Arousal and ventilatory responses during sleep in children with obstructive sleep apnea

Journal of Applied Physiology

Volumn 84, Issue 6, 1998, Pages 1926-1936

  Marcus, Carole L ^a,b   Lutz, Janita ^a   Carroll, John L ^a   Bamford, Owen ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Sleep disordered breathing; Ventilatory control; Ventilatory drive

Indexed keywords

AROUSAL; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MALE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RESPIRATION CONTROL; RESPIRATORY DRIVE; SCHOOL CHILD; SLEEP; SLEEP APNEA SYNDROME;

EID: 0031858905     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.84.6.1926     Document Type: Article

References (32)

1. American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am. J. Respir. Crit. Care Med. 153: 866-878, 1996.
2. Bayadi, S. E., R. P. Millman, P. V. Tishler, C. Rosenberg, W. Saliski, M. A. Boucher, and S. Redline. A family study of sleep apnea. Chest 98: 554-559, 1990.
3. Berthon-Jones, M., and C. E. Sullivan. Ventilatory and arousal responses to hypoxia in sleeping humans. Am. Rev. Respir. Dis. 125: 632-639, 1982.
4. 2 with long-term CPAP therapy for obstructive sleep apnea. Am. Rev. Respir. Dis. 135: 144-147, 1987.
5. Busby, K. A., L. Mercier, and R. T. Pivik. Ontogenetic variations in auditory arousal threshold during sleep. Psychophysiology 31: 182-188, 1994.
6. Condos, R., R. G. Norman, I. Krishnasamy, N. Peduzzi, R. M. Goldring, and D. M. Rapoport. Flow limitation as a noninvasive assessment of residual upper-airway resistance during continuous positive airway pressure therapy of obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 150: 475-480, 1994.
7. Dejours, P. Chemoreflexes in breathing. Physiol. Rev. 42: 335-358, 1962.
8. Douglas, N. J., D. P. White, J. V. Weil, C. K. Pickett, and C. W. Zwillich. Hypercapnic ventilatory response in sleeping adults. Am. Rev. Respir. Dis. 126: 758-762, 1982.
9. Frank, Y., R. E. Kravath, C. P. Pollak, and E. D. Weitzman. Obstructive sleep apnea and its therapy: clinical and polysomnographic manifestations. Pediatrics 71: 737-742, 1983.
10. Garay, S. M., D. Rapoport, B. Sorkin, H. Epstein, I. Feinberg, and R. M. Goldring. Regulation of ventilation in the obstructive sleep apnea syndrome. Am. Rev. Respir. Dis. 124: 451-457, 1981.
11. Gothe, B., M. D. Goldman, N. S. Cherniack, and P. Mantey. Effect of progressive hypoxia on breathing during sleep. Am. Rev. Respir. Dis. 126: 97-102, 1982.
12. Gozal, D., R. Arens, K. J. Omlin, J. H. Ben-Ari, G. Aljadeef, R. M. Harper, and T. G. Keens. Ventilatory response to consecutive short hypercapnic challenges in children with obstructive sleep apnea. J. Appl. Physiol. 79: 1608-1614, 1995.
13. Guilleminault, C. Obstructive sleep apnea syndrome and its treatment in children: areas of agreement and controversy. Pediatr. Pulmonol. 3: 429-436, 1987.
14. 2 after tracheostomy in obstructive sleep apnea syndrome. Am. Rev. Respir. Dis. 126: 14-20, 1982.
15. Hedemark, L. L., and R. S. Kronenberg. Ventilatory and heart rate responses to hypoxia and hypercapnia during sleep in adults. J. Appl. Physiol. 53: 307-312, 1982.
16. Hudgel, D. W., C. Hendricks, and A. Dadley. Alteration in obstructive apnea pattern induced by changes in oxygen- and carbon-dioxide-inspired concentrations. Am. Rev. Respir. Dis. 138: 16-19, 1988.
17. Laurikainen, E., M. Erkinjuntti, J. Alihanka, H. Rikalainen, and J. Suonpaa. Radiological parameters of the bony nasopharynx and the adenotonsillar size compared with sleep apnea episodes in children. Int. J. Pediatr. Otorhinolaryngol. 12: 303-310, 1987.
18. Livingston, F. R., R. Arens, S. L. Bailey, T. G. Keens, and S. L. D. Ward. Hypercapnic arousal responses in Prader-Willi syndrome. Chest 108: 1627-1631, 1995.
19. Longobardo, G. S., B. Gothe, M. D. Goldman, and N. S. Cherniack. Sleep apnea considered as a control system instability. Respir. Physiol. 50: 311-333, 1982.
20. Marcus, C. L., D. B. Bautista, A. Ammahyia, S. L. D. Ward, and T. G. Keens. Hypercapneic arousal responses in children with congenital central hypoventilation syndrome. Pediatrics 88: 993-998, 1991.
21. Marcus, C. L., D. Gozal, R. Arens, D. J. Basinski, K. J. Omlin, T. G. Keens, and S. L. D. Ward. Ventilatory responses during wakefulness in children with obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 149: 715-721, 1994.
22. Marcus, C. L., S. A. McColley, J. L. Carroll, G. M. Loughlin, P. L. Smith, and A. R. Schwartz. Upper airway collapsibility in children with obstructive sleep apnea syndrome. J. Appl. Physiol. 77: 918-924, 1994.
23. Marcus, C. L., J. L. Carroll, O. Bamford, P. Pyzik, and G. M. Loughlin. Supplemental oxygen during sleep in children with sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 152: 1297-1301, 1995.
24. Marcus, C. L., S. L. D. Ward, G. B. Mallory, C. L. Rosen, R. C. Beckerman, D. E. Weese-Mayer, R. T. Brouillette, H. T. Trang, and L. J. Brooks. Use of nasal continuous positive airway pressure as treatment for childhood obstructive sleep apnea. J. Pediatr. 127: 88-94, 1995.
25. McNamara, F., F. G. Issa, and C. E. Sullivan. Arousal pattern following central and obstructive breathing abnormalities in infants and children. J. Appl. Physiol. 81: 2651-2657, 1996.
26. Parisi, R. A., N. H. Edelman, and T. V. Santiago. Central respiratory carbon dioxide chemosensitivity does not decrease during sleep. Am. Rev. Respir. Dis. 145: 832-836, 1992.
27. Rechtschaffen, A., and A. Kales (Editors). A Manual of Standardized Terminology: Techniques and Scoring Systems for Sleep Stages of Human Subjects. Los Angeles, CA: UCLA Brain Information Service/Brain Research Institute, 1968.
28. Sleep Disorders Atlas Task Force. EEG arousals: scoring rules and examples. Sleep 15: 173-184, 1992.
29. Sullivan, C. E., R. R. Grunstein, O. Marrone, and M. Berthon-Jones. Sleep apnea-pathophysiology: upper airway and control of breathing. In: Obstructive Sleep Apnea Syndrome, edited by C. Guilleminault. New York: Raven, 1990, p. 49-71.
30. Van der Hal, A. L., A. M. Rodriguez, C. W. Sargent, A. C. G. Platzker, and T. G. Keens. Hypoxic and hypercapneic arousal responses and prediction of subsequent apnea in apnea of infancy. Pediatrics 75: 848-854, 1985.
31. Ward, S. L. D., D. B. Bautista, and T. G. Keens. Hypoxic arousal in normal infants. Pediatrics 89: 860-864, 1992.
32. Weiner, D., J. Mitra, J. Salamone, and N. S. Cherniack. Effect of chemical stimuli on nerves supplying upper airway muscles. J. Appl. Physiol. 52: 530-536, 1982.