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Volumn 21, Issue 6, 2000, Pages 1253-1257

8,9-Dihydroxy-8,9-dihydrodibenzo[a, l]pyrene is a potent morphological cell-transforming agent in C3H10T1/2C18 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE DERIVATIVE; DEOXYADENOSINE; DEOXYGUANOSINE; POLYCYCLIC AROMATIC HYDROCARBON;

EID: 0034093888     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.6.1253     Document Type: Article
Times cited : (8)

References (41)
  • 1
    • 0004002991 scopus 로고
    • Cambridge University Press, Cambridge, UK
    • Osborne, M.R. and Crosby, N.T. (1987) Benzopyrenes. Cambridge University Press, Cambridge, UK.
    • (1987) Benzopyrenes
    • Osborne, M.R.1    Crosby, N.T.2
  • 2
    • 0001917141 scopus 로고
    • Carcinogenicity and mutagenicity of proximate and ultimate carcinogens of polycyclic aromatic hydrocarbons
    • CRC Press, Boca Raton, FL
    • Wislocki, P.G. and Lu, A.Y.H. (1988) Carcinogenicity and mutagenicity of proximate and ultimate carcinogens of polycyclic aromatic hydrocarbons. In Polycyclic Aromatic Hydrocarbon Carcinogenesis: Structure-Activity Relationships. CRC Press, Boca Raton, FL, Vol. 1, pp. 1-30.
    • (1988) Polycyclic Aromatic Hydrocarbon Carcinogenesis: Structure-activity Relationships , vol.1 , pp. 1-30
    • Wislocki, P.G.1    Lu, A.Y.H.2
  • 3
    • 0032425394 scopus 로고    scopus 로고
    • Metabolic activation of racemic and enantiomeric trans-8,9-dihydroxy-8,9-dihydrodibenzo [a, l]pyrene (dibenzo[def, p]chrysene) to dibenzo[a, l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: The role of the K-region-derived metabolic intermediates in the formation of dibenzo[a, l]pyrene-DNA adducts
    • Nesnow, S., Davis, C., Padgett, W., George, M. Lambert, G., Meyers, F., Allison, J., Adams, L. and King, L.C. (1998) Metabolic activation of racemic and enantiomeric trans-8,9-dihydroxy-8,9-dihydrodibenzo [a, l]pyrene (dibenzo[def, p]chrysene) to dibenzo[a, l]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[a, l]pyrene-DNA adducts. Chem. Res. Toxiicol., 11, 1596-1607.
    • (1998) Chem. Res. Toxiicol. , vol.11 , pp. 1596-1607
    • Nesnow, S.1    Davis, C.2    Padgett, W.3    George, M.4    Lambert, G.5    Meyers, F.6    Allison, J.7    Adams, L.8    King, L.C.9
  • 4
    • 0029588582 scopus 로고
    • Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke
    • Mumford, J.L., Li, X., Hu, F., Lu, X.B. and Chuang, J.C. (1995) Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke. Carcinogenesis, 16, 3031-3036.
    • (1995) Carcinogenesis , vol.16 , pp. 3031-3036
    • Mumford, J.L.1    Li, X.2    Hu, F.3    Lu, X.B.4    Chuang, J.C.5
  • 5
    • 0026002897 scopus 로고
    • Comparative dose-response tumorigenicity studies of dibenzo[a, l]pyrene versus 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and two dibenzo[a, l]pyrene dihydrodiols in mouse skin and rat mammary gland
    • Cavalieri, E.L., Higginbotham, S., RamaKrishna, N.V., Devanesan, P.D., Todorovic, R., Rogan, E.G. and Salmasi, S. (1991) Comparative dose-response tumorigenicity studies of dibenzo[a, l]pyrene versus 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene and two dibenzo[a, l]pyrene dihydrodiols in mouse skin and rat mammary gland. Carcinogenesis, 12, 1939-1944.
    • (1991) Carcinogenesis , vol.12 , pp. 1939-1944
    • Cavalieri, E.L.1    Higginbotham, S.2    RamaKrishna, N.V.3    Devanesan, P.D.4    Todorovic, R.5    Rogan, E.G.6    Salmasi, S.7
  • 6
    • 0031408862 scopus 로고    scopus 로고
    • Dibenzo[a, l]pyrene-induced DNA adduction, tumorigenicity and Ki-ras oncogene mutations in strain A/J mouse lung
    • Prahalad, A.K., Ross, J.A., Nelson, G.B., Roop, B.C., King, L.C., Nesnow, S. and Mass, M.J. (1997) Dibenzo[a, l]pyrene-induced DNA adduction, tumorigenicity and Ki-ras oncogene mutations in strain A/J mouse lung. Carcinogenesis, 18, 1955-1963.
    • (1997) Carcinogenesis , vol.18 , pp. 1955-1963
    • Prahalad, A.K.1    Ross, J.A.2    Nelson, G.B.3    Roop, B.C.4    King, L.C.5    Nesnow, S.6    Mass, M.J.7
  • 7
    • 0031416521 scopus 로고    scopus 로고
    • Comparison of the morphological transforming activities of dibenzo[a, l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a, l]pyrene-DNA adducts
    • Nesnow, S., Davis, C., Nelson, G., Ross, J.A., Allison, J., Adams, L. and King, L.C. (1997) Comparison of the morphological transforming activities of dibenzo[a, l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a, l]pyrene-DNA adducts. Carcinogenesis, 18, 1973-1978.
    • (1997) Carcinogenesis , vol.18 , pp. 1973-1978
    • Nesnow, S.1    Davis, C.2    Nelson, G.3    Ross, J.A.4    Allison, J.5    Adams, L.6    King, L.C.7
  • 8
    • 0028785807 scopus 로고
    • Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites
    • Chakravarti, D., Pelling, J.C., Cavalieri, E.L. and Rogan, E.C. (1995) Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites. Proc. Natl Acad. Sci. USA, 92, 10422-10426.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10422-10426
    • Chakravarti, D.1    Pelling, J.C.2    Cavalieri, E.L.3    Rogan, E.C.4
  • 9
    • 0015752438 scopus 로고
    • Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division
    • Reznikoff, C.A., Brankow, D.W. and Heidelberger, C. (1973) Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res., 33, 3231-3238.
    • (1973) Cancer Res. , vol.33 , pp. 3231-3238
    • Reznikoff, C.A.1    Brankow, D.W.2    Heidelberger, C.3
  • 10
    • 0027346285 scopus 로고
    • 32P-postlabelling analysis of bulky aromatic adducts
    • Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds). IARC Scientific Publications no. 124, IARC, Lyon
    • 32P-Postlabelling analysis of bulky aromatic adducts. In Phillips, D.H., Castegnaro, M. and Bartsch, H. (eds) Postlabelling Methods for Detection of DNA Adducts. IARC Scientific Publications no. 124, IARC, Lyon, pp. 11-23.
    • (1993) Postlabelling Methods for Detection of DNA Adducts , pp. 11-23
    • Gupta, R.C.1
  • 11
    • 0020334611 scopus 로고
    • 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts
    • 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis, 3, 1081-1092.
    • (1982) Carcinogenesis , vol.3 , pp. 1081-1092
    • Gupta, R.C.1    Reddy, M.V.2    Randerath, K.3
  • 12
    • 0022774562 scopus 로고
    • 32P-postlabeling test for structurally diverse DNA adducts
    • 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis, 7, 1543-1551.
    • (1986) Carcinogenesis , vol.7 , pp. 1543-1551
    • Reddy, M.V.1    Randerath, K.2
  • 13
    • 0028168138 scopus 로고
    • 32P-postlabeled DNA adducts of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons by HPLC
    • 32P-postlabeled DNA adducts of polycyclic aromatic hydrocarbons and nitrated polycyclic aromatic hydrocarbons by HPLC. Chem. Res. Toxicol., 7, 503-510.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 503-510
    • King, L.C.1    George, M.2    Gallagher, J.E.3    Lewtas, J.4
  • 14
    • 0024363808 scopus 로고
    • 32P-labeled phosphates of major polynuclear aromatic hydrocarbon-deoxyribonucleoside adducts
    • 32P-labeled phosphates of major polynuclear aromatic hydrocarbon-deoxyribonucleoside adducts. Carcinogenesis, 10, 1971-1974.
    • (1989) Carcinogenesis , vol.10 , pp. 1971-1974
    • Amin, S.1    Misra, B.2    Desai, D.3    Huie, K.4    Hecht, S.S.5
  • 15
    • 0032881284 scopus 로고    scopus 로고
    • A quantitative comparison of dibenzo[a, l]pyrene-DNA adduct formation by recombinant human cytochrome p450 microsomes
    • King, L.C., Adams, L., Allison, J., Kohan, M.J., Nelson, G., Desai, D., Amin, S. and Ross, J.A. (1999) A quantitative comparison of dibenzo[a, l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes. Mol. Carcinog., 26, 74-82.
    • (1999) Mol. Carcinog. , vol.26 , pp. 74-82
    • King, L.C.1    Adams, L.2    Allison, J.3    Kohan, M.J.4    Nelson, G.5    Desai, D.6    Amin, S.7    Ross, J.A.8
  • 16
    • 0032871769 scopus 로고    scopus 로고
    • Structure elucidation of the adducts formed by fjord-region dibenzo[a, l]pyrene 11,12-dihydrodiol 13,14-epoxides and deoxyadenosine
    • Li, K.M., George, M., Gross, M.L., Seidel, A., Luch, A., Rogan, E.G. and Cavalieri, E.L. (1999) Structure elucidation of the adducts formed by fjord-region dibenzo[a, l]pyrene 11,12-dihydrodiol 13,14-epoxides and deoxyadenosine. Chem. Res. Toxicol., 12, 758-767.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 758-767
    • Li, K.M.1    George, M.2    Gross, M.L.3    Seidel, A.4    Luch, A.5    Rogan, E.G.6    Cavalieri, E.L.7
  • 18
    • 0027093718 scopus 로고
    • The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation
    • Cavalieri, E.L. and Rogan, E.G. (1992) The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation. Pharmacol. Ther., 55, 183-199.
    • (1992) Pharmacol. Ther. , vol.55 , pp. 183-199
    • Cavalieri, E.L.1    Rogan, E.G.2
  • 19
    • 0027953509 scopus 로고
    • Bisdihydrodiols, rather than dihydrodiol oxides, are the principal microsomal metabolites of tumorigenic trans-3,4-dihydroxy-3,4-dihydrodibenz[a, h]anthracene
    • Platt, K.L. and Schollmeier, M. (1994) Bisdihydrodiols, rather than dihydrodiol oxides, are the principal microsomal metabolites of tumorigenic trans-3,4-dihydroxy-3,4-dihydrodibenz[a, h]anthracene. Chem. Res. Toxicol., 7, 89-97.
    • (1994) Chem. Res. Toxicol. , vol.7 , pp. 89-97
    • Platt, K.L.1    Schollmeier, M.2
  • 20
    • 0027532252 scopus 로고
    • Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a, h]anthracene to DNA-binding species in mouse skin
    • Carmichael, P.L., Platt, K.L., She, M.N., Lecoq, S., Oesch, F., Phillips, D.H. and Grover, P.L. (1993) Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a, h]anthracene to DNA-binding species in mouse skin. Cancer Res., 53, 944-948.
    • (1993) Cancer Res. , vol.53 , pp. 944-948
    • Carmichael, P.L.1    Platt, K.L.2    She, M.N.3    Lecoq, S.4    Oesch, F.5    Phillips, D.H.6    Grover, P.L.7
  • 21
    • 0032838774 scopus 로고    scopus 로고
    • Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase
    • Shimada, T., Gillam, E.M., Oda, Y., Tsumura, F., Sutter, T.R., Guengerich, F.P. and Inoue, K. (1999) Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase. Chem. Res. Toxicol., 12, 623-629.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 623-629
    • Shimada, T.1    Gillam, E.M.2    Oda, Y.3    Tsumura, F.4    Sutter, T.R.5    Guengerich, F.P.6    Inoue, K.7
  • 23
    • 0032937593 scopus 로고    scopus 로고
    • Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: Generation of reactive and redox active o-quinones
    • Penning, T.M., Burczynski, M.E., Hung, C.F., McCoull, K.D., Palackal, N.T. and Tsuruda, L.S. (1999) Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chem. Res. Toxicol., 12, 1-18.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 1-18
    • Penning, T.M.1    Burczynski, M.E.2    Hung, C.F.3    McCoull, K.D.4    Palackal, N.T.5    Tsuruda, L.S.6
  • 24
    • 0033535436 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbons: Correlations between DNA adducts and ras oncogene mutations
    • Ross, J.A. and Nesnow, S. (1999) Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations. Mutat. Res., 424, 155-166.
    • (1999) Mutat. Res. , vol.424 , pp. 155-166
    • Ross, J.A.1    Nesnow, S.2
  • 25
    • 0023202567 scopus 로고
    • Morphological transforming activity and metabolism of cyclopema-fused isomers of benz[a]anthracene in mammalian cells
    • Mohapatra, N., MacNair, P., Bryant, B.J., Ellis, S., Rudo, K., Sangaiah, R., Gold, A. and Nesnow, S. (1987) Morphological transforming activity and metabolism of cyclopema-fused isomers of benz[a]anthracene in mammalian cells. Mutat. Res., 188, 323-334.
    • (1987) Mutat. Res. , vol.188 , pp. 323-334
    • Mohapatra, N.1    MacNair, P.2    Bryant, B.J.3    Ellis, S.4    Rudo, K.5    Sangaiah, R.6    Gold, A.7    Nesnow, S.8
  • 26
    • 0022993608 scopus 로고
    • Quantitative analysis of the metabolism of benzo(a)pyrene by transformable C3H10T1/2CL8 mouse embryo fibroblasts
    • Rudo, K., Ellis, S., Bryant, B.J., Lawrence, K., Curtis, G., Garland, H. and Nesnow, S. (1986) Quantitative analysis of the metabolism of benzo(a)pyrene by transformable C3H10T1/2CL8 mouse embryo fibroblasts, Teratog. Carcinog. Mutagen., 6, 307-319.
    • (1986) Teratog. Carcinog. Mutagen. , vol.6 , pp. 307-319
    • Rudo, K.1    Ellis, S.2    Bryant, B.J.3    Lawrence, K.4    Curtis, G.5    Garland, H.6    Nesnow, S.7
  • 27
    • 0031573465 scopus 로고    scopus 로고
    • Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia colt exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1BI
    • Savas, U., Carstens, C.P. and Jefcoate, C.R. (1997) Biological oxidations and P450 reactions. Recombinant mouse CYP1B1 expressed in Escherichia colt exhibits selective binding by polycyclic hydrocarbons and metabolism which parallels C3H10T1/2 cell microsomes, but differs from human recombinant CYP1BI. Arch. Biochem. Biophys., 347, 181-192.
    • (1997) Arch. Biochem. Biophys. , vol.347 , pp. 181-192
    • Savas, U.1    Carstens, C.P.2    Jefcoate, C.R.3
  • 28
    • 0027988255 scopus 로고
    • Morphological transformation and DNA adduct formation by dibenz[a, h]anthracene and its metabolites in C3H10T1/2CL8 cells
    • Nesnow, S., Ross, J., Beck, S., Lasley, J., Nelson, G., Lambert, G., Platt, K.L. and Agarwal, S.C. (1994) Morphological transformation and DNA adduct formation by dibenz[a, h]anthracene and its metabolites in C3H10T1/2CL8 cells. Carcinogenesis, 15, 2225-2231.
    • (1994) Carcinogenesis , vol.15 , pp. 2225-2231
    • Nesnow, S.1    Ross, J.2    Beck, S.3    Lasley, J.4    Nelson, G.5    Lambert, G.6    Platt, K.L.7    Agarwal, S.C.8
  • 29
    • 0026319329 scopus 로고
    • Morphological transformation and DNA adduct formation by benz[j]aceanthrylene and its metabolites in C3H10T1/2CL8 cells: Evidence for both cyclopenta-ring and bay-region metabolic activation pathways
    • Nesnow, S., Lasley, J., Curti, S., Ross, J., Nelson, G., Sangaiah, R. and Gold, A. (1991) Morphological transformation and DNA adduct formation by benz[j]aceanthrylene and its metabolites in C3H10T1/2CL8 cells: evidence for both cyclopenta-ring and bay-region metabolic activation pathways. Cancer Res., 51, 6163-6169.
    • (1991) Cancer Res. , vol.51 , pp. 6163-6169
    • Nesnow, S.1    Lasley, J.2    Curti, S.3    Ross, J.4    Nelson, G.5    Sangaiah, R.6    Gold, A.7
  • 31
    • 0017279935 scopus 로고
    • The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines
    • Nesnow, S. and Heidelberger, C. (1976) The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines. Cancer Res., 36, 1801-1808.
    • (1976) Cancer Res. , vol.36 , pp. 1801-1808
    • Nesnow, S.1    Heidelberger, C.2
  • 32
    • 0028111994 scopus 로고
    • cDNA cloning, sequence analysis and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1
    • Shen, Z., Liu, J., Wells, R.L. and Elkind, M.M. (1994) cDNA cloning, sequence analysis and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1. DNA Cell Biol., 13, 763-769.
    • (1994) DNA Cell Biol. , vol.13 , pp. 763-769
    • Shen, Z.1    Liu, J.2    Wells, R.L.3    Elkind, M.M.4
  • 33
    • 0032804346 scopus 로고    scopus 로고
    • Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity
    • Alexander, D.L., Zhang, L., Foroozesh, M. Alworth, W.L. and Jefcoate, C.R. (1999) Metabolism-based polycyclic aromatic acetylene inhibition of CYP1B1 in 10T1/2 cells potentiates aryl hydrocarbon receptor activity. Toxicol. Appl. Pharmacol., 161, 123-139.
    • (1999) Toxicol. Appl. Pharmacol. , vol.161 , pp. 123-139
    • Alexander, D.L.1    Zhang, L.2    Foroozesh, M.3    Alworth, W.L.4    Jefcoate, C.R.5
  • 34
    • 0032961838 scopus 로고    scopus 로고
    • Metabolic activation of dibenzo[a, l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells
    • Luch, A., Schober, W., Soballa, V.J., Raab, G., Greim, H., Jacob, J., Doehmer, J. and Seidel, A. (1999) Metabolic activation of dibenzo[a, l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells. Chem. Res. Toxicol., 12, 353-364.
    • (1999) Chem. Res. Toxicol. , vol.12 , pp. 353-364
    • Luch, A.1    Schober, W.2    Soballa, V.J.3    Raab, G.4    Greim, H.5    Jacob, J.6    Doehmer, J.7    Seidel, A.8
  • 35
    • 0033567882 scopus 로고    scopus 로고
    • The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a, l]pyrene to DNA-binding metabolites by human cytochrome p450 1A1 or 1B1
    • Luch, A., Kishiyama, S., Seidel, A., Doehmer, J., Greim, H. and Baird, W.M. (1999) The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a, l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1. Cancer Res., 59, 4603-4609.
    • (1999) Cancer Res. , vol.59 , pp. 4603-4609
    • Luch, A.1    Kishiyama, S.2    Seidel, A.3    Doehmer, J.4    Greim, H.5    Baird, W.M.6
  • 36
    • 0032100577 scopus 로고    scopus 로고
    • Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: Role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism
    • Larsen, M.C., Angus, W.G., Brake, P.B., Eltom, S.E., Sukow, K.A. and Jefcoate, C.R. (1998) Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Cancer Res., 58, 2366-2374.
    • (1998) Cancer Res. , vol.58 , pp. 2366-2374
    • Larsen, M.C.1    Angus, W.G.2    Brake, P.B.3    Eltom, S.E.4    Sukow, K.A.5    Jefcoate, C.R.6
  • 37
    • 0011156743 scopus 로고
    • Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 C1 8 mouse fibroblasts
    • Landolph, J.R. and Heidelberger, C. (1979) Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 C1 8 mouse fibroblasts. Proc. Natl Acad. Sci. USA, 76, 930-934.
    • (1979) Proc. Natl Acad. Sci. USA , vol.76 , pp. 930-934
    • Landolph, J.R.1    Heidelberger, C.2
  • 38
    • 0020080058 scopus 로고
    • Induction of cytotoxicity, mutation, cytogenetic changes and neoplastic transformation by benzodo(a)pyrene and derivatives in C3H/10T1/ 2 clone 8 mouse fibroblasts
    • Gehly, E.B., Landolph, J.R., Heidelberger, C., Nagasawa, H. and Little, J.B. (1982) Induction of cytotoxicity, mutation, cytogenetic changes and neoplastic transformation by benzodo(a)pyrene and derivatives in C3H/10T1/ 2 clone 8 mouse fibroblasts. Cancer Res., 42, 1866-1875.
    • (1982) Cancer Res. , vol.42 , pp. 1866-1875
    • Gehly, E.B.1    Landolph, J.R.2    Heidelberger, C.3    Nagasawa, H.4    Little, J.B.5
  • 39
    • 0020694155 scopus 로고
    • Formation of benzo(a)pyrene/DNA adduets and their relationship to tumor initiation in mouse epidermis
    • Ashurst, S.W., Cohen, G.M., Nesnow, S., DiGiovanni, J. and Slaga, T.J. (1983) Formation of benzo(a)pyrene/DNA adduets and their relationship to tumor initiation in mouse epidermis. Cancer Res., 43, 1024-1029.
    • (1983) Cancer Res. , vol.43 , pp. 1024-1029
    • Ashurst, S.W.1    Cohen, G.M.2    Nesnow, S.3    DiGiovanni, J.4    Slaga, T.J.5
  • 40
    • 0028967218 scopus 로고
    • Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels
    • Ross, J.A., Nelson, G.B., Wilson, K.H., Rabinowitz, J.R., Galati, A., Stoner, G.D., Nesnow, S. and Mass, M.J. (1995) Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels. Cancer Res., 55, 1039-1044.
    • (1995) Cancer Res. , vol.55 , pp. 1039-1044
    • Ross, J.A.1    Nelson, G.B.2    Wilson, K.H.3    Rabinowitz, J.R.4    Galati, A.5    Stoner, G.D.6    Nesnow, S.7    Mass, M.J.8
  • 41
    • 0032543725 scopus 로고    scopus 로고
    • Detection of dibenzo[a, l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method
    • Chakravarti, D., Mailander, P., Franzen, J., Higginbotham, S., Cavalieri, E.L. and Rogan, E.G. (1998) Detection of dibenzo[a, l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method. Oncogene, 16, 3203-3210.
    • (1998) Oncogene , vol.16 , pp. 3203-3210
    • Chakravarti, D.1    Mailander, P.2    Franzen, J.3    Higginbotham, S.4    Cavalieri, E.L.5    Rogan, E.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.