메뉴 건너뛰기




Volumn 223, Issue 3, 2000, Pages 288-294

Effects of oral administration of tamoxifen, toremifene, dehydroepiandrosterone, and vorozole on uterine histomorphology in the rat

Author keywords

[No Author keywords available]

Indexed keywords

PRASTERONE; TAMOXIFEN; TAMOXIFEN CITRATE; TOREMIFENE; VOROZOLE;

EID: 0034076817     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22341.x     Document Type: Article
Times cited : (25)

References (50)
  • 7
    • 0027200359 scopus 로고
    • Differential sensitivity of rat uterine growth and epithelium hypertrophy to estrogens and antiestrogens
    • Branham WS, Zehr DR, Sheehan DM. Differential sensitivity of rat uterine growth and epithelium hypertrophy to estrogens and antiestrogens. Proc Soc Exp Biol Med 203:297-303, 1993.
    • (1993) Proc Soc Exp Biol Med , vol.203 , pp. 297-303
    • Branham, W.S.1    Zehr, D.R.2    Sheehan, D.M.3
  • 8
    • 0028793801 scopus 로고
    • Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients
    • Tomas E, Kauppila A, Blanco G, Apaja-Sarkkinen M, Laatikainen T. Comparison between the effects of tamoxifen and toremifene on the uterus in postmenopausal breast cancer patients. Gynecol Oncol 59:261-266, 1995.
    • (1995) Gynecol Oncol , vol.59 , pp. 261-266
    • Tomas, E.1    Kauppila, A.2    Blanco, G.3    Apaja-Sarkkinen, M.4    Laatikainen, T.5
  • 9
    • 0030896699 scopus 로고    scopus 로고
    • Effects of toremifene on neonatal rat uterine growth and differentiation
    • Medlock KL, Branham WS, Sheehan DM. Effects of toremifene on neonatal rat uterine growth and differentiation. Biol Reprod 56:1239-1244, 1997.
    • (1997) Biol Reprod , vol.56 , pp. 1239-1244
    • Medlock, K.L.1    Branham, W.S.2    Sheehan, D.M.3
  • 10
    • 0029451160 scopus 로고
    • Alternate antiestrogens and approaches to the prevention of breast cancer
    • Jordan VC. Alternate antiestrogens and approaches to the prevention of breast cancer. J Cell Biochem 22(Suppl):51-57, 1995.
    • (1995) J Cell Biochem , vol.22 , Issue.SUPPL. , pp. 51-57
    • Jordan, V.C.1
  • 12
    • 0029554030 scopus 로고
    • Metabolism of dehydroepiandrosterone
    • Longcope C. Metabolism of dehydroepiandrosterone. Ann N Y Acad Sci 774:143-1482, 1995.
    • (1995) Ann N Y Acad Sci , vol.774 , pp. 143-1482
    • Longcope, C.1
  • 13
    • 0031816232 scopus 로고    scopus 로고
    • The actions of exogenous dehydroepiandrosterone in experimental animals and humans
    • Svec F, Porter JR. The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proc Soc Exp Biol Med 218:174-191, 1998.
    • (1998) Proc Soc Exp Biol Med , vol.218 , pp. 174-191
    • Svec, F.1    Porter, J.R.2
  • 14
    • 0018757962 scopus 로고
    • Inhibition of spontaneous breast cancer formation in female C3H (A vy/a) mice by long-term treatment with dehydroepiandrosterone
    • Schwartz AG. Inhibition of spontaneous breast cancer formation in female C3H (A vy/a) mice by long-term treatment with dehydroepiandrosterone. Cancer Res 39:1129-1132, 1979.
    • (1979) Cancer Res , vol.39 , pp. 1129-1132
    • Schwartz, A.G.1
  • 15
    • 0344137078 scopus 로고
    • Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats
    • Inano H, Ishii-Ohba H, Suzuki K, Yamanouchi H, Onoda M, Wakabayashi K. Chemoprevention by dietary dehydroepiandrosterone against promotion/progression phase of radiation-induced mammary tumorigenesis in rats. J Steroid Biochem Mol Biol 11:193-202, 1995.
    • (1995) J Steroid Biochem Mol Biol , vol.11 , pp. 193-202
    • Inano, H.1    Ishii-Ohba, H.2    Suzuki, K.3    Yamanouchi, H.4    Onoda, M.5    Wakabayashi, K.6
  • 17
    • 0032031874 scopus 로고    scopus 로고
    • Modulation of methylnitrosourea-induced breast cancer in Sprague-Dawley rats by dehydroepiandrosterone: Dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations
    • Lubet RA, Gordon GB, Prough RA, Lei XD, You M, Wang Y, Grubbs CJ, Steele VE, Kelloff GJ, Thomas CF, Moon RD. Modulation of methylnitrosourea-induced breast cancer in Sprague-Dawley rats by dehydroepiandrosterone: Dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res 58:921-926, 1998.
    • (1998) Cancer Res , vol.58 , pp. 921-926
    • Lubet, R.A.1    Gordon, G.B.2    Prough, R.A.3    Lei, X.D.4    You, M.5    Wang, Y.6    Grubbs, C.J.7    Steele, V.E.8    Kelloff, G.J.9    Thomas, C.F.10    Moon, R.D.11
  • 18
    • 0014467050 scopus 로고
    • Estrogenic effects of dehydroepiandrosterone and its sulfate in rats
    • Harper MJK. Estrogenic effects of dehydroepiandrosterone and its sulfate in rats. Endocrinology 84:229-235, 1969.
    • (1969) Endocrinology , vol.84 , pp. 229-235
    • Harper, M.J.K.1
  • 19
    • 0015094005 scopus 로고
    • The effect of corticotrophin on the rat uterine weight response to human chorionic gonadotrophin
    • Copenh
    • Hipkin LJ. The effect of corticotrophin on the rat uterine weight response to human chorionic gonadotrophin. Acta Endocrinol (Copenh) 67:463-469, 1971.
    • (1971) Acta Endocrinol , vol.67 , pp. 463-469
    • Hipkin, L.J.1
  • 20
    • 0015954201 scopus 로고
    • Augmentation of the rat uterine weight response to human chorionic gonadotrophin by various steroids
    • Copenh
    • Hipkin LJ. Augmentation of the rat uterine weight response to human chorionic gonadotrophin by various steroids. Acta Endocrinol (Copenh) 75:141-147, 1974.
    • (1974) Acta Endocrinol , vol.75 , pp. 141-147
    • Hipkin, L.J.1
  • 21
    • 0032146528 scopus 로고    scopus 로고
    • Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat
    • Sourla A, Flamand M, Belanger A, Labrie F. Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat. J Steroid Biochem Mol Biol 66:137-149, 1998.
    • (1998) J Steroid Biochem Mol Biol , vol.66 , pp. 137-149
    • Sourla, A.1    Flamand, M.2    Belanger, A.3    Labrie, F.4
  • 24
    • 0028594068 scopus 로고
    • Chemopreventive effects of the aromatase inhibitor vorozole (R83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats
    • Lubet RA, Steele VE, Casebolt TL, Eto I, Kelloff GJ, Grubbs CJ. Chemopreventive effects of the aromatase inhibitor vorozole (R83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats. Carcinogenesis 15:2775-2780, 1994.
    • (1994) Carcinogenesis , vol.15 , pp. 2775-2780
    • Lubet, R.A.1    Steele, V.E.2    Casebolt, T.L.3    Eto, I.4    Kelloff, G.J.5    Grubbs, C.J.6
  • 25
    • 0026518230 scopus 로고
    • Antitumoral and endocrine effects of (+) vorozole in rats bearing dimethylbenzanthracene-induced mammary tumors
    • DeCoster R, VanGinckel R, Callens M, Goeminne N, Janssens B. Antitumoral and endocrine effects of (+) vorozole in rats bearing dimethylbenzanthracene-induced mammary tumors. Cancer Res 52:1240-1244, 1992.
    • (1992) Cancer Res , vol.52 , pp. 1240-1244
    • DeCoster, R.1    Vanginckel, R.2    Callens, M.3    Goeminne, N.4    Janssens, B.5
  • 27
    • 0344948529 scopus 로고
    • Vorozole-racemate (R76713): A specific nonsteroidal aromatase inhibitor pilot study in advanced post-menopausal breast cancer
    • Borms M, Vandebroek J, Rutten J, Tytgat J, DeCoster R, Langenaeken C, Bruynseels J. Vorozole-racemate (R76713): A specific nonsteroidal aromatase inhibitor pilot study in advanced post-menopausal breast cancer. Eur J Cancer 6(Suppl):S84, 1993.
    • (1993) Eur J Cancer , vol.6 , Issue.SUPPL.
    • Borms, M.1    Vandebroek, J.2    Rutten, J.3    Tytgat, J.4    Decoster, R.5    Langenaeken, C.6    Bruynseels, J.7
  • 28
    • 0028077626 scopus 로고
    • Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer
    • Johnston SRD, Smith IE, Doody D, Jacobs S, Robertshaw H, Dowsett M. Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer. Cancer Res 54:5875-5881, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5875-5881
    • Srd, J.1    Smith, I.E.2    Doody, D.3    Jacobs, S.4    Robertshaw, H.5    Dowsett, M.6
  • 29
    • 0030926354 scopus 로고    scopus 로고
    • Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole
    • De Jong PC, Ven Jvd Nortier HWR, Maitimu-Smeele I, Donker TH, Thijssen JHH, Slee PHTJ, Blankenstein RA. Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole. Cancer Res 57:2109-2111, 1997.
    • (1997) Cancer Res , vol.57 , pp. 2109-2111
    • De Jong, P.C.1    Hwr, V.J.N.2    Maitimu-Smeele, I.3    Donker, T.H.4    Jhh, T.5    Phtj, S.6    Blankenstein, R.A.7
  • 30
  • 31
    • 0142121931 scopus 로고    scopus 로고
    • Chemopreventive efficacy of 9 cis retinoic acid (9CRA) administered singly or concurrently with torefimene, or vorozole, in the MNU-induced rat mammary tumor model
    • Lubet RA, Steele VE, Kelloff GJ, Eto I, Grubbs CJ. Chemopreventive efficacy of 9 cis retinoic acid (9CRA) administered singly or concurrently with torefimene, or vorozole, in the MNU-induced rat mammary tumor model. (abstract) Proc Am Assoc Cancer Res 39:197, 1998.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 197
    • Lubet, R.A.1    Steele, V.E.2    Kelloff, G.J.3    Eto, I.4    Grubbs, C.J.5
  • 32
    • 0030038898 scopus 로고    scopus 로고
    • Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium
    • Nephew KP, Polek TC, Khan SA. Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium. Endocrinology 137:219-224, 1996.
    • (1996) Endocrinology , vol.137 , pp. 219-224
    • Nephew, K.P.1    Polek, T.C.2    Khan, S.A.3
  • 33
    • 0014053604 scopus 로고
    • A new derivative of triphenylethylene: Effect on implantation and mode of action in rats
    • Harper MJK, Walpole AL. A new derivative of triphenylethylene: Effect on implantation and mode of action in rats. J Reprod Fertil 13:101-119, 1967.
    • (1967) J Reprod Fertil , vol.13 , pp. 101-119
    • Harper, M.J.K.1    Walpole, A.L.2
  • 34
    • 0018104230 scopus 로고
    • Prolonged oestrogenic and mitogenic activity of tamoxifen in the ovariectomized mouse
    • Martin L, Middleton E. Prolonged oestrogenic and mitogenic activity of tamoxifen in the ovariectomized mouse. J Endocrinol 78:125-129, 1978.
    • (1978) J Endocrinol , vol.78 , pp. 125-129
    • Martin, L.1    Middleton, E.2
  • 35
    • 0018909714 scopus 로고
    • Comparison of effects of estertrol and tamoxifen with those of estriol and estradiol on the immature rat uterus
    • Holinka CF, Bressler RS, Zehr DR, Gurpide E. Comparison of effects of estertrol and tamoxifen with those of estriol and estradiol on the immature rat uterus. Biol Reprod 22:913-926, 1980.
    • (1980) Biol Reprod , vol.22 , pp. 913-926
    • Holinka, C.F.1    Bressler, R.S.2    Zehr, D.R.3    Gurpide, E.4
  • 36
    • 0027980415 scopus 로고
    • Estrogenic effects of the antiprogestin onapristone (ZK98.299) in the rodent uterus
    • Bigsby RM, Young CM. Estrogenic effects of the antiprogestin onapristone (ZK98.299) in the rodent uterus. Am J Obstet Gynecol 171:188-194, 1994.
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 188-194
    • Bigsby, R.M.1    Young, C.M.2
  • 38
    • 0027201501 scopus 로고
    • Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
    • Greaves P, Goonetilleke R, Nunn G, Topham J, Orton T. Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res 53:3919-3924, 1993.
    • (1993) Cancer Res , vol.53 , pp. 3919-3924
    • Greaves, P.1    Goonetilleke, R.2    Nunn, G.3    Topham, J.4    Orton, T.5
  • 39
    • 0028925249 scopus 로고
    • PCNA-immunoreactivity in the uterus of rats after treatment with the antiestrogen tamoxifen
    • Rumpel E, Michna H, Kuhnel W. PCNA-immunoreactivity in the uterus of rats after treatment with the antiestrogen tamoxifen. Anat Anz 177:133-138, 1995.
    • (1995) Anat Anz , vol.177 , pp. 133-138
    • Rumpel, E.1    Michna, H.2    Kuhnel, W.3
  • 41
    • 0018565240 scopus 로고
    • Hormonal control of apoptosis in hamster uterine luminal epithelium
    • Sandow BA, West NB, Norman RL, Brenner RM. Hormonal control of apoptosis in hamster uterine luminal epithelium. Am J Anat 156:15-36, 1979.
    • (1979) Am J Anat , vol.156 , pp. 15-36
    • Sandow, B.A.1    West, N.B.2    Norman, R.L.3    Brenner, R.M.4
  • 42
    • 0023176701 scopus 로고
    • Hormonal regulation of cell death in rabbit uterine epithelium
    • Nawaz S, Lynch MP, Galand P, Gerschenson LE. Hormonal regulation of cell death in rabbit uterine epithelium. Am J Pathol 127:51-59, 1987.
    • (1987) Am J Pathol , vol.127 , pp. 51-59
    • Nawaz, S.1    Lynch, M.P.2    Galand, P.3    Gerschenson, L.E.4
  • 43
    • 0023612863 scopus 로고
    • Estrogens and cell death in murine luminal epithelium
    • Pollard J, Pacey J, Cheng SVY, Jordan EG. Estrogens and cell death in murine luminal epithelium. Cell Tissue Res 249:533-540, 1987.
    • (1987) Cell Tissue Res , vol.249 , pp. 533-540
    • Pollard, J.1    Pacey, J.2    Svy, C.3    Jordan, E.G.4
  • 44
    • 0024521864 scopus 로고
    • Biochemical evidence for programmed cell death in rabbit uterine epithelium
    • Rotello RJ, Hocker MB, Gerschenson LE. Biochemical evidence for programmed cell death in rabbit uterine epithelium. Am J Pathol 134:491-495, 1989.
    • (1989) Am J Pathol , vol.134 , pp. 491-495
    • Rotello, R.J.1    Hocker, M.B.2    Gerschenson, L.E.3
  • 45
    • 0017518663 scopus 로고
    • Relative binding affinity of androstane and C-19-nor-androstane-steroids for the estradiol-receptor in human myometrial and mammary cancer tissue
    • Poortman J, Vroegindewey-Jie D, Thijssen JH, Schwarz F. Relative binding affinity of androstane and C-19-nor-androstane-steroids for the estradiol-receptor in human myometrial and mammary cancer tissue. Mol Cell Endocrinol 1:27-34, 1977.
    • (1977) Mol Cell Endocrinol , vol.1 , pp. 27-34
    • Poortman, J.1    Vroegindewey-Jie, D.2    Thijssen, J.H.3    Schwarz, F.4
  • 46
    • 0019443294 scopus 로고
    • Actions and interactions of 85-androstene-3β,17β-diol and 17β-estradiol in the immature rat uterus
    • Van Doom LG, Poortman J, Thijssen JH, Schwarz F. Actions and interactions of 85-androstene-3β,17β-diol and 17β-estradiol in the immature rat uterus. Endocrinology 108:1587-1593, 1981.
    • (1981) Endocrinology , vol.108 , pp. 1587-1593
    • Van Doom, L.G.1    Poortman, J.2    Thijssen, J.H.3    Schwarz, F.4
  • 47
    • 0031465938 scopus 로고    scopus 로고
    • Dehydroepiandrosterone stimulates the estrogen response element
    • Bruder JM, Sobek L, Oettel M. Dehydroepiandrosterone stimulates the estrogen response element. J Steroid Biochem Mol Biol 62:421-466, 1997.
    • (1997) J Steroid Biochem Mol Biol , vol.62 , pp. 421-466
    • Bruder, J.M.1    Sobek, L.2    Oettel, M.3
  • 50
    • 0017576430 scopus 로고
    • Dehydroepiandrosterone (DHA)-induced precocious ovulation: Correlative changes in blood steroids, gonadotropins, and cytosol estradiol receptors of anterior pituitary gland and hypothalamus
    • Parker CR, Mahesh VB. Dehydroepiandrosterone (DHA)-induced precocious ovulation: Correlative changes in blood steroids, gonadotropins, and cytosol estradiol receptors of anterior pituitary gland and hypothalamus. J Steroid Biochem Mol Biol 8:173-177, 1977.
    • (1977) J Steroid Biochem Mol Biol , vol.8 , pp. 173-177
    • Parker, C.R.1    Mahesh, V.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.