Serotonin reuptake inhibitor fluoxetine decreases arteriolar myogenic tone by reducing smooth muscle [Ca2+](i)

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 6, 2000, Pages 849-854

  Ungvari, Zoltan ^b   Pacher, Pal ^b   Koller, Akos ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b NONE

Author keywords

Ca2+ (i); Fluoxetine (Prozac); Fura2; L type Ca2+ channels; Nifedipine; Rat skeletal muscle arteriole

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; FLUOXETINE; FURA 2; NIFEDIPINE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; DRUG MECHANISM; EXTRACELLULAR CALCIUM; INTESTINE PRESSURE; MALE; MUSCLE CONTRACTILITY; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; RAT;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; ARTERIOLES; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; MALE; MUSCLE TONUS; MUSCLE, SKELETAL; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; RATS; RATS, WISTAR; SEROTONIN UPTAKE INHIBITORS;

EID: 0034087040     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200006000-00004     Document Type: Article

References (5)

1. Baldessarini RJ. Drugs and the treatment of psychiatric disorders. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. The pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill, 1997:431-60.
2. Colunga GJ, Awad JN, Miledi R. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac). Proc Natl Acad Sci USA 1997;94:2041-4.
3. + channels by antidepressant drugs. J Pharmacol Exp Ther 1998;284:208-14.
4. Tytgat J, Maertens C, Daenens P. Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1). Br J Pharmacol 1997;122:1417-24.
5. 3 receptor-mediated current by the selective serotonin uptake inhibitor, fluoxetine. Neurosci Lett 1994;173:210-2.