Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model

Carcinogenesis

Volumn 19, Issue 8, 1998, Pages 1345-1351

  Lubet, Ronald A ^a   Steele, Vernon E ^a   DeCoster, Roland ^b   Bowden, Charles ^b   You, Ming ^c   Juliana, M Margaret ^d   Eto, Isao ^e   Kelloff, Gary J ^a   Grubbs, Clinton J ^e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE INHIBITOR; METHYLNITROSOUREA; SOMATOMEDIN C; TESTOSTERONE; VOROZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER MODEL; CHEMOPROPHYLAXIS; CONTROLLED STUDY; FEMALE; INTRAGASTRIC DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANTINEOPLASTIC AGENTS; AROMATASE INHIBITORS; BODY WEIGHT; CARCINOGENS; DRUG ADMINISTRATION SCHEDULE; DRUG SCREENING ASSAYS, ANTITUMOR; ESTRADIOL; ESTRUS; FEMALE; GENES, RAS; INSULIN-LIKE GROWTH FACTOR I; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; TRIAZOLES;

EID: 0031682251     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.8.1345     Document Type: Article

References (35)

1. Parl,F.F. and Wagner,R.K. (1981) The histopathologic evaluation of human breast cancer correlation with estrogen receptor values. Cancer, 46, 362-367.
2. Boyd,S. (1900) On oophorectomy in cancer of the breast. Br. Med. J., ii, 1167-1171.
3. Early Breast Cancer Trialist's Collaborative Group (1988) Effects of adjuvant tamoxifen and cytotoxic therapy on mortality in early breast cancer. N. Eng. J. Med., 319, 1681-1692.
4. Fisher,B., Costantino,J., Redmond,C., et al. (1989) A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors. N. Eng. J. Med., 320, 479-482.
5. Cole,P.A. and Robinson,C.H. (1990) Mechanism and inhibition of the cytochrome P-450 aromatase. J. Med. Chem., 33, 2933-2942.
6. Hoffken,K., Kempf,H., Miller,A.A., Miller,B., Schmidt,C.G., Faber,P. and Kley,H.K. (1986) Aminoglutethimide without hydrocortisone in the treatment of postmenopausal patients with advanced breast cancer. Cancer Treat. Rep., 70, 1153-1160.
7. Gale,D.E. (1982) Treatment of advanced breast cancer with aminoglutethimide. A 14-year experience. Cancer Res., 42 (suppl.), 3389-3396.
8. Cash,R., Brough,A., Cohen,M. and Satch,P.S. (1967) Aminoglutethimide as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial. J. Clin. Endocrinol. Metabol., 27, 1239-1248.
9. De Coster,R., Wouters,W., Bowden,C., Vanden-Bossche,H. and Bruynseels,J. (1990) New non-steroidal aromatase inhibitors: Focus on R 76713. J. Steroid Biochem. Mol. biol., 37, 335-341.
10. Wouters,W., De Coster,R., van Dun,J., et al. (1990) Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R 83842 on steroid biosynthesis in vitro and in vivo. J. Steroid Biochem. Mol. Biol., 37, 1049-1054.
11. De Coster,R., VanGinckel,R., Callens,M., Goeminne,N. and Janssens,B. (1992) Antitumoral and endocrine effects of (+) vorozole in rats bearing dimethylbenzanthracene induced mammary tumors. Cancer Res., 52, 1240-1244.
12. Goss,P.E., Clark,R.M., Ambus,U., et al. (1995) Phase II study of vorozole (R82842) a new aromatase inhibitor in postmenopausal women with advanced breast cancer in progression on tamoxifen. Clin. Cancer Res., 1, 287-294.
13. Lubet,R.A., Steele,V.E., Casebolt,T.L., Eto,I., Kelloff,G.J. and Grubbs,C.J. (1994) Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats. Carcinogenesis, 15, 2775-2780.
14. McCormick,D.L., Adamowski,C.B., Fiks,A. and Moon,R.C. (1981) Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea. Cancer Res., 41, 1690-1694.
15. Young,S. and Hallowes,R.C. (1973) Tumors of the mammary gland. In Pathology of Tumors in Laboratory Animals, Vol. 5. IARC Scientific Publications, Lyon, pp. 31-73.
16. Peto,J. (1988) The calculation and interpretation of survival curves. In Buyse,M.E. (ed.) Cancer Clinical Trials: Methods and Practice. Oxford University Press, Oxford, UK, pp. 361-380.
17. Armitage,P. (1966) The chi-square test for heterogeneity of proportion after adjustment for stratification. J. R Stat. Soc. B, 28, 150-163.
18. Lubet,R.A., Gordon,G.B., Prough,R.A., et al. (1998) Modulation of methylnitrosourea-induced breast cancer in Sprague-Dawley rats by dehydroepiandrosterone: Effects of limited exposure, effects of peroxisomal enzymes. Cancer Res., 58, 921-926.
19. Uziely,B., Lewin,A., Brufman,G., Dorembus,D. and Mor-Yosef,S. (1993) The effect of tamoxifen on the endometrium. Breast Cancer Res. Treat., 26, 101-105.
20. Williams,G.M., Latropoulos,M.J., Djordjevic,M.V. and Kaltenberg,O.P. (1993) The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis, 14, 315-317.
21. Bilmoria,M., Assikis,V. and Jordan,V. (1996) Should adjuvant tamoxifen therapy be stopped at 5 years? Cancer J., 2, 140-150.
22. Early Breast Cancer Trialist's Collaborative Group (1992) Systemic treatment of early breast cancer by hormonal, cytotoxic or immune therapy: 133 randomized trials involving 31 000 recurrences and 24 000 deaths among 750 000 women. Lancet, 339, 71-85.
23. Jonat,W., Howell,A., Blomqvist,C., et al (1996) A randomized trial comparing two doses of the new selective aromatase inhibitor Anastrozole (Arimidex) with Megestrol Acetate in postmenopausal patients with advanced breast cancer. Eur. J. Cancer, 32, 404-412.
24. Wouters.W., DeCoster,R., Krekels,M., et al. (1989) R 76713, a new specific non-steroidal aromatase inhibitor. J. Steroid. Biochem., 32, 781-788.
25. Lahti,E.I., Knip,M. and Laatekainen,T.J. (1994) Plasma insulin like growth factor-1 and its binding proteins 1 and 3 in postmenopausal patients with breast cancer receiving long-term tamoxifen. Cancer, 74, 618-624.
26. Huynh,H.T., Tetenes,E., Wallace,L. and Pollak,M. (1993) In vivo inhibition of IGF-1 gene expression by tamoxifen. Cancer Res., 53, 1727-1730.
27. Gottardis,M.M. and Jordan,V.C. (1981) The antitumor action of keoxifene and tamoxifen in the N-nitrosomethylurea induced rat mammary tumor model. Cancer Res., 47, 4020-4024.
28. Russo,I.H. and Russo,J. (1996) Mammary gland neoplasia in long-term rodent studies. Environ. Health Perspect., 104, 938-967.
29. Huggins,C. (1965) Two principles in endocrine therapy of cancers: hormone deprival and hormone interference. Cancer Res., 25, 1163-1167.
30. Sgamboto,A., Han,E.K., Zhang,Y.J., Moon,R.C. and Weinstein,I. (1995) Deregulated expression of cyclin D1 and other cell cycle related genes in carcinogen induced rat mammary tumors. Carcinogenesis, 16, 2193-2198.
31. Sukumar,S., Notario,V., Martin-Zanca,D. and Barbacid,M. (1983) Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature, 306,658-661.
32. Johnston,S.R., Smith,I.E., Doody,D., Jacobs,S., Robertson,H. and Dowsett,M. (1994) Clinical and endocrine effects of the oral aromatase inhibitor vorozole in postmenopausal patients with advanced breast cancer. Cancer Res., 54, 5875-5881.
33. Simpson,E.R. and Zhao,Y. (1996) Estrogen biosynthesis in adipose tissue. Significance in breast cancer development. Ann. NY Acad. Sci., 784, 18-26.
34. Dowsett,M., Lee,K., Macaulay,V.M., Detre,S., Rowlands,M. and Grimshaw,R. (1996) The control and biological importance of intratumoral aromatase in breast cancer. J. Steroid Biochem. Mol. Biol., 56, 145-150.
35. Onate,S.A., Tsai,S.Y., Tsai,M.J. and O'Malley,B.W. (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science, 270, 1354-1357.