A positive-feedback model for the loss of acetylcholine in Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 899, Issue , 2000, Pages 283-291

  Ehrenstein, Gerald ^a   Galdzicki, Zygmunt ^b   Lange, G David ^a  

^a National Institute of Neurological Disorders   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; NEUROTRANSMITTER;

ALZHEIMER DISEASE; APOPTOSIS; CHOLINERGIC SYSTEM; CONFERENCE PAPER; EPIDEMIOLOGY; HUMAN; POSITIVE FEEDBACK;

EID: 0034082373     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06194.x     Document Type: Conference Paper

References (30)

1. 1. LOO, D.T., A. COPANI, C.J. PIKE, E.R. WHITTEMORE, A.J. WALENCEWICZ & C.W. COTMAN. 1993. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. USA 90: 7951-7955.
2. 2. HYMAN, B.T. & R.D. TERRY. 1994. Apolipoprotein E, A beta, and Alzheimer disease. J. Neuropathol. Exp. Neurol. 53: 427-428.
3. 3. YAAR, M., S. ZHAI, P.F. PILCH, S.M. DOYLE, P.B. EISENHAUER, R.E. FINE & B.A. GILCHREST. 1997. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease. J. Clin. Invest. 100: 2333-2340.
4. 4. GALDZICKI, Z., R. FUKUYAMA, K.C. WADHWANI, S.I. RAPOPORT & G. EHRENSTEIN. 1994. beta-Amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease. Brain Res. 646: 332-336.
5. 5. ALLEN, D.D., Z. GALDZICKI, S.K. BRINING, R. FUKUYAMA, S.I. RAPOPORT & Q.R. SMITH. 1997. Beta-amyloid induced increase in choline flux across PCI2 cell membranes. Neurosci. Lett. 234: 71-73.
6. 6. DAVIS, K.L., J.Y.-K. HSIEH, M.I. LEVY, T.B. HORVATH, B.M. DAVIS & R.C. MOHS. 1982. Cerebrospinal fluid acetylcholine, choline, and senile dementia of the Alzheimer's type. Psychopharmacol. Bull. 18: 193-195.
7. 7. TOHGI, H., T. ABE, K. HASHIGUCHI, M. SAHEKI & S. TAKAHASHI. 1994. Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia. Neurosci. Lett. 177: 139-142.
8. 8. EHRENSTEIN, G., Z. GALDZICKI & G.D. LANGE. 1997. The choline-leakage hypothesis for the loss of acetylcholine in Alzheimer's disease. Biophys. J. 73: 1276-1280.
9. 9. RABIZADEH, S., C.M. BITLER, L.L. BUTCHER & D.E. BREDESEN. 1994. Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity. Proc. Natl. Acad. Sci. USA 91: 3060-3063.
10. 10. BOWEN, D.M. & A.N. DAVISON. 1986. Biochemical studies of nerve cells and energy metabolism in Alzheimer's disease. Br. Med. Bull. 42: 75-80.
11. 11. HEFTI, F., J. HARTIKKA, A. SALVATIERRA, W.J. WEINER & D.C. MASH. 1986. Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain. Neurosci. Lett. 69: 1-7.
12. 12. GOEDERT, M., A. FINE, D. DAWBARN, G.K. WILCOCK & M.V. CHAO. 1989. Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Mol. Brain Res. 5: 1-7.
13. 13. PENG, Z.C., S. CHEN, G. BERTINI, H.H. SCHMIDT & M. BENTIVOGLIO. 1994. Co-localization of nitric oxide synthase and NGF receptor in neurons in the medial septal and diagonal band nuclei of the rat. Neurosci. Lett. 166: 153-156.
14. 14. GERSCHMAN, R., D.L. GILBERT, S.W. NYE & W.O. FENN. 1954. Oxygen poisoning and x-irradiation: a mechanism in common. Science 119: 623-626.
15. 15. ESTEVEZ, A.G., N. SPEAR, S.M. MANUEL, R. RADI, C.E. HENDERSON, L. BARBEITO & J.S. BECKMAN. 1998. Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J Neurosci 18: 923-931.
16. 16. KITAMURA, Y., T. OTA, Y. MATSUOKA, I. TOOYAMA, H. KIMURA, S. SHIMOHAMA, Y. NOMURA, H.P. GEBICKE & T. TANIGUCHI. 1999. Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells. Glia 25: 154-164.
17. 17. HOCKENBERY, D.M., Z.N. OLTVAI, X.M. YIN, C.L. MlLLIMAN & S.J. KORSMEYER. 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
18. 18. WALLACE, W., S.T. AHLERS, J. GOTLIB, V. BRAGIN, J. SUGAR, R. GLUCK, P.A. SHEA, K.L. DAVIS & V. HAROUTUNIAN. 1993. Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation. Proc. Natl. Acad. Sci. USA 90: 8712-8716.
19. 19. HUNG, A.Y., C. HAASS, R.M. NITSCH, W.Q. QIU, M. CITRON, R.J. WURTMAN, J.H. GROWDON & D.J. SELKOE. 1993. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J. Biol. Chem. 268: 22959-22962.
20. 20. BUXBAUM, J.D., A.A. RUEFLI, C.A. PARKER, A.M. CYPESS & P. GREENGARD. 1994. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl. Acad. Sci. USA 91: 4489-4493.
21. 21. RUMBLE, B., R. RETALLACK, C. HILBICH, G. SIMMS, G. MULTHAUP, R. MARTINS, A. HOCKEY, P. MONTGOMERY, K. BEYREUTHER & C.L. MASTERS. 1989. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease [see comments]. N. Engl. J. Med. 320: 1446-1452.
22. 22. WISNIEWSKI, K.E., H.M. WISNIEWSKI & G.Y. WEN. 1985. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 17: 278-282.
23. 23. MANN, D.M. 1988. The pathological association between Down syndrome and Alzheimer disease. Mech. Ageing Dev. 43: 99-136.
24. 24. LAI, F. & R.S. WILLIAMS. 1989. A prospective study of Alzheimer disease in Down syndrome. Arch. Neurol. 46: 849-853.
25. 25. BARTUS, R.T., R.L. DEAN, III, B. BEER & A.S. LIPPA. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-414.
26. 26. WINBLAD, B., E. MESSAMORE, C. O'NEILL & R. COWBURN. 1993. Biochemical pathology and treatment strategies in Alzheimer's disease: emphasis on the cholinergic system. Acta Neurol. Scand. Suppl. 149: 4-6.
27. 27. WOOLF, N.J., E. GOULD & L.L. BUTCHER. 1989. Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon. Neuroscience 30: 143-152.
28. 28. WOOLF, N.J., R.W. JACOBS & L.L. BUTCHER. 1989. The pontomesencephalotegmental cholinergic system does not degenerate in Alzheimer's disease. Neurosci. Lett. 96: 277-282.
29. 29. BUCK, C.R., H.J. MARTINEZ, I.B. BLACK & M.V. CHAO. 1987. Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain. Proc. Natl. Acad. Sci. USA 84: 3060-3063.
30. 30. BUCK, C.R., H.J. MARTINEZ, M.V. CHAO & I.B. BLACK. 1988. Differential expression of the nerve growth factor receptor gene in multiple brain areas. Dev. Brain Res. 44: 259-268.