrical stimulation of the hypoglossal nerve on airflow mechanics in the isolated upper airway. Am. Rev. Respir. Dis. 147:1993;1144-1150.
62. Smith P.L., Wise R.A., Gold A.R., Schwartz A.R., Permutt S. Upper airway pressure-flow relationships in obstructive sleep apnea. J. Appl. Physiol. 64:1988;789-795.
63. Springer C., Wasserman K. Evidence that maturation of the peripheral chemoreceptors is not complete in childhood. Respir. Physiol. 74:1988;55-64.
64. Strohl K.P., Redline S. Nasal CPAP therapy, upper airway muscle activation, and obstructive sleep apnea. Am. Rev. Respir. Dis. 134:1986;555-558.
65. Suen J.S., Arnold J.E., Brooks L.J. Adenotonsillectomy for treatment of obstructive sleep apnea in children. Arch. Otolaryngol. Head Neck Surg. 121:1995;525-530.
66. Vaughn V.C. Growth and development. Behrman R.E., Vaughn V.C. Nelson Textbook of Pediatrics. 1983;10-38 Saunders, Philadelphia, PA.
67. Weiner D., Mitra J., Salamone J., Cherniack N.S. Effects of chemical stimuli on nerves supplying upper airway muscles. J. Appl. Physiol. 52:1982;530-536.
68. Weitzman E.D., Kahn E., Pollak C.P. Quantitative analysis of sleep and sleep apnea before and after tracheostomy in patients with the hypersomnia-sleep apnea syndrome. Sleep. 3:1980;407-423.
69. Widdicombe J.G. Reflexes from the upper respiratory tract. Cherniack N.S., Widdicombe J.G. Handbook of Physiology - The Respiratory System II. 1986;363-394 American Physiological Society, Bethesda, MD.
70. Yoshizawa T., Akashiba T., Kurashina K., Otsuka K., Horie T. Genetics and obstructive sleep apnea syndrome: a study of human leukocyte antigen (HLA) typing. Int. Med. 32(2):1993;94-97.
71. Young T., Palta M., Dempsey J., Skatrud J., Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. New Engl. J. Med. 328:1993;1230-1235.