Preparation of CM-chitin microspheres by complexation with iron(III) in w/o emulsion and their biodisposition characteristics in mice

Biomaterials

Volumn 21, Issue 17, 2000, Pages 1779-1788

  Hata, Harumi ^a   Onishi, Hiraku ^a   MacHida, Yoshiharu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Biodisposition; CM chitin microsphere; Complexation; Iron(III) chloride; w o emulsion

Indexed keywords

COMPLEXATION; EMULSIONS; IRON COMPOUNDS; METHANOL; POLYETHYLENE GLYCOLS; POLYSACCHARIDES; SCANNING ELECTRON MICROSCOPY;

BIODISPOSITION; CARBOXYMETHYLCHITIN; MICROSPHERES;

BIOMATERIALS;

CHITIN; FERRIC ION; FLUORESCEIN ISOTHIOCYANATE; MICROSPHERE; WATER OIL CREAM;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; BODY DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DISPOSITION; DRUG ELIMINATION; LUNG CLEARANCE; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; URINARY EXCRETION;

ANIMALS; CARBOHYDRATE SEQUENCE; CHITIN; DRUG CARRIERS; IRON; MALE; MICE; MOLECULAR SEQUENCE DATA; TISSUE DISTRIBUTION;

EID: 0034080120     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(00)00069-7     Document Type: Article

References (26)

1. Kishimoto S., Tamaki K. Immunohistochemical and histochemical observations in the process of burn wound healing guinea pig skin under chitin membrane dressing. Acta Dermatol-Kyoto. 82:1987;471-479.
2. Ouchi T., Banba T., Matsumoto T., Suzuki S., Suzuki M. Antitumor activity of chitosan and chitin immobilized 5-fluorouracils through hexamethylene spacers via carbamoy bonds. J Bioact Compat Polym. 4:1989;362-371.
3. Ouchi T., Banba T., Fujimoto M., Hamamoto S. Synthesis and antitumor activity of chitosan carrying 5-fluorouracils. Makromol Chem. 190:1989;1817-1825.
4. 4-(4-carboxybutyryl)-1-β-D-arabinofuranosylcytosine and chitosan as a macromolecular prodrug of 1-β-D-arabinofuranosylcytosine. Drug Des Delivery. 10:1993;343-353.
5. Yoshino T., Machida Y., Onishi H., Nagai T. Characteristics of drug loading, drug release and degradation of chitosan microspheres prepared using the dry-in-oil method. STP Pharm Sci. 6:1996;122-128.
6. Amano K., Ito E. The action of lysozyme on partially deacetylated chitin. Eur J Biochem. 85:1978;97-104.
7. Pangburn S.H., Trescony P.V., Heller J. Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. Biomaterials. 3:1982;105-108.
8. Yomota C., Komuro T., Kimura T. Studies on the degradation of chitosan films by lysozyme and release of loaded chemicals. Yakugaku Zasshi. 110:1990;442-448.
9. Nakamura F., Onishi H., Machida Y., Nagai T. Lysozyme-catalyzed degradation properties of the conjugates between chitosans having some deacetylation degrees and methotrexate. Yakuzaigaku. 52:1992;59-67.
10. Watanabe K., Saiki I., Uraki I., Tokura S., Azuma I. 6-O-Carboxymethyl-chitin (CM-chitin) as a drug carrier. Chem Pharm Bull. 38:1990;506-509.
11. Watanabe K., Saiki I., Matsumoto Y., Azuma I., Seo H., Okuyama H., Uraki Y., Miura Y., Tokura S. Antimetastatic activity of neocarzinostatin incorporated into controlled release gels of CM-chitin. Carbohydr Polym. 17:1992;29-37.
12. Song Y., Onishi H., Nagai T. Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carboxymethyl-chitin. Chem Pharm Bull. 40:1992;2822-2825.
13. Song Y., Onishi H., Nagai T. Pharmacokinetic characteristics and antitumor activity of the N-succinyl-chitosan-mitomycin C conjugate and the carboxymethyl-chitin-mitomycin C conjugate. Biol Pharm Bull. 16:1993;48-54.
14. Song Y., Onishi H., Nagai T. Conjugate of mitomycin C with N-succinyl-chitosan. In vitro release properties, toxicity and antitumor activity Int J Pharmaceut. 98:1993;121-130.
15. Song Y., Onishi H., Nagai T. Toxicity and antitumor activity of the conjugate of mitomycin C with carboxymethyl-chitin. Yakuzaigaku. 53:1993;141-147.
16. Song Y., Onishi H., Machida Y., Nagai T. Particle characteristics of carboxymethyl-chitin-mitomycin C conjugate and N-succinyl-chitosan-mitomycin C conjugate and their distribution and histological effect on some tissues after intravenous administration. STP Pharm Sci. 5:1995;162-170.
17. Mi F-L., Chen C-T., Tseng Y-C., Kuan C-Y., Shyu S-S. Iron(III)-carboxymethylchitin microsphere for the pH-sensitive release of 6-mercaptopurine. J Control Rel. 44:1997;19-32.
18. Lee K.Y., Ha W.S., Park W.H. Blood compatibility and biodegradability of partially N-acetylated chitosan derivatives. Biomaterials. 16:1995;1211-1216.
19. Carreno-Gomez B., Duncan R. Evaluation of the biological properties of soluble chitosan and chitosan microspheres. Int J Pharmaceut. 148:1997;231-240.
20. Yasutomi Y., Nakakita N., Shioya N., Kuroyanagi Y. Developmet of bio-synthetic wound dressing with drug delivery capability composed of polyurethane membrane and biological spongy material. clinical evaluation Nessho. 19:1993;102-116.
21. Nishimura S., Nishi N., Tokura S. Bioactive chitin derivatives. Activation of mouse-peritoneal macrophages by O-(carboxymethyl)chitins. Carbohyr Res. 146:1986;251-258.
22. Hata H., Onishi H., Machida Y. Evaluation of carboxymethylchitin as a drug carrier. Effect of the deacetylation degree on the biodegradation and biodisposition characteristics in mice STP Pharma Sci. 9:1999;115-121.
23. Kamiyama K., Onishi H., Machida Y. Biodisposition characteristics of N-succinyl-chitosan and 6-O-glycol-chitosan in normal and tumor-bearing mice. Biol Pharm Bull. 22:1999;179-186.
24. Sugibayashi K., Morimoto Y., Nadai T., Kato Y., Hasegawa A., Arita T. Drug-carrier property of albumin microspheres in chemotherapy. II. Preparation and tissue distribution in mice of microsphere-entrapped 5-fluorouracil. Chem Pharm Bull. 27:1979;204-209.
25. 141Ce-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs. J Pharm Sci. 69:1980;755-762.
26. Yoshioka T., Hashida M., Muranishi S., Sezaki H. Specific delivery of mitomycin C to the liver, spleen and lung. Nano- and microspherical carriers of gelatin Int J Pharmaceut. 31:1981;131-141.