Spontaneous monoclonal immunoglobulin-secreting peripheral blood mononuclear cells as a marker of disease severity in multiple myeloma

British Journal of Haematology

Volumn 108, Issue 3, 2000, Pages 549-558

  Cordoba, Franck ^a,b   Lavabre Bertrand, Thierry ^b   Salhi, Sharon Lynn ^c   Huguet, Marie France ^a   Gerfaux, Jacqueline ^a   Rossi, Jean Francois ^b   Vendrell, Jean Pierre ^a  

^a Centre National de la Recherche Scientifique   (France)

^b LAPEYRONIE HOSPITAL   (France)

^c UNIV MONTPELLIER   (France)

Author keywords

Circulating plasma cells; Monoclonal immunoglobulin; Multiple myeloma; Peripheral blood mononuclear cells

Indexed keywords

ALBUMIN; BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN MU CHAIN; MEMBRANE ANTIGEN; PARAPROTEIN; PLASMA PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; MALE; MONONUCLEAR CELL; MULTIPLE MYELOMA; PLASMA CELL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; WALDENSTROEM MACROGLOBULINEMIA;

ADULT; AGED; ANTIBODY-PRODUCING CELLS; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN ISOTYPES; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MULTIPLE MYELOMA; PLASMA CELLS; WALDENSTROM MACROGLOBULINEMIA;

EID: 0034088487     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01899.x     Document Type: Article

References (17)

1. Amadori, A., Zamarchi, R., Ciminale, L., Del Mistro, A., Siervo, S., Alberti, A., Colombatti, M. & Chieco-Bianchi, L. (1989) HIV-1 specific B cell activation: a major constituent of spontaneous B cell activation during HIV-1 infection. Journal of Immunology, 143, 2146-2152.
2. Bataille, R. & Harousseau, J.L. (1997) Multiple myeloma. The New England Journal of Medicine, 336, 1657-1664.
3. Bataille, R., Grenier, J. & Sany, J. (1984) Beta-2 microglobulin in myeloma, optimal use for staging, prognosis and treatment. A prospective study of 160 patients. Blood, 63, 468-472.
4. Bataille, R., Klein, B., Durie, B. & Pileri, A. (1992) C-reactive protein and b-2 microglobulin produce a simple and powerful myeloma staging system. Blood, 80, 733-737.
5. Bengzeng, J.C. & Epstein, J. (1996) Circulating clonal lymphocytes in myeloma constitute a minor subpopulation of B cells. Blood, 87, 1972-1976.
6. Billadeau, D., Quam, L., Thomas, W., Kay, N., Greipp, P.R., Kyle, R.A., Oken, M. & Van Ness, B. (1992) Detection and quantification of malignant cells in the peripheral blood of multiple myeloma patients. Blood, 80, 1818-1824.
7. Billadeau, D., Van Ness, B., Kimlinger, T., Kyle, R.A., Therneau, T.M., Greipp, P.R. & Witzig, T.E. (1996) Clonal circulating cells are common in plasma cell proliferative disorders: a comparison of monoclonal gammopathy of undetermined significance, smoldering multiple myeloma and active myeloma. Blood, 88, 289-296.
8. Conge, A.M., Tarte, K., Reynes, J., Segondy, M., Gerfaux, J., Zembala, M. & Vendrell, J.P. (1998) Impairment of B-lymphocyte differentiation induced by triggering of the B-cell antigen receptor and CD40 in advanced HIV-1 disease. Acquired Immunodeficiency Disease Syndrome, 12, 1437-1449.
9. Czerkinsky, C., Moldoveanu, Z., Mestecky, J., Nilsson, L. & Ouchterlony, O. (1988) A novel two color ELISPOT assay. Journal of Immunological Methods, 115, 31-37.
10. Dreyfus. F., Ribrag, V., Leblond, V., Ravaud, P., Melle, J., Quarre, M.C., Pillier, C., Boccacio, C. & Varet, B. (1995) Detection of malignant B cells in peripheral blood stem cell collections after chemotherapy in patients with multiple myeloma. Bone Marrow Transplantation, 15, 707-711.
11. Durie, B.G.M. & Salmon, S.S. (1985) Staging, Kinetics, and Flow Cytometry of Multiple Myeloma, Vol. 2. Neoplastic Diseases of the Blood. Churchill Livingston, New York.
12. Salmon, S.E. (1973) Immunoglobulin synthesis and tumor kinetics of multiple myeloma. Seminars in Hematology, 10, 135-147.
13. Szczepek, A.J., Seeberger, K., Wizniak, J., Mant, M.J., Belch, A.R. & Pilarski, L.M. (1998) A high frequency of circulating B cells share clonotypic Ig heavy-chain VDJ rearrangements with autologous bone marrow plasma cells in multiple myeloma, as measured by single-cell and in situ reverse transcriptase polymerase chain reaction. Blood, 92, 2844-2855.
14. Vendrell, J.P., Rabesandratana, H., Huguet, M.F., Cannat, A. & Serre, A. (1985) Brucella fractions behave as nonspecific mitogens and polyclonal B-cell activators for human lymphocytes. Infection and Immunity 50, 310-316.
15. Vendrell, J.P., Segondy, M., Ducos, J., Reynes, J., Huguet, M.F., Nicolas, J.C. & Serre, A. (1991) Analysis of the spontaneous in vitro anti-HIV-1 antibody secretion by peripheral blood mononuclear cells in HIV-1 infection. Clinical Experimental Immunology, 83, 197-202.
16. Witzig, T.E., Kimlinger, T.K., Gregory, J., Ahmann, G.J., Katzmann, J.A. & Greipp, P.R. (1996a) Detection of myeloma cells in the peripheral blood by flow cytometry. Cytometry, 26, 113-120.
17. Witzig, T.E., Gertz, M.A., Lust, J.A., Kyle, R.A., O'Fallon, W.M. & Greipp, P.R. (1996b) Peripheral blood monoclonal plasma cells as a predictor of survival in patients with multiple myeloma. Blood, 88, 1780-1787.