Marked enhancement of anti-allodynic effect by combined intrathecal administration of the adenosine A1-receptor agonist R- phenylisopropyladenosine and morphine in a rat model of central pain

Acta Anaesthesiologica Scandinavica

Volumn 44, Issue 6, 2000, Pages 665-671

  Von Heijne, Margareta ^a   Hao, J X ^a   Sollevi, A ^a   Xu, X J ^a   Wiesenfeld Hallin, Z ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Analgesics: adenosine, morphine; Anesthetic technique: spinal; Pain: central, allodynia, neuropathic; Spinal cord: interaction, potentiation

Indexed keywords

ADENOSINE A1 RECEPTOR AGONIST; MORPHINE; PHENYLISOPROPYLADENOSINE;

ALLODYNIA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; LUMBAR SPINAL CORD; NEUROPATHY; NEUROTRANSMITTER RELEASE; NONHUMAN; PHOTOCHEMISTRY; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; STIMULUS RESPONSE;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; INJECTIONS, SPINAL; MORPHINE; PAIN; PHENYLISOPROPYLADENOSINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1;

EID: 0034089586     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2000.440606.x     Document Type: Article

References (27)

1. 1. Boivie J. Central Pain. In: Wall PD, Melzack R, eds. Textbook of Pain. Edinburgh: Churchill Livingstone, 1994: 871-900.
2. 2. Yezierski RP. Pain following spinal cord injury: the clinical problem and experimental studies. Pain 1996: 68: 185-194.
3. 3. Arnér S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988: 33: 11-23.
4. 4. Yaksh TL. Pharmacology and mechanisms of opioid analgesic activity. Acta Anaesthesiol Scand 1997: 41: 94-111.
5. 5. Fredholm BB. Adenosine receptors in the central nervous system. Physiol Sci 1995: 10: 122-128.
6. 2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study. J Pharmacol Exp Ther 1988: 247: 757-764.
7. 7. Karlsten R, Gordh T, Jr., Hartvig P, Post C. Effects of intrathecal injection of the adenosine receptor agonists R-phenylisopropyl-adenosine and N-ethylcarboxamide-adenosine on nociception and motor function in the rat. Anesth Analg 1990: 71: 60-64.
8. 8. Li J, Perl ER. Adenosine inhibition of synaptic transmission in the substantia gelatinosa. J Neurophysiology 1994: 72: 1611-1621.
9. 1 agonist blocks NMDA-evoked release of excitatory amino acids and adenosine as measured by intrathecal loop microdialysis. Abstr Soc Neurosci 1998: 24: 1629.
10. 10. Lee YW, Yaksh TL. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J Pharmacol Exp Ther 1996: 277: 1642-1648.
11. 11. Cui JG, Sollevi A, Linderoth B, Meyerson BA. Adenosine receptor activation suppresses tactile hypersensitivity and potentiates spinal cord stimulation in mononeuropathic rats. Neurosci Lett 1997: 223: 173-176.
12. 1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain. Neurosci Lett 1998: 243: 89-92.
13. 1-receptor agonist R-phenylisopropyladenosine on repeated intrathecal administration and lack of cross-tolerance with morphine in a rat model of central pain. Anesth Analg 1998: 87: 1367-1371.
14. 14. von Heijne M, Hao J-X, Sollevi A, Xu X-J. Intrathecal adenosine does not relieve allodynia-like behavior in spinally injured rats. Neuroreport 1999: 10: 3247-3251.
15. 15. Belfrage M, Sollevi A, Segerdahl M, Sjölund KF, Hansson P. Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. Anesth Analg 1995: 81: 713-717.
16. 16. Belfrage M, Segerdahl M, Arnér S, Sollevi A. Safety and efficacy of intrathecal adenosine in patients with chronic neuropathic pain. Anesth Analg 1999: 89: 136-142.
17. 17. Segerdahl M, Ekblom A, Sandelin K, Wickman M, Sollevi A. Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics. Anesth Analg 1995: 80: 1145-1149.
18. 1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. Anesth Analg 1995: 80: 844-847.
19. 19. Mantegazza P, Tammiso R, Zambotti F, Zecca L, Zonta N. Purine involvement in morphine antinociception. Br J Pharmacol 1984: 83: 883-888.
20. 20. DeLander GE, Keil GJ. Antinociception induced by intrathecal coadministration of selective adenosine receptor and selective opioid receptor in mice. J Pharmacol Exp Ther 1994: 268: 943-951.
21. 21. Reeve AJ, Dickenson AH. The roles of spinal adenosine receptors in the control of acute and more persistent nociceptive responses of dorsal horn neurones in the anaesthetized rat. Br J Pharmacol 1995: 116: 2221-2228.
22. 22. Lavand'homme PM, Eisenach JC. Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain. Pain 1999: 80: 31-36.
23. 23. Xu XJ, Hao JX, Aldskogius H, Seiger A, Wiesenfeld-Hallin Z. Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 1992: 48: 279-290.
24. 24. Hao JX, Xu XJ. Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered excitatory amino acid receptor antagonists. Pain 1996: 66: 279-285.
25. 25. Hao JX, Yu W, Xu XJ, Wiesenfeld-Hallin Z. Capsaicin-sensitive afferents mediate chronic cold, but not mechanical, allodynia-like behavior in spinally injured rats. Brain Res 1996: 722: 177-180.
26. 26. Sosnowski M, Yaksh TL. Role of spinal adenosine receptors in modulating the hyperesthesia produced by spinal glycine receptor antagonism. Anesth Analg 1989: 69: 587-592.
27. 27. Sawynok J, Sweeney MI, White TD. Adenosine release may mediate spinal analgesia by morphine. Trends Pharmacol Sci 1989: 10: 186-189.