Platelet kinetics in dogs treated with a glycoprotein IIb/IIIa peptide antagonist

Toxicologic Pathology

Volumn 28, Issue 2, 2000, Pages 310-316

  Weiss, Douglas J ^a   Mirsky, Michael L ^b   Evanson, Oral A ^a   Fagliari, Jose ^a   McClenahan, David ^a   McCullough, Bruce ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b SANOFI   (France)

Author keywords

platelet survival; RPR 109891; scintigraphy; Thrombocytopenia

Indexed keywords

FIBRINOGEN RECEPTOR ANTAGONIST; N ETHYL N [4 (4 PIPERIDINYL)BUTYRYL]GLYCYLASPARTYL 3 CYCLOHEXYLALANINAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG EFFECT; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOSIS;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PLATELETS; DOGS; FEMALE; HALF-LIFE; KINETICS; PEPTIDES; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET COUNT; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; RADIONUCLIDE IMAGING; THROMBOCYTOPENIA;

ANIMALIA; CANIS FAMILIARIS;

EID: 0034075878     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800211     Document Type: Article

References (38)

1. Acuirre FV, Topol EJ, Ferguson JJ, Anderson K., Blankenship JC, Heuser RR, Sigmon K., Taylor M., Gottlieb R. (1995). Bleeding complications with the chimeric antibody to platelet glycoprotein IIb/IIIa integrin in patients undergoing percutaneous coronary intervention. Circulation 91: 2882-2891.
2. Alexander JH, Harrington RA (1998). Recent antiplatelet drug trails in the acute coronary syndromes—Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT. Drug 56: 965-976.
3. Badenhorst PN, Lotter MG, Heyns AD, Van Reenan OR, Herbst C., Peters H., Kotze HF, Duyvene LJ, Minnaar PC (1982). The influence of the collection injury on the survival and distribution of indium-111-labeled canine platelets. Br J Haematol 52: 233-240.
4. Badenhorst PN, Peters H. (1986). Methodology of platelet imaging. In: Platelet Kinetics and Imaging, Heyns AP, Badenhorst PN, Lotter MG (eds). CRC Press, Boca Raton, FL, pp 159-168.
5. Bednar B., Cummingham ME, McQueen CF (1997). Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine-glycine-aspartatic acid ligands in binding to glycoprotein IIb/IIIa on platelets. Cytometry 28: 58-65.
6. Belcher EH, Berlin NI, Eernisse JG, Garby L., Heimpel H., Lea M., Lewis SM, McIntyre PA, Mollison PI, Murphy EA, Najean Y., Pettit JE, Szuri L. (1977). Recommended methods for radioisotope platelet survival studies. Blood 50: 1137-1144.
7. Cannon C., McCabe CH, Borzak S. (1997). Randomized trial of an oral platelet glycoprotein IIb/IIIa antagonist, sibrafiban, in patients after an acute coronary syndrome: Results of the TIMI 12 trial. Circulation 97: 340-349.
8. Collier BS (1998). Platelet IIb/IIIa antagonists: The first anti-integrin receptor therapeutics. J Clin Invest 99: 1467-1471.
9. Coller BS (1997). GPIIb/IIIa antagonists: Pathophysiology and therapeutic insights from c7E3 Fab. Thromb Haemostasis 23: 730-736.
10. Collier BS, Folts JD, Scudder LE, Smith SR (1986). Antithrombotic effects of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model. Blood 68: 783-786.
11. Dore M., Hawkins HK, Entman Smith CW (1993). Production of a monoclonal antibody against canine GMP-140 (P-selectin) and studies of its vascular distribution in canine tissues. Vet Pathol 30: 213-222.
12. Du X., Ginsberg MH (1997). Integrin αIIΒ3 and platelet function. Thromb Haemostasis 78: 96-100.
13. Du X., Plow EF, Frelinger AL, O'Toole TE, Loftus JC, Ginsberg MA (1991). Ligands “activate” integrin αIIbβ3 (platelet GPIIb/IIIa). Cell 65: 409-416.
14. Escolar G., Leistikow E., White JG (1989). The fate of the open canalicular system in surface and suspension-activated platelets. Blood 74: 1983-1988.
15. Foster RH, Wiseman LR (1998). ABCIXIMAB—A review of its use in ischemic heart disease. Drugs 56: 629-665.
16. Gawaz M., Ruf A., Neumann FJ, Pogatsa-Murry G., Dickfeld T., Zohlnhofer D., Schomig A. (1998). Effects of glycoprotein IIb-IIIa receptor antagonism on platelet membrane glycoproteins after coronary stent placement. Thromb Haemostasis 80: 994-1001.
17. Giugliano RP (1998). Drug-induced thrombocytopenia—Is it a serious concern for glycoprotein IIbIIIa receptor inhibitors. J Thromb Thrombolysis 5: 191-202.
18. Greenberg JP, Packham MA, Guccione MA, Guccione MA, Rand ML, Reimers HJ, Mustard JF (1979). Survival of rabbit platelets treated in vitro with chymotrypsin, plasmin, trypsin, or neuraminidase. Blood 53: 916-922.
19. Gulba DC, Huber K., Moll S., Dietz R. (1998). Platelet inhibition-New agents, new strategies, new trails. Fibrinolysis Proteolysis 12: 13-23.
20. Hubert M., Kunicki TJ, Bihour C., Winckler J., Nurden AT (1996). Visualization of activation-dependent epitopes on glycoprotein IIb/IIIa complexes of platelets stimulated by thrombin-immunogold staining of ultrathin sections. Semin Thromb Haemostasis 22: 279-288.
21. Hughes A., Tonks RS (1962). Intravascular platelet clumping in rabbits. J Pathol Bacteriol 84: 379-390.
22. Itoh H., Cicala C., Douglas GJ, Page CP (1997). Platelet accumulation induced by bacterial endotoxin in rats. Thromb Res 83: 405-419.
23. Kotze HF, van Wyk V., Badenhorst PN, Heyns du P., Roodt JP, Lotter MG (1993). Influence of platelet membrane sialic acid and platelet-associated IgG on aging and sequestration of blood platelets in baboons. Thromb Haemostasis 70: 676-680.
24. Kotze HF, Wessels P., Peters H. (1986). Kinetics, redistribution, and sites of sequestration of normal platelets. In: Platelet Kinetics and Imaging, Heyns AP, Badenhorst PN, Lotter MG (eds). CRC Press, Boca Raton, FL, pp 107-123.
25. Kristensen AT, Weiss DJ, Klausner J. (1994). Detection of antiplatelet antibody in the dog: Comparison of microscopic and fluorescence-activated cell sorter detection methods. Am J Vet Res 55: 1111-1114.
26. Leistikow EA, Barnhart MI, Escolar G., White J. (1990). Receptor-ligand complexes are cleared to the open canalicular system of surface-activated platelets. Br J Haematol 74: 93-100.
27. Lotter MG (1986). Methodology of platelet imaging. In: Platelet Kinetics and Imaging, Heyns AP, Badenhorst PN, Lotter MG (eds). CRC Press, Boca Raton, FL, pp 35-72.
28. Mak KH, Tan Ath, Chan C., Koh TH, Topol EJ (1998). The clinical impact of platelet glycoprotein IIb/IIIa receptor blockade in cardiovascular medicine. Jpn Circ J 62: 233-243.
29. Packhan MA, Guccione MA, Kinlough-Rathbone RL, Mustard JF (1980). Platelet sialic acid and platelet survival after aggregation by ADP. Blood 56: 876-883.
30. Peter K., Schwarz M., Ylanne J., Kohler B., Moser M., Nordt T., Salbach P., Kubler W., Bode C. (1998). Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (α 2bβ3) inhibitors. Blood 92: 3240-3249.
31. Phillips DR, Charo IF, Parise LV, Fitzgerald LA (1988). The platelet membrane glycoprotein IIb-IIIa complex. Blood 71: 831-843.
32. Schmitz G., Rothe G., Ruf A., Barlage S., Tschope D., Clemetson KJ, Goodal AH, Michelson AD, Nurden AT, Shankey TV (1998). European working group on clinical cell analysis: Consensus protocol for the flow cytometric characterization of platelet function. Thromb Haemostasis 79: 885-896.
33. Shattil S., Cunningham M., Hoxie JA (1987). Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies. Blood 70: 307-315.
34. Shattil SJ, Kashiwagi H., Pampori N. (1998). Integrin signaling: The platelet paradigm. Blood 92: 2645-2657.
35. Thakur ML, Walsh L., Joist JH (1976). Indium-111-labeled human platelets: Studies on preparation and evalution of in vitro and in vivo functions. Thromb Res 9: 345-359.
36. Vorchheimer DA, Fluster V. (1998). Oral platelet glycoprotein IIb/IIIa receptor antagonists: The present challenge is safety. Circulation 97: 312-321.
37. Weiss DJ, Evanson OA, Wells RE (1997). Evaluation of arginine-glycine-aspartate-containing peptides as inhibitors of equine platelet function. Am J Vet Res 58: 457-460.
38. Weiss DJ, Geor RJ, Johnston G., Trent AM (1994). Microvascular thrombosis associated with onset of acute laminitis in ponies. Am J Vet Res 55: 606-612.