The relation of plasma total homocysteine levels to prevalent cardiovascular disease in older patients with ischemic stroke

Aging Clinical and Experimental Research

Volumn 12, Issue 1, 2000, Pages 48-52

  Adunsky, A ^a   Weitzman, A ^a   Fleissig, Y ^a   Levenkrohn, L ^a   Arad, M ^a   Doolman, R ^a,b   Gavendo, S ^a,b   Sela, B A ^a,b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Elderly; Homocysteine; Myocardial infarction; Stroke

Indexed keywords

HOMOCYSTEINE;

ADULT; AGE; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENDER; GERIATRIC PATIENT; HEART INFARCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; RISK FACTOR;

EID: 0034093761     PISSN: 03949532     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03339828     Document Type: Article

References (23)

1. Brattstrom L., Lindgren A., Israelsson B., Anderson A., Hultberg B.: Homocysteine and cysteine: determinants of plasma levels in middle-aged and elderly subjects. J. Intern. Med. 236: 633-641, 1994.
2. Selhub J., Jacques P.F., Wilson P.W.F., Rush D., Rosenberg I.H.: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270: 2693-2698, 1993.
3. Welch N.G., Loscalzo J.: Homocysteine and atherothrombosis. N. Engl. J. Med. 338: 1042-1050, 1998.
4. Selhub J., D'Angelo A.: Relationship between homocysteine and thrombotic disease. Am. J. Med. Sci. 316: 129-141, 1998.
5. Freyburger G., Labrouche S., Sassoust G., Rouanet F., Javorschi S., Parrot F.: Mild hyperhomocysteinemia and hemostatic factors in patients with arterial vascular disease. Thromb. Haemost. 77: 466-471, 1976.
6. Alfthan G., Pekkanen L., Jauhiainen M., Pitkaniemi J., Karvonen M., Tuomilehto J., Salonen J.T., Ehnholm C.: Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 106: 9-19, 1994.
7. Verhoef P., Hennekens C.H., Malinow R., Kok F.J., Willet W.C., Stampfer M.J.: A prospective study of plasma homocyst(e)ine and risk of ischemic stroke. Stroke 25: 1924-1930, 1994.
8. Arnesen E., Refsum H., Bonaa K.H., Ueland P.M., Forde O.H., Nordehaug J.E.: Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24: 704-709, 1995.
9. Bots M.L., Launer L.J., Lindemans J., Hofman A., Grobbee D.E.: Homocysteine, atherosclerosis and prevalent cardiovascular disease in the elderly: the Rotterdam study. J. Intern. Med. 242: 339-347, 1997.
10. Stehouwer D.A., Weijenberg P.M., Van den Berg M., Jakobs C., Feskens J.M., Kromhout D.: Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men. A 10-year-follow up. Arterioscler. Thromb. Vasc. Biol. 18: 1895-1901, 1998.
11. Brattstrom L., Lindgren A., Israelsson B., Malinow M.R., Norrving B., Upson B., Hamfelt A.: Hyperhomocystinemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur. J. Clin. Invest. 22: 214-221, 1992.
12. Coull B.M., Malinow M.R., Beamer N., Sexton G., Nordt F., De Garmo P.: Elevated plasma homocyst(e)ine concentrations as a possible independent risk factor for stroke. Stroke 21: 572-576, 1990.
13. Adams H.P., Bendixen H.B., Kappelle L.J., Biller J., Love B.B., Gordon D.L., Marsh E.E., and the TOAST investigators: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke 24: 35-41, 1993.
14. Jacobsen D.W., Gatautis V.J., Green R., Robinson K., Savon S.R., Secic M., Ji J.I., Otto J.M., Taylor L.M.: Rapid HPLC determination of total homocysteine and other thiols in serum and plasma: sex differences and correlation with cobalamin and folate concentrations in healthy subjects. Clin. Chem. 40: 873-881, 1994.
15. BMDP Statistical Software. University of California Press, 1990.
16. Lindgren A., Brattstrom L., Norrving B., Hultberg B., Andersson A., Johansson B.B.: Plasma homocysteine in the acute and convalescent phases after stroke. Stroke 26: 795-800, 1995.
17. Hoogeveen E.K., Konstense P.J., Beks P.J., Mackaay A.J., Jakobs C., Bouter L.M., Heine R.J., Stehouwer C.D.: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non insulin dependent diabetes mellitus: a population-based study. Arterioscler. Thromb. Vasc. Biol. 18: 133-138, 1998.
18. Kark J.D., Selhub B., Adler B., Gofin J., Abramson J.H., Friedman G., Rosenberg J.H.: Non fasting total homocysteine level and mortality in middle aged and elderly men and women in Jerusalem. Ann. Intern. Med. 131: 321-329, 1999.
19. Fasbender K., Mielke O., Bertsch T., Nafe B., Froschen S., Hennerici M.: Homocysteine in cerebral macroangiopathy and microangiopathy. Lancet 353: 1586-1587, 1999.
20. Munshi M.N., Stone A., Fink L., Fonesca V.: Hyperhomocysteinemia following a methionine load in patients with non-insulin dependent diabetes mellitus and macrovascular disease. Metabolism 45: 133-135, 1996.
21. Fonesca V.A., Stone A., Munshi M., Baliga B.S., Aljada A., Thusu K., Fink L., Dondona P.: Oxidative stress in diabetic macrovascular disease: does homocysteine play a role? South. Med. J. 90: 903-906, 1997.
22. Pametti L., Bottiglieri T., Lowenthal D.: Role of homocysteine in age related vascular and non vascular diseases. Aging Clin. Exp. Res. 9: 241-257, 1997.
23. Evers S., Koch H.G., Grotemeyer K.H., Lange B., Deufel T., Ringelstein B.E.: Features, symptoms and neurophysiological findings in stroke associated with hyperhomocysteinemia. Arch. Neurol. 54: 1276-1282, 1997.