Using the metabolism of PAHs in a human cell line to characterize environmental samples

Environmental Toxicology and Pharmacology

Volumn 8, Issue 2, 2000, Pages 119-126

  Jones, Jennifer M ^a   Anderson, Jack W ^a   Tukey, Robert H ^b  

^a 1185 Park Center Drive Suite a ^*  (United States)

^b San Diego   (United States)

Author keywords

Ah receptor; Chlorinated hydrocarbons; Co occurrence; CYP1A1; PAHs

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; DIOXIN; ELLIPTICINE; ETHOXYRESORUFIN DEETHYLASE; FURAN DERIVATIVE; POLYCHLORINATED BIPHENYL; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ARTICLE; CONTAMINATION; ENVIRONMENT; PRIORITY JOURNAL; REPORTER GENE; SOIL; TOXICOKINETICS; XENOBIOTIC METABOLISM;

EID: 0034080586     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1382-6689(00)00033-8     Document Type: Article

References (22)

1. Anderson J.W., Rossi S.S., Tukey R.H. et al. A biomarker, P450RGS, for assessing the potential toxicity of organic compounds in environmental samples. Environ. Toxicol. Chem. 14:1995;1159.
2. Anderson J.W., Jones J.M., Hameedi J. et al. Comparative analysis of sediment extracts from NOAA's bioeffects studies by the biomarker, P450 RGS. Mar. Environ. Res. 48:1999;407.
3. APHA, P450 reporter gene response to dioxin-like organics. Method 8070, Standard Methods for the Examination of Water and Wastewater, 19th ed., Supplement, American Public Health Association, Washington, DC, 1996, p. 24.
4. ASTM, E 1853M-96 Standard Guide for measuring the presence of planar organic compounds which induce CYP1A, using reporter gene test systems, Biological Effects and Environmental Fate; Biotechnology; Pesticides, 1997 Annual Book of ASTM Standards, vol. 11.05-Water and Environmental Technology, American Society for Testing and Materials, West Conshohocken, PA, 1999, p. 1400.
5. Bronstein I. Chemiluminescent and bioluminescent reporter gene assays. Anal. Biochem. 219:1994;169.
6. Celander M., Bremer J., Hahn M.E. et al. Glucocorticoid-xenobiotic interactions: dexamethasone-mediated potentiation of cytochrome P4501A induction by (β-naphthoflavone in a fish hepatoma cell line (PLHC-1). Environ. Toxicol. Chem. 16:1997;900.
7. Chen Y., Tukey R.H. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J. Biol. Chem. 271:1996;26261.
8. Hahn M.E., Stegeman J.J. Regulation of cytochrome P4501A1 in teleosts: sustained induction of CYP1A1 mRNA, protein, and catalytic activity by 2,3,7,8-tetrachlorodibenzofuran in the marine fish Stenotomus chrysops. Toxicol. Appl. Pharmacol. 127:1994;187.
9. Jones J.M., Anderson J.W. Cost-effective site characterization using P450 reporter gene system (RGS). Wickramanayake G.B., Hinchee R.E. Risk, Resource, and Regulatory Issues. 1998;1 Battelle, Columbus, OH.
10. Jones J.M., Anderson J.W. Relative potencies of PAHs and PCBs based on the response of human cells. Environ. Toxicol. Pharmacol. 7:1999;19.
11. Kim G.B., Anderson J.W., Bothner K. et al. Application of P450RGS (reporter gene system) as a bioindicator of sediment PAH contamination in the vicinity of Incheon Harbor, Korea. Biomarkers. 2:1997;181.
12. Kloepper-Sams P., Stegeman J.J. The temporal relationship between P450E protein content, catalytic activity, and mRNA levels in the teleost Fundulus heteroclitus following treatment with β-naphthoflavone. Arch. Biochem. Biophys. 268:1989;525.
13. Lesca P., Rafidinarivo E., Lecointe P. et al. A class of strong inhibitors of microsomal monooxygenases: the ellipticines. Chem. Biol. Interactions. 24:1979;189.
14. Pesonen M., Goksoyr A., Andersson T. Expressions of P4501A1 in a primary culture of rainbow trout hepatocytes exposed to (β-naphthoflavone or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 292:1992;228.
15. Pongratz I., Mason G., Poellinger L. Dual roles of the 90 kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. J. Biol. Chem. 267:1992;13728.
16. Postlind H., Vu T., Tukey R.H. et al. Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 118:1993;255.
17. Stegeman J.J., Brouwer M., DiGiulio R.T. et al. Molecular responses to environmental contamination: enzyme and protein systems as indicators of chemical exposure and effect. Huggett R.J., Kimerle R.A., Mehrle P.M., Bergman H.L. Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. 1992;235 Lewis, Boca Rotan, FL.
18. Stegeman J.J., Hahn M.E., Weisbrod R. et al. Induction of cytochrome P4501A1 by aryl hydrocarbon receptor agonists in porcine aorta endothelial cells in culture and cytochrome P4501A1 activity in intact cells. Mol. Pharmacol. 47:1995;296.
19. Thomson J.F., Hayes L.S., Lloyd D.B. Modulation of firefly luciferase stability and impact of studies of gene regulation. Gene. 103:1991;171.
20. US Army Corps of Engineers, Integrated Feasibility Report for Channel Improvements and Environmental Impact Statement; Columbia and Lower Willamette River Federal Navigation Channel, Final Report of the US ACOE, Portland District, August, 1999.
21. Van den Berg M. et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environmental Health Perspectives. 106:1998;775.
22. Whitlock J.P. Jr Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol. 30:1990;251.