Investigation of the role of the cerebellum in the myoclonic-like movement disorder exhibited by tottering mice

Movement Disorders

Volumn 15, Issue SUPPL. 1, 2000, Pages 53-59

  Abbott, Louise C ^a   Bump, Melissa ^a   Brandl, Amy ^a   De Laune, Scarlett ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Calcium ion channel; Cerebellar cortical lesion; Climbing fiber; Deep cerebellar nuclei; Granule cell; Parallel fiber; Purkinje cell

Indexed keywords

CALCIUM CHANNEL; NEUROTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CEREBELLUM NUCLEUS; CEREBELLUM VERMIS; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; MALE; MOUSE; MOUSE MUTANT; MYOCLONUS; NONHUMAN; PETIT MAL; PRIORITY JOURNAL; PURKINJE CELL;

EID: 0034073538     PISSN: 08853185     EISSN: None     Source Type: Journal    
DOI: 10.1002/mds.870150710     Document Type: Conference Paper

References (37)

1. Noebels JL, Sidman RL. Inherited epilepsy: spike-wave and focal motor seizures in the mutant mouse tottering. Science 1979;204: 1334-1336.
2. Green MC, Sidman RL. Tottering - a neuromuscular mutation in the mouse. J Hered 1962;5:233-237.
3. Levitt P. Normal pharmacological and morphometric parameters in the noradrenergic hyperinnervated mutant mouse, 'tottering.' Cell Tissue Res 1988;252:175-180.
4. 1a) mice. Neuroscience 1999;90:717-728.
5. Kaplan BJ, Seyfried TN, Glaser GH. Spontaneous polyspike discharges in an epileptic mutant mouse (tottering). Exp Neurol 1979; 66:577-586.
6. Noebels JL. Mutational analysis of the inherited epilepsies. In: Delgado-Escueta AV, Ward AA, Woodbury DM, eds. Basic Mechanisms of the Epilepsies: Molecular and Cellular Approaches. New York, NY: Raven Press, 1986:97-114.
7. Kostopoulos G, Veronikis D, Efthimiou I. Caffeine blocks absence seizures in the tottering mutant mouse. Epilepsia 1987;28:415-420.
8. Levitt P, Noebels JL. Mutant mouse tottering: selective increase of locus coeruleus axons in a defined single-locus mutation. Proc Natl Acad Sci USA 1981;78:4630-4634.
9. Fletcher, Lutz CM, O'Sullivan TN, et al. Absence epilepsy in tottering mutant mice is associated with calcium channel detects. Cell 1996;87:607-617.
10. Augustine GJ, Charlton MP, Smith SJ. calcium action in synaptic transmitter release. Annu Rev Neurosci 1987;10:633-693.
11. Hille B. G protein-coupled mechanisms and nervous signalling. Neuron 1992;9:187-195.
12. Lipton SA, Kater SB. Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci 1989;12:265-270.
13. D'Angelo E, Rossi P, De Filippi G, Magistretti J, Taglietti V. The relationship between synaptogenesis and expression of voltage-dependent currents in cerebellar granule cells in situ. J Physiol (Paris) 1994;88:197-207.
14. IA calcium channel reflect similarities to neuronal Q-and P-type channels. Proc Natl Acad Sci USA 1994; 91:10576-10580.
15. Tsien RW, Lipscome D, Madison DV, Bley KR, Fox AP. Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci 1988;11:431-438.
16. 2+ channel diversity. Annu Rev Neurosci 1994;17:399-418.
17. 2+ channels. Trends Pharmacol Sci 1991;12:349-354.
18. 2+ channels: diversity of form and function. Curr Opin Neurobiol 1992;2:247-253.
19. 2+ channel currents in rat cerebellar granule neurons. J Neurosci 1995;15:2995-3012.
20. 2+ channels in supporting hippocampal synaptic transmission. Science 1994;264:107-111.
21. Mintz IM, Adams ME, Bean BP. P-type calcium channels in rat central and peripheral neurons. Neuron 1992a;9:85-95.
22. Mintz IM, Venema VJ, Swiderek KM, Lee TD, Bean BP, Adams ME. P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 1992b;355:827-829.
23. McDonough SI, Mintz IM, Bean, BP. Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA. Biophys J 1997;72:2117-2128.
24. Dove LS, Abbott LC, Griffith WH. Reduced P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice. J Neurosci 1998;18:7687-7699.
25. Lorenzon NM, Lutz CM, Frankel WN, Beam KG. Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J Neurosci 1998;18:4482-2289.
26. 1A subunits of brain calcium channels. J Neurosci 1995;15:6403-6418.
27. Mintz IM, Sabatini BL, Regehr WG. Calcium control of transmitter release at a cerebellar synapse. Neuron 1995;15:675-688.
28. Regehr WG, Mintz IM. Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses. Neuron 1994;12:605-613.
29. Snodgrass SR. Myoclonus: analysis of monoamine, GABA and other systems. FASEB J 1990;4:2775-2788.
30. Jaw SP, Hussong MJ, Matsumoto RR, Truong DD. Involvement of 5-HH2 receptors in posthypoxic myoclonus in rats. Pharmacol Biochem Behav 1994;49:129-131.
31. Welsh JP, Chang B, Menaker ME, Aicher SA. Removal of the inferior olive abolishes myoclonic seizures associated with a loss of olivary serotonin. Neuroscience 1998;82:879-897.
32. Isaacs KR, Abbott LC. Development of the paramedian lobule of the cerebellum in wild-type and tottering mice. Dev Neurosci 1992;14:386-393.
33. Isaacs KR, Abbott LC. Cerebellar volume decreases in the tottering mouse are specific to the molecular layer. Brain Res Bull 1995; 36:309-314.
34. Heckroth JA, Abbott LC. Purkinje cell loss from alternating sagittal zones in the cerebellum of leaner mutant mice. Brain Res 1994;658:93-104.
35. Kalivas PW, Duffy P, DuMars LA, Skinner C. Behavioral and neurochemical effects of acute and daily cocaine administration in rats. J Pharmacnl Exp Ther 1988;245:485-492.
36. Siri FM, Kauer CD. Plasma catecholamine measurements in resting and stressed conscious rats, using high performance liquid chromatography with electrochemical detection. Life Sci 1985;37: 1923-1931.
37. Altman J, Bayer SA. Development of the Cerebellar System. New York, NY: CRC Press, 1996.