Responses in primary astrocytes and C6-Glioma cells to ammonium chloride and dibutyryl cyclic-AMP

Neurochemical Research

Volumn 25, Issue 2, 2000, Pages 277-284

  Haghighat, Nasrin ^a   McCandless, D W ^b   Geraminegad, Pedram ^b  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b NONE

Author keywords

Ammonium chloride; ATP; GFAP; Hepatic encephalopathy; Mitochondrial electron transport chain; MTT

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMMONIUM CHLORIDE; BUCLADESINE; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; GLIOMA; HEPATIC ENCEPHALOPATHY; NEUROTOXICITY; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN;

AMMONIUM CHLORIDE; ANIMALS; ASTROCYTES; BUCLADESINE; CELLS, CULTURED; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034086327     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007535922977     Document Type: Article

References (40)

1. Benjamin, A. M. and Quastel, J. H. 1972. Locations of amino acids in brain cortex slices from the rat. Tetrodotoxin- sensitive release of amino acids. Biochem. J. 128:631-646.
2. Benjamin, A. M. and Quastel, J. H. 1974. Fate of L-glutamate in the brain. J. Neurochem. 23:457-464.
3. Benjamin, A. M. and Quastel, J. H. 1975. Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: a possible role of ammonia in brain function. J. Neurochem. 25:197-206.
4. Benjamin, A. M. 1982. Ammonia, in A. Lajtha (ed.), Handbook of Neurochemistry, Vol. 1. 2nd Ed., Plenum. New York. p. 117-137.
5. Berl, S. 1971. Cerebral amino acid metabolism in hepatic coma. Exp. Biol. Med. 40:71-84.
6. Bessman, S. P. and Bessman, A. N. 1955. The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma. J. Clin. Invest. 34:622-628.
7. Bessman, S. P. 1956. Inorganic Nitrogen Metabolism, in Page 408. W. D. McElroy and B. Glass, (eds.) Baltimore: Johns Hopkins Press.
8. Butterworth, R. F. 1998 Effects of hyperamonaemia on brain function. J. Inter. Metabl. Dis. 21 (Suppl. 1):402-417.
9. Chiu, F. C. and Goldman, J. E. 1985. Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states. J. Neuroimmunol. 8:283-292.
10. Conn, H. O. and Lieberthal, M. L. 1979. The hepatic coma syndromes and lactulose, Williams and Wilkins. Baltimore.
11. Cooper, A. J. L. and Lai, J. C. K. 1987. Cerebral ammonia metabolism in normal and hyperammonemic rats. Neurochem. Pathol. 6:67-95.
12. Cooper, A. J. L. and Plum, F. 1987. Biochemistry and physiology of brain ammonia. Physiol Rev. 67:440-519.
13. Davies, D. L. and Vernadakis, A. 1986. Responses in astrocytes C6-glioma cells to ethanol and dibutyryl cyclic AMP. Deve. Brain. Res., 24:253-260.
14. DuRuisseau, J. P., Greenstein, J. P., Winitz, M., and Birnbaum, S. M. 1957. Studies on the metabolism of amino acids and related compounds in vivo. VI. Free amino acid levels in the tissues of rats protected against ammonia toxicity. Arch. Biochem. Biophys. 68:161-171.
15. Federoff, S., Neal, J., Opas, M., and Kalnins, V. I. 1984. Astrocytes cell lineage. III. The morphology of differentiating mouse astrocytes in colony culture, J. Neurocytol. 13:1-20.
16. Flannery, D. B., Hsia, E., and Wolf, B. 1982. Current status of hyperammonemic syndromes. Hepatology. 2:495-506.
17. Gregorios, J. B., Mozes, L. W., Norenberg, L. O. B., and Norenberg, M. D. 1986. Effect of cyclic AMP on ammonia-induced alteration in primary astrocytes cultures. J. Neuropathol. Exp. Neurol. 45:396-407.
18. Haghighat, N. and McCandless, D. W. 1997a. Effect of 6-aminonicotinamide on metabolism of astrocytes and C6-glioma cells. Metabolic brain disease 12(1):29-45.
19. Haghighat, N. and McCandless, D. W. 1997b. Effect of ammonium chloride on energy metabolism of astrocytes and C6-glioma cells in vitro Metabolic Brain Disease, 12(4):287-298.
20. Häussinger, D. 1983. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureagenesis in perfused rat liver. Eur. J. Biochem. 133:269-275.
21. Häussinger, D. and Gerok, W. 1983. Hepatocyte heterogeneity in glutamine uptake by isolated perfused rat liver. Eur. J. Biochem. 136:421-425.
22. Häussinger, D. and Gerok, W. 1984. New concepts in hepatic ammonia metabolism and pH regulation. In: Advances in Hepatic Encephalopathy and Urea Cycle Diseases, edited by G. Kleinberger, P. Ferenci, P. Reiderer, and H. Thaler. Basel: Karger, p. 113-125.
23. Hisa, Y. E. 1974. Inherited hyperammonemic syndromes. Gastroenterology. 67:347-374.
24. Hoyumpa, A. M., Desmond, P. V., Avant, G. R., Roberts, R. K., Schenker, S. 1979. Clinical conference. Hepatic encephalopathy. Gastroenterology. 76:84-195.
25. Huttenlocher, P. R., Schwartz, A. D., and Klatskin, G. 1969. Reye's syndrome: ammonia intoxication as a possible factor in the encephalopathy. Pediatrics. 43:443-454.
26. Keller, J. N., Pang, Z. Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., and Mattson, M. P. 1997. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta peptide: Role of the lipid peroxidation product 4-Hydroxynonenal. J. Neurochem. 69(1):273-284.
27. Lund, P., Brosnan, J. T., and Eggelston, V. 1973. The regulation of ammonia in mammalian tissues. W. Bartley, H. L., Kornberg, and J. R. Quayle. Essays in Cell Metabolism, in Pages 167-188. (eds.) New York: Wiley-Interscience.
28. Martinez, A. J. 1968. Electron microscopy in human hepatic encephalopathy. Actan Neuropathol. (Berl.). 11:82-86.
29. Mattson, M. P., Barger, S. W., Begley, J. G., and Mark, R. J. 1995. Calcium, free radicals, and excitotoxic neuronal death in primary cell culture. Methods Cell Biol. 46:187-216.
30. McKhann, G. M. and Tower, D. B. 1961. Ammonia toxicity and cerebral oxidative metabolism. Am. J. Physiol. 200:420-424.
31. Mosmann, T. 1983. Rapid calorimetric assay for cellular growth and survival. J. Immunol. Methods 65:55-63.
32. Musser, D. A. and Oseroff, A. R. 1994. The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with photofrinII. Photobiol. 59:621-626.
33. Navazio, F., Gerritsen, T., and Wright, G. J. (1961). Relationship of ammonia intoxication to convulsions and coma in rats. J. Neurochem. 8:146-151.
34. Neary, J. T., Whittemore, S. R., Zhu, G., and Norenberg, M. D. (1994) Destabilization of glial fibrillary acidic protein mRNA in astrocytes by ammonia and protection by extracellular ATP. J. Neurochem. Vol, 63. No 6. 2021-2028.
35. Norenberg, M. D., Neary, J. T., Norenberg, L. B., and McCarthy, M. (1990). Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes. J. Neuropath and Exp Neurol. Vol, 49. No 4. 399-405.
36. Roberts, E. (1980). Epilepsy and antiepileptic drugs: a speculative synthesis. In G. H. Glaser, J. K. Penry and D. M. Woodbury (eds), Antiepileptic, Drugs. Mechanism of Action. Raven, New York. p. 667-713.
37. Schousboe, A., Svennely G., and Hertz, L. (1977). Uptake and metabolism of glutamine in astrocytes cultured from dissociated mouse brain hemispheres. J. Neurochem. 29:999-1005.
38. Seigel, S. 1956. Nonparametric statistics for the behavioral sciences. McGraw-Hill Book Company, Inc.
39. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., et al. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85.
40. Summerskill, W. H. J. and Wolpert, E. (1970). Ammonia metabolism in the gut. Am. J. Clin. Nutr. 23:633-639.