Thermodynamically distinct high and low affinity states of the A1 adenosine receptor induced by G protein coupling and guanine nucleotide ligation states of G proteins

British Journal of Pharmacology

Volumn 130, Issue 3, 2000, Pages 595-604

  Lorenzen, Anna ^a   Guerra, Laura ^b   Campi, Franca ^b   Lang, Heidrun ^a   Schwabe, Ulrich ^a   Borea, Pier Andrea ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

Affinity; Binding thermodynamics; Intrinsic activity; Partial agonist; Radioligand binding

Indexed keywords

2 ANILINOADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; CLADRIBINE; ETAZOLATE; GUANINE NUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; N ETHYLMALEIMIDE; THEOPHYLLINE; XANTHINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENTHALPY; ENTROPY; LIGATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; THERMODYNAMICS;

EID: 0034077316     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703339     Document Type: Article

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