Clinical course of cardiomyopathy in HIV-infected patients with or without encephalopathy related to the myocardial expression of tumour necrosis factor-α and nitric oxide synthase

AIDS

Volumn 14, Issue 7, 2000, Pages 827-838

  Barbaro, Giuseppe ^a,d   Di Lorenzo, Gabriella ^a   Soldini, Maurizio ^a   Giancaspro, Giuseppe ^a   Grisorio, Benvenuto ^c   Pellicelli, Adriano M ^b   D'Amati, Giulia ^a   Barbarini, Giorgio ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b 2nd Division of Infectious Diseases   (Italy)

^c GENERAL HOSPITAL   (Italy)

^d NONE

Author keywords

Dilated cardiomyopathy; Encephalopathy; Factor alpha; HIV; Inducible nitric oxide synthase; Tumour necrosis

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; DIDANOSINE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; FUROSEMIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

ADULT; ADVERSE DRUG REACTION; ARTICLE; AUTOPSY; BRAIN BIOPSY; BRAIN DISEASE; CARDIOMYOPATHY; CAUSE OF DEATH; CEREBROSPINAL FLUID; CLINICAL EXAMINATION; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOMEGALOVIRUS; DISEASE COURSE; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART MUSCLE; HEART MUSCLE BIOPSY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RNA SEQUENCE; SCORING SYSTEM; VIRUS LOAD;

ADULT; AIDS DEMENTIA COMPLEX; CARDIOMYOPATHY, DILATED; CEREBRAL CORTEX; CEREBROSPINAL FLUID; ECHOCARDIOGRAPHY; FEMALE; HEART; HIV INFECTIONS; HIV-1; HUMANS; MALE; MYOCARDIUM; NITRIC OXIDE SYNTHASE; RNA, VIRAL; TUMOR NECROSIS FACTOR-ALPHA; VIRAL LOAD;

EID: 0034068219     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200005050-00009     Document Type: Article

References (51)

1. 1. Barbaro G, Di Lorenzo G, Grisorio B and the Gruppo Italiano per lo Studio Cardiologico dei pazienti aftetti da AIDS investigators. Cardiac involvement in the acquired immunodeficiency syndrome. A multicenter clinical-pathological study. AIDS Res Hum Retroviruses 1998, 14:1071-1077.
2. 2. Barbaro, G, Di Lorenzo G, Grisorio B for the Gruppo Italiano per lo Studio Cardiologico dei pazienti affetti da AIDS investigators. Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV positive patients. N Engl J Med 1998, 339:1093-1099.
3. 3. Lipshultz SE. Dilated cardiomyopathy in HIV-infected patients. [Editorial] N Engl J Med 1998, 339:1153-1155.
4. 4. Luginbuhl LM, Orav EJ, McIntosh K, Lipshultz SE. Cardiac morbidity and related mortality in children with HIV infection. J Am Med Assoc 1993, 269:2869-2875.
5. 5. Boller A, Al-Attar I, Orav EJ, Lipshultz SE. Cardiovascular morbidity and mortality in pediatric HIV infection. In Cardiology in AIDS. Edited by Lipshultz SE. New York: Chapman & Hall; 1998:77-94.
6. 2 HIV multicenter study. Circulation 1998, 97:1246-1256.
7. 7. Habib FM, Springall DR, Davies GJ, Oakley CM, Yacoub MH, Polak JM. Tumor necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet 1996, 347: 1151-1155.
8. 8. Satoh M, Nakamura M, Tamura G et al. Inducible nitric oxide synthase and tumor necrosis factor-alpha in myocardium in human dilated cardiomyopathy. J Am Coll Cardiol 1997, 29:716-724.
9. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 1992, 105:575-580.
10. 10. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathology and pharmacology. Pharmacol Rev 1991, 43: 109-142.
11. 11. Freeman GL, Colston JT, Zabalgoitia M, Chandrasekar B. Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis. Am J Physiol 1998, 274: 249-258.
12. 12. Kroncke KD, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthse and its product nitric oxide, a small molecule with complex biological activities. Biol Chem Hoppe-Seyler 1995, 376:327-343.
13. 13. Center for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR 1992, 41(RR-17):1-19.
14. 14. Himelman RB, Chung WS, Chernoff DN, Schiller NB, Hollander H. Cardiac manifestations of human immnunodeficiency virus infection: a two-dimensional echocardiographic study. J Am Coll Cardiol 1989, 13:1030-1036.
15. 15. Caves PK, Stinson EB, Billingham ME, Shumway NE. Percutaneous transvenous endomyocardial biopsy in human heart recipients: experience with a new technique. Ann Thorac Surg 1973, 16:325-336.
16. 16. Aretz HT. Myocarditis: the Dallas criteria. Hum Pathol 1987, 18:619-624.
17. 17. Beschorner WE, Baughman KL, Turnicky RP et al. HIV-associated myocarditis. Pathology and immunopathology. Am J Pathol 1990, 137:1365-1371.
18. 18. Schag CC, Heinrich RL, Ganz PA. Karnofsky performance status revisited:reliability, validity and guidelines. J Clin Oncol 1984, 2:187-193.
19. 19. Portegies P. AIDS dementia complex and neurological evaluation in HIV-1 infection. Transcript 1994, 36:12-18.
20. 20. Monno L, Di Stefano M, Zimatore GB et al. Measurement of viral sequences in cerebrospinal fluid of AIDS patients with cerebral white matter lesions using polymerase chain reaction. AIDS 1998, 12:581-590.
21. 21. Woods GL, Gutierrez Y. Diagnostic Pathology of Infectious Diseases. Philadelphia: Lea & Fabiger; 1993.
22. 22. Grody W, Cheng L, Lewis W. Infection of the heart by the human immunodeficiency virus. Am J Cardiol 1990, 66: 203-206.
23. 23. Conrad AJ, Schmid P, Syndulko K et al. Quantifying HIV-1 RNA using the polymerase chain reaction on cerebrospinal fluid and serum of seropositive individuals with and without neurologic abnormalities. J AIDS Hum Retrovirol 1995, 10:425-435.
24. 24. Cinque P, Vago L, Dahl H et al. Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients. AIDS 1996, 10:951-958.
25. 25. Armitage P, Berry G. Statistical Methods in Medical Research. Oxford: Blackwell Scientific; 1994.
26. 26. Cooper ER, Hanson C, Diaz C et al. Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. J Pediatr 1998, 132:808-812.
27. 27. McArthur JC. Neurologic manifestations of AIDS. Medicine 1987, 66:407-437.
28. 28. Levy RM, Bredesen DE, Rosenblum ML. Neurologic complications of HIV infection. Am Fam Physician 1990, 41:517-536.
29. 29. Simpson DM, Tagliati M. Neurologic manifestations of HIV-1 infection. Ann Intern Med 1994, 121:769-785.
30. 30. Plein D, van Camp G, Cosyns B, Alimenti A, Levy J, Vandenbossche JL. Cardiac and autonomic evaluation in a paediatric population with human immunodeficiency virus. Clin Cardiol 1999, 22:33-36.
31. 31. Barbaro G, Barbarini G. Cardiac manifestations of the acquired immunodeficiency syndrome. In AIDS und HIV-infektionen. Edited by Jager H. Landsberg: Ecomed Verlagsgesellschaft; 1999:1-16 Volume 4.
32. 32. Barbaro G, Di Lorenzo G, Soldini M et al. Vagal system impairment in human immunodeficiency virus-positive patients with chronic hepatitis C: does glutathione deficiency have a pathogenetic role? Scand J Gastroenterol 1997, 32:1261-1266.
33. 33. Kasten-Sportes C, Weinstein C. Molecular mechanisms of HIV cardiovascular disease. In Cardiology in AIDS. Edited by Lipshultz SE. New York: Chapman & Hall; 1998:265-282.
34. 34. Matsumori A. Cytokines in myocarditis and cardiomyopathy. Curr Opin Cardiol 1996, 11:302-309.
35. 35. Ehrenreich H, Rieckmann P, Sinowatz F et al. Potent stimulation of monocytic endothelin-1 production by HIV-1 glycoprotein. J Immunol 1993, 150:4601-4609.
36. 36. Zaragoza C, Ocampo C, Saura M et al. The role of inducible nitric oxide synthase in the host response to coxsackievirus myocarditis. Proc Natl Acad Sci USA 1998, 95:2469-2474.
37. 37. Barbaro G, Di Lorenzo G, Soldini M et al. The intensity of myocardial expression of inducible nitric oxide synthase influences the clinical course of human immunodeficiency virus-associated cardiomyopathy. Circulation 1999, 100:633-639.
38. 38. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992, 257:387-389.
39. 39. Yokohama T, Vaca L, Rossen RD, Durante W, Hazarika P, Mann DL. Cellular basis for the negative inotropic effect of tumor necrosis factor-alpha in the adult mammalian heart. J Clin Invest 1993, 92:2303-2312.
40. 40. Ungureanu-Longrois D, Balligand JL et al. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ Res 1995, 77:494-502.
41. 41. Meldrum DR. Tumor necrosis factor in the heart. Am J Physiol 1998, 274:577-595.
42. 42. Philippon V. The basic domain of the lentivirus protein is responsible for damage in mouse brain: involvement of cytokines. Virology 1994, 205:519-529.
43. 43. Yeung MC, Pulliam L, Lau A. The HIV envelope protein gp120 is toxic to human brain culture through the induction of interleukin-6 and tumor necrosis factor-α. AIDS 1995, 9:137-143.
44. 44. Bukrinsky MI, Nottet HS, Schmidtmayerova H et al. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J Exp Med 1995, 181:735-745.
45. 45. Fiala M, Rhodes RH, Shapshak P, et al. Regulation of HIV-1 infection in astrocytes: expression of Nef, TNF-alpha and IL-6 in enhanced coculture of astrocytes with macrophages. J Neurovirol 1996, 2:158-166.
46. 46. Rostasy K, Monti L, Yiannoutsos C et al. Human immunodeficiency virus infection, inducible nitric oxide synthase expression and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex. Ann Neurol 1999, 46:207-216.
47. 47. Merrill JE, Murphy SP, Mitrovic B et al. Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J Neurosci Res 1997, 48:372-384.
48. 48. Adamson DC, Mc Arthur JC, Dawson TM, Dawson VL. Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS. Mol Med 1999, 5:98-109.
49. 49. Schrager LK, D'Souza MP. Cellular and anatomical reservoirs of HIV-1 in patients receiving potent antiretroviral combination therapy. J Am Med Assoc 1998, 280:67-71.
50. 50. Ghanekar S, Zheng L, Logar A et al.Cytokine expression by human peripheral blood dendritic cells stimulated in vitro with HIV-1 and herpes simplex virus. J Immunol 1996, 157: 4028-4036.
51. 51. Barbaro G. Dilated cardiomyopathy in the acquired immunodeficiency syndrome. [Editorial] Eur Heart J 1999, 20:629-630.