Visualization of activation-dependent epitopes on glycoprotein IIb-IIIa complexes of platelets stimulated by thrombin: Immunogold staining of ultrathin sections

Seminars in Thrombosis and Hemostasis

Volumn 22, Issue 3, 1996, Pages 279-288

  Humbert, Michel ^b   Kunicki, Thomas J ^b   Bihour, Claude ^b   Winckler, Joëlle ^b   Nurden, Alan T ^b   Nurden, Paquita ^a  

^a HAUT LÉVÊQUE HOSPITAL   (France)

^b NONE

Author keywords

Activation dependent epitopes; GP IIb IIIa comlexes,; Immunogold staining; Platelets; Thrombin

Indexed keywords

EPITOPE; FIBRINOGEN; FIBRINOGEN RECEPTOR; PADGEM PROTEIN; THROMBIN;

AMINO ACID SEQUENCE; ARTICLE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGOLD STAINING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; THROMBOCYTE; THROMBOCYTE MEMBRANE;

EID: 0029977769     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-999020     Document Type: Article

References (41)

1. Hynes RO: Integrins: a family of cell surface receptor. Cell 48:549-554, 1987.
2. Kieffer N, DR Phillips: Platelet membrane glycoproteins: functions in cellular interactions. Annu Rev Cell Biol 6:329-357, 1990.
3. Nurden AT: Human platelet membrane glycoproteins. In: Bloom AL, CD Forbes, DP Thomas, EGD Tuddenham (eds): Hemostasis and Thrombosis, 3rd ed. Churchill Livingstone, Edinburgh, 1994, pp 115-165.
4. Wencel-Drake JD, EF Plow, TJ Kunicki, VL Woods, DM Keller, MH Ginsberg: Localization of internal pools of membrane glycoproteins involved in platelet adhesive responses. Am J Pathol 124:324-334, 1986.
5. Cramer EM, GF Savidge, W Vainchenker, MC Berndt, D Pidard, JP Caen, JM Masse, J Breton-Gorius: Alpha granule pool of glycoprotein IIb/IIIa in normal and pathologic platelets and megakaryocytes. Blood 75:1220-1227, 1990.
6. Heilmann E, P Hourdillé, A Pruvost, A Paponneau, AT Nurden: Thrombin-induced platelet aggregates have a dynamic structure. Time-dependent redistribution of glycoprotein IIb/IIIa complexes and secreted adhesive proteins. Arterioscler Thromb 11:704-718, 1991.
7. Suzuki H, S Nakamura, T Tanaka, K Tanoue: Immunocytochemical evidence for the translocation of α-granule membrane glycoprotein IIb/IIa of human platelets to the surface membrane during the release reaction. Histochemistry 97:381-388, 1992.
8. Shattil SJ, JA Hoxie, M Cunningham, LF Brass: Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem 260:11107-11114, 1985.
9. Tomiyama Y, T Tsubakio, RS Piotrowicz, Y Kurata, JC Loftus, TJ Kunicki: The Arg-Gly-Asp (RGD) recognition site of platelet glycoprotein IIb-IIIa on nonactivated platelets is accessible to high-affinity macromolecules. Blood 79:2303-2312, 1992.
10. Taub R, RJ Gould, VM Garsky, TM Ciccarone, J Hoxie, PA Friedman, SJ Shattil: A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem 264:259-265, 1989.
11. Frelinger AL, SCT Lam, EF Plow, MA Smith, JC Loftus, MH Ginsberg: Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J Biol Chem 263:12397-12402, 1988.
12. Abrams SC, N Ellison, AZ Budzinski, SJ Shattil: Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 75:128-138, 1990.
13. Charo IF, L Nannizzi, DR Phillips, MA Hsu, RM Scarborough: Inhibition of fibrinogen binding to GPIIb-IIIa by a GPIIIa peptide. J Biol Chem 266:1415-1421, 1991.
14. 3 (GP IIb/ IIIa) and inhibit ligand binding. J Biol Chem 268:6870-6873, 1993.
15. 3 in resting and activated human platelets determined by expression of a novel class of ligand-induced binding site (LIBS) recognized by monoclonal antibody AP6. Blood, In press.
16. Hourdillé P, E Heilmann, R Combrié, J Winckler, KJ Clemetson, AT Nurden: Thrombin induces a rapid redistribution of glycoprotein Ib-IX complexes within the membrane. Blood 76:1503-1510, 1990.
17. Piotrowicz RS, TJ Kunicki: Identification of an activation-dependent epitope on platelet glycoprotein IIIa. (Abst.) J Cell Biol 111:403a, 1990.
18. Gralnick HR, S Williams, L McKeown, G Connaghan, B Shafer, K Hansmann, M Vail, J Fenton: Endogenous platelet fibrinogen surface expression on activated platelets. J Lab Clin Med 118:604-613, 1991.
19. Zamarron C, MH Ginsberg, EF Plow: Monoclonal antibodies specific for a conformationally altered state of fibrinogen. Thromb Haemostas 64:41-46, 1990.
20. Tokuyasu KT: Immunochemistry on ultrathin frozen sections. Histochem J 12:381-403, 1980.
21. Hourdillé P, HR Gralnick, E Heilmann, A Derlon, AM Ferrer, G Vezon, AT Nurden: Von Willebrand factor bound to glycoprotein Ib is cleared from the platelet surface after platelet activation by thrombin. Blood 79:2011-2021, 1992.
22. Kleiman NS, AE Raizner, R Jordan, AL Wang, D Norton, KF Mace, A Joshi, BS Coller, HF Weisman: Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: Implications for inhibition of the internal pool of GP IIb/IIIa receptors. J Am Coll Cardiol 26:1665-1671, 1995.
23. Woods VL, LE Wolff, DM Keller: Resting platelets contain a substantial centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some hut not other extracellular proteins. J Biol Chem 261:15242-15251, 1986.
24. Harrison P, B Wilbourn, N Debili, W Vainchenker, J Breton-Gorius, AS Lawrie, JM Masse, GF Savidge, EM Cramer: Uptake of plasma fibrinogen into the alpha granules of human megakaryocytes and platelets. J Clin Invest 84:1320-1324, 1989.
25. Handagama P, DF Bainton, Y Jacques, MT Conn, RA Lazarus, MA Shuman: Kristin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules. J Clin Invest 91:193-200, 1993.
26. 3 (glycoprotein IIb/IIIa). Blood 82:135-138, 1993.
27. Behnke O: Coated pits and vesicles transfer plasma components to platelet granules. Thromb Haemostas 62:718-722, 1989.
28. Painter RG, KN Prodouz, W Gaarde: Isolation of a subpopulation of glycoprotein IIb-IIIa from platelet membranes that is bound to membrane actin. J Cell Biol 100:652-657, 1985.
29. 3 (platelet glycoprotein IIb/ IIIa) helps define a ligand binding site. J Biol Chem 267:3789-3794, 1992.
30. Lanza F, A Stierle, D Fournier, M Morales, G Andre, AT Nurden, JP Cazenave: A new variant of Glanzmann's thrombasthenia (Strasbourg I). J Clin Invest 89:1995-2004, 1992.
31. 3) Arg214 by Trp. Hum Mol Genet 2:2179-2180, 1993.
32. Kouns WC, B Steiner, TJ Kunicki, S Moog, J Jutzi, LK Jennings, JP Cazenave, F Lanza: Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombastenia. Blood 84:1108-1115, 1994.
33. Courtois G, JJ Ryckewaert, VL Woods, MH Ginsberg, EF Plow, GA Marguerie: Expression of intracellular fibrinogen on the surface of stimulated platelets. Eur J Biochem 159:61-67, 1986.
34. Legrand C, V Dubernard, AT Nurden: Studies on the mechanism ol expression of secreted fibrinogen on the surface of activated human platelets. Blood 73:1226-1234, 1989.
35. van Willigen G, J-WN Akkerman: Regulation of glycoprotein IIb/ IIIa exposure on platelets stimulated with α-thrombin. Blood 79:82-89, 1992.
36. Topol EJ, RM Califf, HF Weisman, SG Ellis, JE Tcheng, S Worley, R Ivanhoe, BS George, D Fintel, M Weston, K Sigmon, KM Anderson, KL Lee, JT Willerson: Randomized trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. Lancet 343:881-888, 1984.
37. Escolar G, E Leistikow, JG White: The fate of the open canalicular system in surface and suspension-activated platelets. Blood 74: 1983-1988, 1989.
38. Behnke O, D Bray: Surface movements during the spreading of blood platelets. Eur J Cell Biol 46:207-216, 1988.
39. White JG, G Escolar: Current concepts of platelet membrane response to surface activation. Platelets 4:175-189, 1993.
40. Hartwig JH: Mechanisms of actin rearrangements mediating platelet activation. J Cell Biol 118:1421-1442, 1992.
41. Bertagnolli ME, MC Beekerle: Evidence for the selective association of a subpopulation of GP IIb/IIIa with the actin cytoskeletons of thrombin-activated platelets. J Cell Biol 121:1329-1342, 1993.