Benign monoclonal expansion of CD8+ lymphocytes in HIV infection

Journal of Clinical Pathology

Volumn 53, Issue 3, 2000, Pages 177-181

  Smith, Penelope R ^a   Cavenagh, Jamie D ^a   Milne, Tim ^a   Howe, Denise ^b   Wilkes, Susanna J ^a   Sinnott, Paul ^a   Forster, Greta E ^a   Helbert, Matthew ^a  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

^b MUSGROVE PARK HOSPITAL   (United Kingdom)

Author keywords

CD8+ lymphocytosis; Clonality; HIV infection

Indexed keywords

ANTINUCLEAR ANTIBODY; HLA DR ANTIGEN; IMMUNOGLOBULIN; PARAPROTEIN; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNE RESPONSE; IMMUNOPHENOTYPING; LYMPHOCYTOSIS; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION;

ADULT; ANTIBODIES, MONOCLONAL; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; LYMPHOCYTOSIS; MALE; MIDDLE AGED; RECEPTORS, LYMPHOCYTE HOMING; SYNDROME; T-LYMPHOCYTE SUBSETS;

EID: 0034065082     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.53.3.177     Document Type: Article

References (23)

1. 1 Brugnoni D, Prati E, Cattaneo R, et al. The primary response to HIV infection is characterized by an expansion of activated CD8+ CD28-cells. AIDS 1996;10:104-6.
2. 2 Roos MTL, Lange JMA, De Geode REY, et al. Virus phenotype and immune response in primary human immunodeficiency virus type 1 (HIV-1) infection. J Infect Dis 1992;165:427-32.
3. 3 Livingstone WJ, Moore M, Simmonds P, et al. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Lancet 1996:348:649-54.
4. 4 Itescu S, Bracato LJ, Buxbaum J, et al. A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DR5. Ann Intern Med 1990;112:3-10.
5. 5 Kazi S, Cohen PR, Reveille JD, et al. The diffuse infiltrative lymphocytosis syndrome: clinical and immunogenetic features in 35 patients. AIDS 1996;10:385-91.
6. 6 Moulignier A, Authier FJ, Baudrimont M, et al. Peripheral neuropathy in human immunodeficiency virus-infected patients with the diffuse infiltrative lymphocytosis syndrome. Ann Neurol 1997;41:438-45.
7. 7 Dwyer E, Itescu S, Winchester R. Characterization of the primary structure of T cell receptor β chains in cells infiltrating the salivary gland in the sicca syndrome of HIV-1 infection. J Clin Invest 1993;92:495-502.
8. 8 Itescu S, Rose S, Dwyer E, et al. Certain HLA-DR5 and-DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progression. Proc Natl Acad Sci USA 1994;91:11472-6.
9. 9 Itescu S, Dalton J, Zhang HZ, et al. Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immunodeficiency virus-1 infection has the phenotypic appearance of an antigenically driven response. J Clin Invest 1993;91:2216-25.
10. 10 Halapi E, Gigliotti D, Hodara V, et al. Detection of CD8 T cell expansions with restricted T cell receptor V gene usage in infants vertically infected by HIV-1. AIDS 1996;10: 1621-6.
11. 11 Constans J, Ladner J, Dabis F, et al. Hyperlymphocytose CD8 au cours de l'infection par le VIH:63 observations. Presse Med 1992;21:27-30.
12. 12 Lynas C, Howe D. Simple, reliable detection of T cell clones by PCR-LIS-SSCP analysis of TCRγ rearrangement. Mol Cell Probes 1998;12:41-8.
13. 13 Brinchmann JE, Gaudernack G, Vartdal F. CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. J Immunol 1990;144:2961-6.
14. 14 Alouf JE, Geoffroy C, Montagnier L, et al. High production of the acquired immunodeficiency syndrome virus (lymphadenopathy-associated virus) by human T lymphocytes stimulated by streptococcal mitogenic toxins. J Clin Microbiol 1986;24:639-41.
15. 15 Zambello R, Trentin L, Agostini C, et al. Persistent polyclonal lymphocytosis in human immunodeficiency virus-1 infected patients. Blood 1993;81:3015-21.
16. - clonal large granular lymphocyte leukaemia and HIV infection. Br J Haematol 1997;98:444-5.
17. 17 Schwab R, Szabo P, Manavalan JS, et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 1997;158:4493-9.
18. 18 Nakahara K, Utsunomiya A, Hanada S, et al. Transient appearance of CD3+CD8+ T lymphocytes with monoclonal gene rearrangement of the T cell receptor β locus. Br J Haematol 1998;100:411-14.
19. 19 Strickler JG, Movahed LA, Gajl-Peczalska KJ, et al. Oligoclonal T cell receptor gene rearrangement in blood lymphocytes of patients with acute Epstein-Barr virus-induced infectious mononucleosis. J Clin Invest 1990;86: 1358-63.
20. 20 Pollack H, Zhan M-X, Safrit JT, et al. CD8+ T cell-mediated suppression of HIV replication in the first year of life: association with lower viral load and favorable early survival. AIDS 1997;11:F9-13.
21. 21 Walker CM, Levy JA. A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication. Immunology 1989;66:628-30.
22. 22 Murali-Krishna K, Altman JD, Suresh M, et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 1998;8:177-87.
23. 23 Gray CM, Lawrence J, Schapiro JM, et al. Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol 1999;162:1780-8.