The 'adrenaline hypothesis' of hypertension revisited: Evidence for adrenaline release from the heart of patients with essential hypertension

Journal of Hypertension

Volumn 18, Issue 6, 2000, Pages 717-723

  Rumantir, Magdalena S ^a,c   Jennings, Garry L ^a   Lambert, Gavin W ^a   Kaye, David M ^a   Seals, Douglas R ^b   Esler, Murray D ^a  

^a ALFRED HOSPITAL   (Australia)

^b UNIVERSITY OF COLORADO   (United States)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Cotransmitter; Heart; Noradrenaline; Sympathetic nervous system; adrenoceptors

Indexed keywords

ADRENALIN; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENALIN RELEASE; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FEMALE; HEART; HEART CATHETERIZATION; HUMAN; MALE; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; PHARMACOKINETICS; PRIORITY JOURNAL; SYMPATHETIC NERVE; THEORY;

EID: 0034092426     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200018060-00009     Document Type: Article

References (32)

1. 1 Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans: evidence from direct intraneural recordings. Hypertension 1989; 14:177-183.
2. 2 Grassi M, Esler M. How to assess sympathetic activity in humans. J Hypertens 1999; 17:719-734.
3. 3 Wallin BG, Delius W, Hagbarth K-E. Comparison of sympathetic nerve activity in normotensive and hypertensive subjects. Circ Res 1973; 33: 9-21.
4. 4 Esler M, Jennings G, Korner P, Willett I, Dudley F, Hasking G, et al. The assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 1988; 11:3-20.
5. 5 Cassis LA, Stitzel RE, Head RJ. Hypernoradrenergic innervation of the caudal artery of the spontaneously hypertensive rat: an influence upon neuroeffector mechanisms. J Pharmacol Exp Ther 1985; 234:792-803.
6. 6 Majewski H, Rand MJ, Tung LH. Activation of prejuctional β-adrenoceptors in rat atria by adrenaline applied exogenously or released as a co-transmitter. Br J Pharmacol 1981; 73:669-679.
7. 7 Brown MJ, Macquin I. Is adrenaline the cause of essential hypertension? Lancet 1981; 2:1079-1081.
8. 8 Floras JS. Epinephrine and the genesis of hypertension. Hypertension 1992; 19:1-18.
9. 9 Esler M, Jackman G, Bobik A, Leonard P, Kelleher D, Skews H, et al. Norepinephrine kinetics in essential hypertension. Defective neuronal uptake of norepinephrine in some patients. Hypertension 1981; 3:149-156.
10. 10 Carmona MM, Soares-da-silva P. The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues. Br J Physiol 1985; 86:351-356.
11. 11 Kawai C, Yui Y, Hoshino T, Sasayama S, Matsumori A: Myocardial catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study. J Am Coll Cardiol 1983; 2:834-840.
12. 12 Stjarne L, Brundin J. Dual adrenoceptor-mediated control of noradrenaline secretion from human vasoconstrictor nerves: Facilitation by β-receptors and inhibition by α-receptor. Acta Physiol Scand 1975; 94:139-141.
13. 13 Westfall TC, Peach MJ, Tittermary V. Enhancement of electrically induced release of noradrenaline from the rat portal vein: mediation by adrenoceptors. Eur J Pharmacol 1979; 58:67-74.
14. 14 Majewski H, McCulloch MJ, Rand MJ, Story DF. Adrenaline activation of prejunctional β-adrenoreceptors in guinea pig atria. Br J Pharmacol 1980; 71:435-444.
15. 15 Esler M, Eisenhofer G, Chin J, Jennings G, Meredith I, Cox H, et al. Is adrenaline released by sympathetic nerves in man? Clin Autonom Res 1991; 1:103-108.
16. 16 Kaye DM, Lefkovits J, Cox H, Lambert G, Jennings G, Turner A, et al. Regional epinephrine kinetics in human heart failure: evidence for extra-adrenal, non-neural release. Am J Physiol 1995; 269:H182-H188.
17. 17 Wilkinson DJC, Thompson JM, Lambert GW, Jennings GL, Schwarz RG, Jeffreys D, et al. Sympathetic activity in patients with panic disorder at rest, under laboratory mental stress, and during panic attacks. Arch Gen Psychiatry 1998; 55:511-520.
18. 18 Thomson JM, Wallin BG, Lambert GW, Jennings GL, Esler MD. Human muscle sympathetic activity and cardiac catecholamine spillover: no support for augmented sympathetic noradrenaline release by adrenaline co-transmission. Clin Sci 1998; 94:383-393.
19. 19 Johansson M, Rundqvist B, Eisenhofer G, Friberg P. Cardiorenal epinephrine kinetics: evidence for release in the human heart. Am J Physiol 1997; 273:H2178-H2185.
20. 20 Esler M, Jennings G, Lambert G, Meredith I, Horne M, Eisenhofer G. Overflow of catecholamine neurotransmitters to circulation: source, fate and functions. Physiol Rev 1990; 70:963-985.
21. 21 Eisenhofer G, Esler MD, Cox HS, Meredith IT, Jennings GL, Brush Jr JE, et al. Differences in the neuronal removal of circulating epinephrine and norepinephrine J Clin Endocrinol Metab 1990; 70:1710-1720.
22. 22 Cox HS, Kaye DM, Thompson JM, Turner AG, Jennings GL, Itsiopoulos C, et al. Regional sympathetic nervous activation following a large meal in humans. Clin Sci 1995; 89:145-154.
23. 23 Medvedev OS, Esler MD, Angus JA, Cox HS, Eisenhofer G. Simultaneous determination of plasma noradrenaline and adrenaline kinetics. Response to nitroprusside-induced hypertension and 2-deoxyglucose-induced glucopenia in the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 1990; 341:192-199.
24. 24 Esler MD, Kaye D, Thompson J, Jennings G, Cox H, Turner A, et al. Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart. J Clin Endocrinol Metab 1995; 80:435-442.
25. 25 Kennedy B, Elayan H, Ziegler MG. Lung epinephrine synthesis. Am J Physiol 1992; 258;L227-L231.
26. 26 Huang M-H, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, et al. An intrinsic adrenergic system in mammalian heart. J Clin Invest 1996; 98:1298-1303.
27. 27 Vincent HH, man In't Veld AJ, Boomsma F, Wenting GJ, Schalekamp MADH. Elevated plasma noradrenaline in response to β-adrenoceptor stimulation in man. Br J Clin Pharmacol 1982; 13:717-721.
28. 28 Blankestijn PJ, Man In't Veld AJ, Tulen J, Van Den Meiracker AH, Boomsma F, Moleman P, et al. Support for adrenaline-hypertension hypothesis: 18 hour pressor effect after 6 h adrenaline infusion. Lancet 1988; 2:1386-1389.
29. 29 Floras JS, Sole MJ, Morris BL. Desipramine blocks augmented neurogenic vasocontrictror responses to epinephrine. Hypertension 1990; 15:132-139.
30. 30 Esler M. Sympathetic activity in experimental and human hypertension. In: Mancia G, Zanchetti A (editors): Handbook of hypertension, vol. 17: pathophysiology of hypertension. Amsterdam: Elsevier; 1997. pp. 628-673.
31. 31 Newton GE, Parker JD. Acute effects of beta 1-selective and nonselective beta-adrenergic blockade on cardiac sympathetic activity in congestive heart failure. Circulation 1996; 94:353-358.
32. 32 Newton GE, Azevedro ER, Parker JD. Inotropic and sympathetic responses to the intracoronary infusion of a β2-reoeptor agonist. A human in vivo study. Circulation 1999; 99:2402-2407.