Regulation of the yeast INO1 gene: The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol

Genetics

Volumn 154, Issue 4, 2000, Pages 1485-1495

  Graves, J Anthony ^a   Henry, Susan A ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL;

ARTICLE; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; PRIORITY JOURNAL; YEAST;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, REGULATOR; INOSITOL; MUTATION; MYO-INOSITOL-1-PHOSPHATE SYNTHASE; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE;

EID: 0034075621     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. AMBROZIAK, J., and S. A. HENRY, 1994 INO2 and INO4 gene products, positive regulators of phospholipid biosynthesis in Saccharomyces cerevisiae, form a complex that binds to the INO1 promoter. J. Biol. Chem. 269: 15344-15349.
2. ARNDT, K. M., S. RICUPERO-HOVASSE and F. WINSTON, 1995 TBP mutants defective in activated transcription in vivo. EMBO J. 14: 1490-1497.
3. ASHBURNER, B. P., and J. M. LOPES, 1995a Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes. Mol. Cell. Biol. 15: 1709-1715.
4. ASHBURNER, B. P., and J. M. LOPES. 1995b Regulation of yeast phospholipid biosynthesis involves two superimposed mechanisms. Proc. Natl. Acad. Sci. USA 92: 9722-9726.
5. BACHHAWAT, N., Q. OUYANG and S. A. HENRY, 1995 Functional characterization of an inositol-sensitive upstream activation sequence in yeast: a cis-regulatory element responsible for inositol-choline mediated regulation of phospholipid biosynthesis. J. Biol. Chem. 270: 25087-25095.
6. BAILIS, A. M., M. A. POOLE, G. M. CARMAN and S. A. HENRY, 1987 The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance. Biol. Cell. Biol. 7: 167-176.
7. BAILIS, A. M., J. M. LOPES, S. D. KOHLWEIN and S. A. HENRY, 1992 cis and trans regulatory elements required for regulation of the CHO1 gene of Saccharomyces cerevisiae. Nucleic Acids Res. 20: 1411-1418.
8. BUTLER, E. T., and M. J. CHAMBERLIN, 1982 Bacteriophase SP6-specific RNA polymerase. I. Isolation and characterization of the enzyme. J. Biol. Chem. 257: 5772-5778.
9. COK, S. J., C. G. MARTIN and J. I. GORDON, 1998 Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae. Nucleic Acids Res. 26: 2865-2872.
10. COX, J. S., and P. WALTER, 1996 A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response. Cell 87: 391-404.
11. COX, J. S., R. E. CHAPMAN and P. WALTER. 1997 The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrain. Mol. Biol. Cell 8: 1805-1814.
12. CULBERTSON, M. R., and S. A. HENRY, 1975 Inositol-requiring mutants of Saccharomyces cerevisiae. Genetics 80: 23-40.
13. CULBERTSON, M. R., T. F. DONAHUE and S. A. HENRY, 1976 Control of inositol biosynthesis in Saccharomyces cerevisiae: inositol-phosphate synthetase mutants. J. Bacteriol. 126: 243-250.
14. ELION, E. A., and J. R. WARNER, 1984 The major promoter element of rRNA transcription in yeast lies 2 kb upstream. Cell 39: 663-673.
15. GRAVES, J. A., 1996 Analysis of the role of the OPH gene product in the negative regulation of the phospholipid biosynthetic pathway of Saccharomyces cerevisiae. Ph.D. Thesis, Biological Sciences, Carnegie Mellon University, Pittsburgh.
16. GREENBERG, M. L., B. REINER and S. A. HENRY, 1982 Regulatory mutations of inositol biosynthesis in yeast: isolation of inositol-excreting mutants. Genetics 100: 19-33.
17. GRIAC, P., M. J. SWEDE and S. A. HENRY, 1996 The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast. J. Biol. Chem. 271: 25692-25698.
18. HENRY, S. A., and J. L. PATTON-VOGT, 1998 Genetic regulation of phospholipid metabolism: yeast as a model eukaryote, pp. 133-179 in Progress in Nucleic Acid Research and Molecular Biology, edited by W. E. COHN and K. MOLDAVE. Academic Press, San Diego.
19. HIRSCH, J. P., and S. A. HENRY, 1986 Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol. Cell. Biol. 6: 3320-3328.
20. HUDAK, K. A., J. M. LOPES and S. A. HENRY, 1994 A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1). Genetics 136: 475-483.
21. JACKSON, J. C., and J. M. LOPES, 1996 The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression. Nucleic Acids Res. 24: 1322-1329.
22. JIRANEK, V., J. A. GRAVES and S. A. HENRY, 1998 Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism. Microbiology 144: 2739-2748.
23. KADOSH, D., and K. STRUHL, 1998 Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol. Cell. Biol. 18: 5121-5127.
24. KASTEN, M. M., S. DORLAND and D. J. STILLMAN, 1997 A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Mol. Cell. Biol. 17: 4852-4858.
25. KLIG, L. S., M. J. HOMANN, G. M. CARMAN and S. A. HENRY, 1985 Coordinate regulation of phospholipid biosynthesis in Saccharomyces cerevisiae: pleiotropically constitutive opi1 mutant. J. Bacteriol. 162: 1135-1141.
26. LIU, Q., S. E. GABRIEL, K. L. ROINICK, R. D. WARD and K. M. ARNDT, 1999 Analysis of TFIIA function in vivo: evidence for a role in TATA-binding protein recruitment and gene-specific activation. Mol. Cell. Biol. 19: 8673-8685.
27. LOFWY, B. S., and S. A. HENRY, 1984 The INO2 and INO4 loci of Saccharomyces cerevisiae are pleiotropic regulatory genes. Mol. Cell. Biol. 4: 2479-2485.
28. LOEWY, B., J. HIRSCH, M. JOHNSON and S. HENRY, 1986 Coordinate regulation of phospholipid synthesis in yeast, pp. 551-565 in Yeast Cell Biology, edited by J. HICKS, Alan R. Liss, Inc., New York.
29. LOPES, J. M., and S. A. HENRY, 1991 Interaction of trans and cis regulatory elements in the INO1 promoter of Saccharomyces cerevisiae. Nucleic Acids Res. 19: 3987-3994.
30. NIELSEN, D. A., and D. J. CHAPIRO, 1986 Preparation of capped RNA transcripts using T7 RNA polymerase. Nucleic Acids Res. 14: 5936.
31. NIKOLOFF, D. M., and S. A. HENRY, 1994 Functional chararterization of the INO2 gene of Saccharomyces cerevisiae. J. Biol. Chem. 269: 7402-7411.
32. INO containing genes of yeast. Genetics 152: 89-100.
33. PATTON-VOGT, J. L., and S. A. HENRY, 1998 GIT1, a gene encoding a novel transporter for glycerophosphoinositol in Saccharomyces cerevisiae. Genetics 149: 1707-1715.
34. PATTON-VOGT, J. L., P. GRIAC, A. SREENIVAS, V. BRUNO, S. DOWD et al., 1997 Role of the yeast phosphatidylinositol/phosphatidylcholine transfer protein (Sec14p) in phosphatidylcholine turnover and INO1 regulation. J. Biol. Chem. 272: 20873-20883.
35. PELHAM, H. R., and R. J. JACKSON, 1976 An efficient mRNA-dependent translation system from reticulocyte lysates. Eur. J. Biochem. 67: 247-256.
36. PETERSON, C. L., and I. HERSKOWITZ, 1992 Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription. Cell 68: 573-583.
37. PETERSON, C. L., A. DINGWALL and M. P. SCOTT, 1994 Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proc. Natl. Acad. Sci. USA 91: 2905-2908.
38. RUNDLETT, S. E., A. A. CARMEN, N. SUKA, B. M. TURNER and M. GRUNSTEIN, 1998 Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392: 831-835.
39. SANTISTEBAN, M. S., G. ARENTS, E. N. MOUDRIANAKIS and M. M. SMITH, 1997 Histone octamer function in vivo: mutations in the dimer-tetramer interfaces disrupt both gene activation and repression. EMBO J. 16: 2493-2506.
40. SCAFE, C., D. CHAO, J. LOPES, J. P. HIRSCH, S. HENRY et al., 1990 RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals. Nature 347: 491-494.
41. SCHÜLLER, H. J., R. SCHORR, B. HOFFMAN and E. SCHWEIZER, 1992 Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a transactivator of fatty acid synthase genes FAS1 and FAS2 from Saccharomyces cerevisiae. Nucleic Acids Res. 20: 5955-5961.
42. SCHWANK, S., R. EBBERT, K. RAUTENSTRAUSS, E. SCHWEIZER and H.-J. SCHULLER, 1995 Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res. 23: 230-237.
43. SHERMAN, F., G. R. FINK and C. W. LAWRENCE, 1978 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. SHIRRA, M. K., and K. M. ARNDT, 1999 Evidence for the involvement of the Glc7-Reg1 phosphatase and the Snf1-Snf4 kinase in the regulation of INO1 transcription in Saccharomyces cerevisiae. Genetics 152: 73-87.
45. SREENIVAS, A., J. L. PATTON-VOGT, V. BRUNO, P. GRIAC and S. A. HENRY, 1998 A role for phospholipase D (Pld1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J. Biol. Chem. 273: 16635-16638.
46. SUN, Z.-W., and M. HAMPSEY, 1999 A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulation silencing in Saccharomyces cerevisiae. Genetics 152: 921-932.
47. WAGNER, C., M. BLANK, B. STROHMANN and H.-J. SCHÜLLER, 1999 Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Yeast 15: 843-854.
48. WHITE, M. J., J. P. HIRSCH and S. A. HENRY, 1991 The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper. J. Biol. Chem. 266: 863-872.