Escalating dose study of a novel non-su agent, A-4166, in type 2 diabetes

Nihon University Journal of Medicine

Volumn 42, Issue 1, 2000, Pages 31-45

  Takiguchi, Kunihiko ^b   Ishihara, Hisamitsu ^b   Ohashi, Yasuo ^b   Kosaka, Kinori ^b   Hayashi, Youichi ^b   Arakawa, Yasuyuki ^b   Kikuchi, Masatoshi ^a  

^a INSTITUTE FOR ADULT DISEASES   (Japan)

^b NONE

Author keywords

D phenylalanine derivative; Initial insulin release; Oral hypoglycemic agent; Pharmacokinetics; Postprandial hyperglycemia

Indexed keywords

GLUCOSE; INSULIN; NATEGLINIDE; PLACEBO;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DOSE RESPONSE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTPRANDIAL STATE;

EID: 0034079582     PISSN: 05460352     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Shinkai, H., Toi, K., Kumashiro, I., Seto, Y., Fukuma, M., Dan, K. and Toyoshima, S.: N-Acylphenylalanines and related compounds: A new class of oral hypoglycemic agents. J. Med. Chem. 31 2092-2097 (1988)
2. 2+ in pancreatic β-cells under metabolic inhibition. Br. J. Pharmacol. 120 1191-1198 (1997)
3. Sato, Y., Nishikawa, M., Shinkai, H. and Sukegawa, E.: Possibility of ideal blood glucose control by a new oral hypoglycemic agent. N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals. Diab. Res. Clin. Pract. 12 53-60 (1991)
4. DeFronzo, R.A. and Simonson, C.D.: Oral sulfonylurea agents suppress hepatic glucose production in non-insulin dependent diabetic individuals. Diabetes Care 1 (Suppl. 1) 72-80 (1984)
5. Longnecker, P.M., Elsenhans, D.V., Leiman, M.S., Owen, E.O. and Boden, G.: Insulin and a sulfonylurea agent in non-insulin-dependent diabetes mellitus. Arch. Intern. Med. 146 673-676 (1986)
6. Groop, L.C., Barzilai, N., Ratheiser, K., Luzi, L., Wahlin-Boll, E., Melander, A. and DeFronzo. R.A.: Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans. Diabetes Care 14 724-727 (1991)
7. Kosaka, K., Hagura, R. and Kuzuya, T.: Insulin responses in equivocal and definite diabetes, with special reference to subjects who had mild glucose intolerance but later developed definite diabetes. Diabetes 26 944-952 (1977)
8. Mitrakou, A., Kelley, D., Mokan, M., Veneman, T., Pangburn, T., Reilly, J. and Gerich, J.: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N. Engl. J. Med. 326 22-29 (1992)
9. Calles-Escandon, J. and Robbins, D.C.: Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes 36 1167-1172 (1987)
10. Bruce, D.G., Chisholm, D.J., Storlien, L.H. and Kraegen, E.W.: Physiological importance of deficiency in early prandial insulin secretion in non-insulin dependent diabetes. Diabetes 37 736-744 (1988)
11. Luzi, L. and DeFronzo, R.A.: Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am. J. Physiol. 257 E241-E246 (1989)
12. Prato, D.S., Kreutzenberg, D.V., Riccio, A. and Tiengo, A.: Hepatic sensitivity to insulin: Effects of sulfonylurea drugs. Amer. J. Med. 90 6A-29S-36S (1991)
13. Ajinomoto Co.: Investigators' brochure (1995)
14. Marchetti, P. and Navalesi, R.: Pharmacokinetic-pharmacodynamic relationships of oral hypoglycemic agents: An update, Clin. Pharmacokinetic. 16 100-128 (1989)
15. Sartor, G., Mealander, A., Schersten, B. and Wahilin-Boll, E.: Serurn glibenclamide in diabetic patients, and influence of food on the kinetics and effects of glibenclamide. Diabetologia 18 17-22 (1980)
16. Ikenoue, T., Okazaki. K., Fujitani, S., Tsuchiya, Y., Akiyoshi, M., Maki, T. and Kondo, N.: Effect of a new hypoglycemic agent, A-4166 [(-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: Comparison with voglibose and glibenclamide. Biol. Pharm. Bull. 20 354-359 (1997)