Local anaesthetic effect of topical amethocaine gel in neonates: Randomised controlled trial

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 82, Issue 1, 2000, Pages

  Jain, Anoo ^a   Rutter, Nicholas ^a  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

Amethocaine gel; Anaesthesia; Pain

Indexed keywords

TETRACAINE;

ANALGESIA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN INTENSIVE CARE; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WITHDRAWAL REFLEX;

EID: 0034067025     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/fn.82.1.F42     Document Type: Article

References (24)

1. 1 Barker DP, Rutter N. Exposure to invasive procedures in neonatal intensive care unit admissions. Arch Dis Child Fetal Neonatal Ed 1995;72:F47-8.
2. 2 Harpin VA, Rutter N. Making heel pricks less painful. Arch Dis Child 1983;58:226-8.
3. 3 Barker DP, Rutter N. Lignocaine ointment and local anaesthesia in preterm infants. Arch Dis Child Fetal Neonatal Ed 1995;72:F203-4.
4. 4 Rushforth JA, Griffiths G, Thorpe H, Levene MI. Can topical lignocaine reduce behavioural response to heel prick? Arch Dis Child Fetal Neonatal Ed 1995;72:F49-51.
5. 5 Larsson BA, Jylli L, Lagercrantz H, Olsson GL. Does a local anaesthetic cream (EMLA) alleviate pain from heel-lancing in neonates? Acta Anaesthesiologica Scandinavica 1995;39:1028-31.
6. 6 Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics 1998;101:E1.
7. 7 Acharya AB, Bustani PC, Phillips JD, Taub NA, Beattie RM. Randomised controlled trial of eutectic mixture of local anaesthetics cream for venepuncture in healthy preterm infants. Arch Dis Child Fetal Neonatal Ed 1998;78:F138-42.
8. 8 Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Alleviation of the pain of venepuncture in neonates. Acta Paediatrica Scandinavica 1998;87:774-9.
9. 9 Woolfson AD, McCafferty DF, Boston V. Clinical experiences with a novel percutaneous amethocaine preparation: prevention of pain due to venepuncture in children. Br J Clin Pharmacol 1990;30:273-9.
10. 10 Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Venipuncture is more effective and less painful than heel lancing for blood tests in neonates. Pediatrics 1998;101:882-6.
11. 11 Shah VS, Taddio A, Bennett S, Speidel BD. Neonatal pain response to heel stick vs venepuncture for routine blood sampling. Arch Dis Child Fetal Neonatal Ed 1997;77:F143-4.
12. 12 Brisman M, Ljung BML, Otterbom I, Larsson LE, Andreasson SE. Methaemoglobin formation after the use of EMLA in term neonates. Acta Paediatrica Scandinavica 1998;87:1191-4.
13. 13 Duncan PG, Kobrinsky N. Prilocaine-induced methemoglobinemia in a newborn infant. Anesthesiology 1983;59:75-6.
14. 14 Kumar AR, Dunn K, Naqvi M. Methemoglobinemia associated with a prilocaine-lidocaine cream. Clin Pediatr 1997;36:239-40.
15. 15 Lloyd CJ. Chemically induced methaemoglobinaemia in a neonate. Br J Oral Maxillofacial Surg 1992;30:63-5.
16. 16 McCafferty DF, Woolfson AD, Boston V. In vivo assessment of percutaneous local anaesthetic preparations. Br J Anaesthes 1989;62:17-21.
17. 17 Mazumdar B, Tomlinson AA, Faulder GC. Preliminary study to assay plasma amethocaine concentrations after topical application of a new local anaesthetic cream containing amethocaine. Br J Anaesthes 1991;67:432-6.
18. 18 McCafferty DF, Woolfson AD. Pharmacists 'magic' gel is launched. The Pharmaceutical Journal 1996;256:219.
19. 19 Barker DP, Rutter NR. Skin blood flow and topical local anaesthesia in preterm infants. Early Hum Dev 1996;45:163-4.
20. 20 Andrews K, Fitzgerald M. The cutaneous withdrawal reflex in human neonates: sensitization, receptive fields, and the effects of contralateral stimulation. Pain 1994;56:95-101.
21. 21 Fitzgerald M, Shaw A, MacIntosh N. Postnatal development of the cutaneous flexor reflex: comparative study of preterm infants and newborn rat pups. Dev Med Child Neurol 1988;30:520-6.
22. 22 Woolf CJ, Swett JE. The cutaneous contribution to the hamstring flexor reflex in the rat: an electrophysiological and anatomical study. Brain Res 1984;303:299-312.
23. 23 Doyle E, Freeman J, Im NT, Morton NS. An evaluation of a new self-adhesive patch preparation of amethocaine for topical anaesthesia prior to venous cannulation in children. Anaesthesia 1993;48:1050-2.
24. 24 Lawson RA, Smart NG, Gudgeon AC, Morton NS. Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children. Br J Anaesthes 1995;75:282-5.