Induction of apoptosis by mitomycin-C in an ex vivo model of bladder cancer

BJU International

Volumn 85, Issue 7, 2000, Pages 911-917

  Kelly, J D ^b   Williamson, K E ^a   Weir, H P ^a   McManus, D T ^a   Hamilton, P W ^a   Keane, P F ^c   Johnston, S R ^c  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Institute of Clinical Sciences B   (United Kingdom)

^c NONE

Author keywords

Apoptosis; Bladder; Chemotherapy; Culture; TCC; Tissue

Indexed keywords

MITOMYCIN C;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER STAGING; CHEMOTHERAPY; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG RESPONSE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INCUBATION TIME; OUTCOMES RESEARCH; PRIORITY JOURNAL; TRANSITIONAL CELL CARCINOMA;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARCINOMA, TRANSITIONAL CELL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MITOMYCIN; TIME FACTORS; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 0034091729     PISSN: 14644096     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410X.2000.00667.x     Document Type: Article

References (27)

1. 1 Evans DL, Tilby M, Dive C. Differential sensitivity to the induction of apoptosis by cisplatinum in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation. Cancer Res 1994; 54: 1596-603
2. 2 Dive C, Hickman JA. Drug-target interactions: only the first step in the commitment to a programmed cell death. Br J Cancer 1991; 64: 192-6
3. 3 Hamburger A, Salmon S. Primary bioassay of human tumour stem cells. Science 1977; 197: 461-5
4. 4 Koopman G, Reutelingsperger CPM, Kuijten GAM, Keechnen RMJ, Pals ST, van Oers MHJ. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415-20
5. 5 Raff MC. Social controls on cell survival and cell death. Nature 1992; 356: 397-400
6. 6 Boersma AWM, Nooter K, Burger H, Kortland CJ, Stoter G. Bax upregulation is an early event in cisplatin-induced apoptosis in human testicular germ-cell tumour cell line NT2, as quantitaled by flow cytometry. Cytometry 1997; 27: 275-82
7. 7 Thomas A, El Rouby Reed JC, Krajewski S, Silber R, Potmesil M, Newcomb EW. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene 1996; 12: 1055-62
8. 8 Stephens LC, Schultheiss TE, Small SM, Ang KK, Peters LJ. Response of parotid gland organ culture to radiation. Radiation Res 1989; 120: 140-53
9. 9 Stephens LC, Ang KK, Schultheiss TE, Milas L, Meyn RE. Apoptosis in irradiated murine tumours. Radiation Res 1991; 127: 308-16
10. 10 Schroeder FH, Cooper EH, Debruyne FMJ. TNM classification of genito-urinary tumours. Position of the EORTC Genito Urinary Group. Br J Urol 1987; 62: 501-10
11. 11 Mostofi FK, Sobin LH, Torloni H. Histological typing of urinary bladder tumours. International classification of bladder tumours, no. 10. Geneva: WHO, 1973
12. 12 Kelly JD, McManus D, Weir HP et al. Validation of a rapid method to quantify apoptosis in superficial bladder cancer. Br J Urol 1997; 80: 927-32
13. 13 van der Meijden AP, Hall RR, Macaluso MP, Pawinsky A, Sylvester R, van Glabbeke M. Marker tumour responses to the sequential combination of intravesical therapy with mitomycin-C and BCG-RIVM in multiple superficial bladder tumours. Report from the European Organisation for Research and Treatment on Cancer-Genitourinary Group (EORTC 30897). Eur Urol 1996; 29: 199-203
14. 14 Schmittgen TD, Au JL-S, Wientjes MG, Badalament RA, Drago JR. Cultured human bladder tumours for pharmacodynamic studies. J Urol 1991; 145: 203-7
15. 15 Stewart RJG, Lawson AH, Weaver JPA. The ultrastructure of transitional cell carcinomas of the human urinary bladder treated with ethoglucid or mitomycin. J Urol 1988; 139: 1355-8
16. 16 Perrapato SD, Slocum HK, Huben RP, Ghosh R, Rustum Y. Assessment of human genitourinary tumours and chemosensitivity testing in 3-dimensional collagen gel culture. J Urol 1990; 143: 1041-5
17. 17 Lawson AH, Riches AC, Weaver JPA. Human bladder tumour in organ cultures. J Urol 1986; 135: 1061-4
18. 18 Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. Cancer Res 1994; 124: 619-26
19. 19 Simon R, Burger H, Brinkschmuidt C, Bocker W, Hertle L, Terpe H. Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol 1998; 185: 345-51
20. 20 Sauter G, Mihatsch MJ. Pussycats and baby tigers: non-invasive (pTa) and minimally invasive (pTl) bladder carcinomas are not the same! J Pathol 1998; 185: 339-41
21. 21 Lipponen PK, Aaltomaa S. Apoptosis in bladder cancer as related to standard prognostic factors and prognosis. J Pathol 1994; 173: 333-9
22. 22 Chyle V, Pollack A, Czerniak B et al. Apoptosis and downstaging after preoperative radiotherapy for muscle-invasive bladder cancer. Int J Rad Oncol 1996; 35: 281-7
23. 23 Mesner PWJ, Budihardjo II, Kaufmann SH. Chemotherapy-induced apoptosis. Adv Pharmacol 1997; 41: 461-99
24. 24 van der Meijden AP, Hall RR, Kurth KH, Bouffioux C, Sylvester R. Phase II trials in Ta, Tl bladder cancer. The marker tumour concept. Br J Urol 1996; 77: 634-7
25. 25 Bouffioux C, van der Meijden AP, Kurth CH et al. Objective response criteria to intravesical therapy: the marker lesion. In Pagano F, Fair WR. eds. Superficial Bladder Cancer, 1st can. Oxford: Isis Medical Media, 1997:90-6
26. 26 Dusre T, Rajagopalan S, Eliot HM, Covey JM, Sinha BK. DNA interstrand cross-link and free radical formation in a human multidrug-resistant cell line from mitomycin C and its analogues. Cancer Res 1990; 50: 648-52
27. 27 Schmitt CA, Lowe S. Apoptosis and therapy. J Pathol 1999; 187: 127-37