Characteristics of drug loading, drug release and degradation of chitosan microspheres prepared using the dry-in-oil method

S.T.P. Pharma Sciences

Volumn 6, Issue 2, 1996, Pages 122-128

  Yoshino, T ^a   Machida, Y ^a   Onishi, H ^a   Nagai, T ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Chitosan microspheres; Degradation properties; Drug content; Drug release; Dry in oil method

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; CHITOSAN; FLUOROURACIL; MICROSPHERE; SILICONE OIL;

ARTICLE; DRUG DEGRADATION; DRUG FORMULATION; DRUG RELEASE;

EID: 0029885759     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. KAWAGUCHI T., HIROE E. and YONEZAWA N. - Development and application of water-soluble chitin and chitosan. - In : Bessatsu Food Chemical, I. Chitin/Chitosan No Kagaku, K. Ochiai Ed., Food Chemical Newspaper Inc., Tokyo, 1987, pp. 28-32.
2. AMANO K. and ITO E. - The action of lysozyme on partially deacetylated chitin. - Eur. J. Biochem., 85, 97-104, 1978.
3. PANGBURN S.H , TRESCONY P. V. and HELLER J. - Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. - Biomaterials, 3, 105-108, 1982.
4. YOMOTA C., KOMURO T. and KIMURA T. - Studies on the degradation of chitosan films by lysozyme and release of loaded chemicals. - Yakugaku Zasshi, 110, 442-448, 1990.
5. NAKAMURA F., ONISHI H., MACHIDA Y. and NAGAI T. -Lysozyme-catalyzed degradation properties of the conjugates between chitosans having some deacetylation degrees and methotrexate. - Yakuzaigaku, 52, 59-67, 1992.
6. SANNANT. - Properties of chitin and chitosan in relation to their pharmaceutical application. - Abstract for the 13th Conference on Pharmaceutical Technology, The Academy of Pharmaceutical Science and Technology, 1988, pp. 104-109.
7. YABUKI, M. (Ed.) - Chitin Chitosan No Ouyoh. - Gihodo Press, Tokyo, 1990, pp. 99-122.
8. LI Y.P., MACHIDA Y., SANNAN T. and NAGAI T. - Preparation of chitosan microspheres containing fluorouracil using the «dry-in-oil» method and its release characteristics - STP Pharma Sci., 1, 363-368, 1991.
9. KAKEMI K., SEZAKI H., MURANISHI S. and MATUI H. -Absorption and excretion of drugs. XXIX. Effect of surface-active agents on rectal absorption of sulfisoxazole from oily base. - Chem. Pharm. Bull., 15, 172-178, 1967.
10. MURANISHI S. - Efficacy and practical use of suppositories. -Yakkyoku, 18, 16-74, 1967.