Effect of short- and long-acting inhaled β2-agonists on exhaled nitric oxide in asthmatic patients

European Respiratory Journal

Volumn 10, Issue 7, 1997, Pages 1483-1488

  Yates, D H ^a,b   Kharitonov, S A ^a   Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Department of Geriatric Medicine   (Australia)

Author keywords

2 agonists; Airway inflammation; Nitric oxide; Salbutamol; Salmeterol

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; GLUCOCORTICOID; NITRIC OXIDE; SALBUTAMOL; SALMETEROL;

ADULT; AIRWAY DYNAMICS; ARTICLE; ASTHMA; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIAGNOSTIC VALUE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEROID THERAPY;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; ADULT; AEROSOLS; ALBUTEROL; ASTHMA; BREATH TESTS; BRONCHODILATOR AGENTS; BUDESONIDE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; MALE; NITRIC OXIDE; PREGNENEDIONES; TIME FACTORS;

EID: 0030859910     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.97.10071483     Document Type: Article

References (29)

1. Barnes PJ, Belvisi MG. Nitric oxide and lung disease. Thorax 1993; 48: 1034-1043.
2. Kharitonov SA, Yates D, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Endogenous nitric oxide is increased in the exhaled air of asthmatic patients. Lancet 1994; 343: 133-135.
3. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993, 6: 1268-1270.
4. Borland C, Cox Y, Higenbottam T. Measurement of exhaled nitric oxide in man. Thorax 1993; 48: 1160-1162.
5. Robbins RA, Floreani AA, Von Essen SG, et al. Measurement of exhaled nitric oxide by three different techniques. Am J Respir Crit Care Med 1996; 153: 1631-1635.
6. Kharitonov SA, Wells AU, O'Connor BJ, Hansell D, Cole PJ, Barnes PJ. Elevated levels of exhaled nitric oxide in bronchiectasis. Am J Respir Crit Care Med 1995; 151: 1889-1893.
7. Zapol WM, Rimar S, Gillis N, Marietta M, Bosken CH. Nitric oxide and the lung. Am J Respir Crit Care Med 1994; 149: 1375-1380.
8. Barnes PJ. New drugs for asthma. Eur Respir J 1993; 5: 1126-1136.
9. Robbins RA, Barnes PJ, Springall DR, et al. Expression of inducible nitric oxide synthase in human bronchial epithelial cells. Biochem Biophys Res Commun 1994; 203: 209-218.
10. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510-1513.
11. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151: 1894-1899.
12. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen J. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995; 152: 800-803.
13. Yates DH, Kharitonov SA, Robbins RA, Thomas PS, Barnes PJ. Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide. Am J Respir Crit Care Med 1995; 152: 892-896.
14. Kharitonov SA, Yates DH, Barnes PJ. Regular inhaled budesonide decreases nitric oxide concentration in the exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996; 153: 454-457.
15. Church MK, Hiroi J. Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by antiallergic drugs and salbutamol. Br J Pharmacol 1987; 90: 421-129.
16. 2-agonists in asthma. N Engl J Med 1992; 327: 1204-1208.
17. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma. J Allergy Clin Immunol 1992; 90: 32-42.
18. Barnes PJ. Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med 1995; 152: 838-860.
19. Fahy JV, Boushey HA. Controversies involving inhaled β-agonists and inhaled corticosteroids in the treatment of asthma. Clin Chest Med 1995; 16: 715-733.
20. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136: 225-231.
21. Kharitonov SA, Chung KF, Evans D, O'Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med 1996; 153: 1773-1780.
22. Di Rosa M, Radomski M, Carnuccio R, Moncaca S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 1990; 87: 10043-10049.
23. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994; 343: 518-519.
24. Kobzik L, Bredt DS, Lowenstein CJ, et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993; 9: 371-377.
25. Yates DH, Kharitonov SA, Worsdell M, Thomas PS, Barnes PJ. Exhaled nitric oxide is decreased after inhalation of a specific inhibitor of inducible nitric oxide synthase in asthmatic but not in normal subjects. Am J Respir Crit Care Med 1996; 154: 247-250.
26. Roe S, Hathaway T, Demoncheaux E, Higenbottam T, Lowry R. Exhaled nitric oxide: effects of capsaicin in healthy humans and salbutamol in asthmatics (Abstract). Thorax 1994; 49: 1051P.
27. Peters MJ, Adcock IM. Brown CR, Barnes PJ. β-adrenoceptor agonists interfere with glucorticoid receptor D NA-binding in rat lung. Eur J Pharmacol 1995; 289: 275-281.
28. Cockroft DW, Swystun V, Bhagat R. Interaction of inhaled β-agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine. Am J Respir Crit Care Med 1995; 152: 1485-1489.
29. Sears MR, Taylor DR, Print CG, et al. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 1990; 336: 1391-1396.