Effects of 3-alkylamino-7-chloro-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1- dioxides on smooth muscle contraction

Pharmacy and Pharmacology Communications

Volumn 6, Issue 2, 2000, Pages 97-100

  Ouedraogo, R ^a   Fontaine, J ^a   Antoine, M H ^a   Pirotte, B ^b   Lebrun, P ^a,c  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 ALKYLAMINO 7 CHLORO 4H PYRIDO[2,3 E]1,2,4 THIADIAZINE 1,1 DIOXIDE; DIAZOXIDE; PINACIDIL; POTASSIUM CHANNEL; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

AORTA MEDIA; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG EFFECT; DRUG SYNTHESIS; ILEUM; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0034070426     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080800128735700     Document Type: Conference Paper

References (10)

1. Antoine, M.-H., Berkenboom, G., Fang, Z. Y., Fontaine, J., Herchuelz, A., Lebrun, P. (1992) Mechanical and ionic response of rat aorta to diazoxide. Eur. J. Pharmacol. 216: 299-306
2. Cook, N. S. (1988) The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. 9: 21-28
3. Cook, N. S., Quast, U. (1990) Potassium channel pharmacology. In: Cook, N. S. (ed.) Potassium Channels, Structure, Classification, Function and Therapeutic Potential, Ellis Horwood, Chichester, UK, pp 181-255
4. de Tullio, P., Pirotte, B., Lebrun, P., Fontaine, J., Dupont, L., Antoine, M.-H., Ouedraogo, R., Khelili, S., Maggeto, C., Masereel, B., Diouf, O., Podona, T., Delarge, J. (1996) 3-and 4-Substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships. J. Med. Chem. 39: 937-948
5. Godfraind, T., Miller, R., Wibo, M. (1986) Calcium antagonism and calcium entry blockade. Pharmacol. Rev. 38: 321-416
6. 86Rb fluxes and contractile activity in the rat aorta. Pharmacology 41: 36-48
7. Malaisse, W. J., Lebrun, P. (1990) Mechanisms of sulfonylurea-induced insulin release. Diabetes Care 13 (Suppl. 3): 9-17
8. Pirotte, B., de Tullio, P., Lebrun, P., Antoine, M.-H., Fontaine, J., Masereel, B., Schynts, M., Dupont, L., Herchuelz, A., Delarge, J. (1993) 3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: A new class of potassium channel openers? J. Med. Chem. 36: 3211-3213
9. Pirotte, B., Ouedraogo, R., de Tullio, P., Khelili, S., Somers, F., Boverie, S., Dupont, L., Fontaine, J., Damas, J., Lebrun, P. (1999) 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as a new class of potassium channel openers acting on vascular smooth muscle cells: design, synthesis and pharmacological evaluation. J. Med. Chem. In press
10. Quayle, J. M., Nelson, M. T., Standen, N. B. (1997) ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol. Rev. 77: 1165-1232