How does Helicobacter pylori infection interact with non-steroidal anti-inflammatory drugs?

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 14, Issue 1, 2000, Pages 161-172

  Chan, Francis K L ^a   Sung, Joseph J Y ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

H. pylori; Non steroidal anti inflammatory drugs; Peptic ulcer

Indexed keywords

ACETYLSALICYLIC ACID; BICARBONATE; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PROSTAGLANDIN; PROTON PUMP INHIBITOR;

ADAPTATION; CLINICAL TRIAL; COHORT ANALYSIS; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; NEUTROPHIL; PATHOGENESIS; REVIEW; RISK FACTOR; STOMACH ACID SECRETION; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCUS; STOMACH ULCER;

EID: 0034064733     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.1999.0066     Document Type: Article

References (83)

1. Heresbach D, Raoul J L, Bretagne J F. Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy. Gut. 33:1992;1608-1611
2. Upadhyay R, Howatson A, McKinlay A. Campylobacter pylori associated gastritis in patients taking non-steroidal anti-inflammatory drugs. British Journal of Rheumatology. 27:1988;113-116
3. Graham D Y, Lidsky M D, Cox A M. Long-term non-steroidal anti-inflammatory drug use and Helicobacter pylori infection. Gastroenterology. 100:1991;1653-1657
4. Martin D F, Montgomery E, Dobek A S. Campylobacter pylori, NSAIDs, and smoking: risk factors for peptic ulcer disease. American Journal of Gastroenterology. 84:1989;1268-1272
5. Shallcross T M, Rathbone B J, Wyatt J I, Heatley R V. Helicobacter pylori associated chronic gastritis and peptic ulceration in patients taking non-steroidal anti-inflammatory drugs. Alimentary Pharmacology and Therapeutics. 4:1990;515-522
6. Loeb D S, Talley N J, Ahlquist D A. Long-term non-steroidal anti-inflammatory drug use and gastroduodenal injury: the role of Helicobacter pylori. Gastroenterology. 102:1992;1899-1905
7. Li E KM, Sung J Y, Suen R. Helicobacter pylori infection increases the risk of peptic ulcers in chronic users of non-steroidal anti-inflammatory drugs. Scandinavian Journal of Rheumatology. 25:1996;42-46
8. Menguy R, Desbaillets L. Role of inhibition of gastric mucous secretion in the phenomenon of gastric mucosal injury by indomethacin. American Journal of Digestive Diseases. 12:1967;862-866
9. Rainsford K D, Whithouse M W. Biochemical gastroprotection from acute ulceration induced by aspirin and related drugs. Biochemical Pharmacology. 29:1980;1281-1289
10. Sarosiek J, Mizuta K, Slomiany B. Effect of acetylsalicylic acid on gastric mucin activity, permeability to hydrogen ion, and susceptibility to pepsin. Biochemical Pharmacology. 35:1986;4291-4295
11. Wallace J L, McKnight G W. The mucoid cap over superficial gastric damage in the rat. Gastroenterology. 99:1990;295-304
12. Sarosiek J, Slomiany A, Slomiany B L. Evidence for weakening of gastric mucus integrity by Campylobacter pylori. Scandinavian Journal of Gastroenterology. 23:1988;585-590
13. Mersereau W A, Hinchey E J. Effect of gastric acidity on gastric ulceration induced by haemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology. 64:1973;1130-1135
14. Richtie W P, Shearburn E W. Influence of isoproterenol and cholestyramine on acute mucosal ulcerogenesis. Gastroenterology. 73:1977;62-65
15. Gerkens J F, Shand D G, Flexner A. Effect of indomethacin and aspirin on gastric blood flow and acid secretion. Journal of Pharmacology and Experimental Therapeutics. 203:1977;246-252
16. Gana T J, MacPherson B R, Koo J. Gastric mucosal blood flow in misoprostol pretreated aspirin-induced ulceration. Annals of Surgery. 207:1988;327-334
17. Hirose H, Takeuch K, Okabe S. Effect of indomethacin on gastric blood flow around acetic acid-induced gastric ulcers in rats. Gastroenterology. 100:1991;1259-1265
18. Taha A S, Angerson W, Nakshabendi I. Gastric and duodenal mucosal blood flow in patients receiving non-steroidal anti-inflammatory drugs - influence of age, smoking, ulceration and Helicobacter pylori. Alimentary Pharmacology and Therapeutics. 7:1993;41-45
19. Konturek J W, Dembinski A, Konturek S. Infection of Helicobacter pylori in gastric adaptation to continued administration of aspirin in humans. Gastroenterology. 114:1998;245-255
20. Ashley S W, Sonnenschein L A, Cheung L Y. Focal gastric mucosal blood flow at the site of aspirin-induced ulceration. American Journal of Surgery. 149:1985;53-59
21. Graham D Y, Lacey S J, Spjut H J, Torres E. Gastric adaptation: studies in humans during continuous aspirin administration. Gastroenterology. 95:1988;327-333
22. Konturek J W, Dopinsky A, Stoll R. Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth, and neutrophil activation. Gut. 35:1994;1197-1204
23. Kelly S M, Jenner J R, Dickinson R J, Hunter J O. Increased gastric juice epidermal growth factor after non-steroidal anti-inflammatory drug ingestion. Gut. 35:1994;611-614
24. Polk W H, Dempsey P J, Russell W F. Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology. 102:1992;1467-1474
25. Lipscomb G R, Wallis N, Armstrong G. Influence of Helicobacter pylori on gastric mucosal adaptation to naproxen in man. Digestive Diseases and Sciences. 41:1996;1583-1588
26. Lanza F L, Evans D G, Graham D Y. Effect of Helicobacter pylori infection on the severity of gastroduodenal mucosal injury after the acute administration of naproxen or aspirin to normal volunteers. American Journal of Gastroenterology. 86:1991;735-737
27. Thillainayagam A V, Tabaqchali S, Warrington S J, Farthing M JG. Interrelationships between Helicobacter pylori infection, non-steroidal anti-inflammatory drugs and gastroduodenal disease. A prospective study in healthy volunteers. Digestive Diseases and Sciences. 39:1994;1085-1089
28. Laine L, Cominelli F, Sloane R. Interaction of NSAIDs and Helicobacter pylori on gastroduodenal injury and prostaglandin production: a controlled double-blind trial. Alimentary Pharmacology and Therapeutics. 9:1995;127-135
29. Taha A S, Sturrock R D, Russell R I. Mucosal erosions in longterm non-steroidal anti-inflammatory drug users: predisposition to ulceration and relation toHelicobacter pylori. Gut. 36:1995;334-336
30. Kim J G, Graham D Y. The Misoprostol Study Group. Helicobacter pylori infection and the development of gastric or duodenal ulcer in arthritic patients receiving chronic NSAID therapy. American Journal of Gastroenterology. 89:1994;203-207
31. Lipscomb G R, Campbell F, Rees W D. The influence of age, gender, Helicobacter pylori and smoking on gastric mucosal adaptation to non-steroidal anti-inflammatory drugs. Alimentary Pharmacology and Therapeutics. 11:1997;907-912
32. Chan F KL, Sung J Y, Chung S C. Randomised trial of eradication of Helicobacter pylori before starting non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers. Lancet. 350:1997;975-979
33. Levine R A, Nandi J, King R L. Nonsalicylate non-steroidal anti-inflammatory drugs augment prestimulated acid secretion in rabbit parietal cells. Gastroenterology. 101:1991;756-765
34. Feldman M, Colturic T J. Effect of indomethacin on gastric acid and bicarbonate secretion in humans. Gastroenterology. 87:1984;1339-1343
35. Elliott S L, Ferris R J, Giraud A S. Indomethacin damage to rat gastric mucosa is markedly dependent on luminal pH. Clinical and Experimental Pharmacology and Physiology. 23:1996;432-434
36. Levy K J. Drugs, gastritis and peptic ulcers. Clinical Gastroenterology. 3:1981;29-34
37. El-Omar E, Penman I, Ardill J ES, McColl K EL. A substantial proportion of non-ulcer dyspepsia patients have the same abnormality of acid secretion as duodenal ulcer patients. Gut. 36:1995;534-538
38. Ruiz B, Correa P, Fontham E TH. Antral atrophy, Helicobacter pylori colonization, and gastric pH. American Journal of Clinical Pathology. 105:1996;96-101
39. Griffin M R, Piper J M, Daugherty J R. Nonsteroidal anti-inflammatory drug use and increased risk for peptic ulcer disease in elderly persons. Annals of Internal Medicine. 114:1991;257-263
40. Smalley W E, Ray W A, Daugherty J R. Nonsteroidal anti-inflammatory drugs and the incidence of hospitalization for peptic ulcer disease in elderly persons. American Journal of Epidemiology. 141:1995;539-545
41. Jones S T, Clague R B, Eldridge J, Jones D M. Serological evidence of infection with Helicobacter pylori may predict gastrointestinal intolerance to nonsteroidal antiinflammatory drug (NSAID) treatment in rheumatoid arthritis. British Journal of Rheumatology. 30:1991;16-20
42. Hudson N, Balsitis M, Filipowicz F, Hawkey C J. Effect of Helicobacter pylori colonisation on gastric mucosal eicosanoid synthesis in patients taking non-steroid anti-inflammatory drugs. Gut. 34:1993;748-751
43. Goggin P M, Collins D A, Jazrawi R P. Prevalence of Helicobacter pylori infection and its effects on symptoms and nonsteroidal anti-inflammatory drug-induced gastrointestinal damage in patients with rheumatoid arthritis. Gut. 34:1993;1677-1680
44. Caselli M, Pazzi P, LaCorte R. Campylobacter -like organisms, non-steroidal anti-inflammatory drugs and gastric lesions in patients with rheumatoid arthritis. Digestion. 44:1989;101-104
45. Iglehart I W, Edlow D W, Muills L. The presence of Campylobacter pylori in non-steroidal anti-inflammatory drug associated gastritis. Journal of Rheumatology. 16:1989;599-603
46. Taha A S, Nakshabendi I, Lee F D. Chemical gastritis and Helicobacter pylori related gastritis in patients receiving non-steroidal anti-inflammatory drugs: comparison and correlation with peptic ulceration. Journal of Clinical Pathology. 45:1992;135-139
47. de Witte T J, Geerdink P J, Lamers C B. Hypochlorhydria and hypergastrinaemia in rheumatoid arthritis. Annals of Rheumatic Diseases. 38:1979;14-17
48. Labenz J, Kohl H, Wolters S. Helicobacter pylori, NSAIDs and the risk of peptic ulcer bleeding - a prospective case-control study with matched pairs. Gastroenterology. 110:1996;A165
49. Stack W A, Hawkey G M, Atherton J C. Interaction of risk factors for peptic ulcer bleeding. Gastroenterology. 116:1999;A97
50. Santolaria S, Lanas A, Benito R. Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but is not for bleeding duodenal ulcers in NSAID users. Gastroenterology. 116:1999;A231
51. Chan F KL, Sung J Y, Chung S CS. Helicobacter pylori, NSAIDs, and peptic ulcers. Lancet. 351:1998;61-62
52. Chan F KL, Sung J Y. Helicobacter pylori eradication in long-term users of non-steroidal anti-inflammatory drugs. Lancet. 352:1998;2016-2017
53. Labenz J, Tillenburg B, Peitz U. Helicobacter pylori augments the pH-increasing effect of omeprazole in patients with duodenal ulcer. Gastroenterology. 110:1996;725-732
54. Gillen D, Wirz A A, Neithercut W D. Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. Gut. 44:1999;468-475
55. Hawkey C J, Karrasch J A, Szczepanski L. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal anti-inflammatory drugs. New England Journal of Medicine. 338:1998;727-734
56. Yeomans N D, Tulassay Z, Juhasz L. Omeprazole compared with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. New England Journal of Medicine. 338:1998;719-726
57. Hawkey C J, Tulassay Z, Szczepanski L. Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study. Lancet. 352:1998;1016-1021
58. Chan F KL, Sung J Y, Suen R. Does eradication of H. pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study. Alimentary Pharmacology and Therapeutics. 12:1998;1201-1205
59. Redfern J S, Lee E, Feldman M. Effects of indomethacin on gastric mucosal prostaglandins in humans. Correlation with mucosal damage. Gastroenterology. 92:1987;969-977
60. Ligumsky M, Golanska E M, Kauffman D L. Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat. Gastroenterology. 84:1983;756-761
61. Asako H, Kubes P, Wallace J L. Modulation of leukocyte adhesion to rat mesenteric venules by aspirin and salicylate. Gastroenterology. 103:1992;146-152
62. Andrews F J, Malcontenti-Wilson C, O'Brien P E. Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. American Journal of Physiology. 266:1994;G657-G664
63. Laine L, Cominelli F, Sloane R. Interaction of NSAIDs and Helicobacter pylori on gastroduodenal injury and prostaglandin production: a controlled double-blind trial. Alimentary Pharmacology and Therapeutics. 9:1995;127-135
64. To K F, Chan F KL, Leung W K, Sung J Y. Expression of cyclooxygenase 1 (COX-1) and 2 (COX-2) in H. pylori associated gastritis. Gastroenterology. 114:1998;A310
65. Hudson N, Balsitis M, Filipowicz F, Hawkey C J. Effect of Helicobacter pylori colonisation on gastric eicosanoid synthesis in patients taking non-steroidal anti-inflammatory drugs. Gut. 34:1993;748-751
66. McCafferty D M, Granger D N, Wallace J L. Indomethacin-induced gastric injury and leukocyte adherence in arthritic versus healthy rats. Gastroenterology. 109:1995;1173-1180
67. Wallace J L. Nonsteroidal anti-inflammatory drugs and gastropathy: the second hundred years. Gastroenterology. 112:1997;1000-1016
68. Vaananen P M, Meddings J B, Wallace J L. Role of oxygen-derived free radicals in indomethacin-induced gastric injury. American Journal of Physiology. 261:1991;G470-G475
69. Kitahora T, Guth P H. Effect of aspirin plus hydrochloric acid on the gastric mucosal microcirculation. Gastroenterology. 93:1987;810-817
70. Wallace J L, Keenan C M, Granger D N. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. American Journal of Physiology. 259:1990;G462-G467
71. Lee M, Lee A K, Feldman M. Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats. American Journal of Physiology. 263:1992;G920-G926
72. Crabtree J E, Wyatt J I, Trejdoswicz L K. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. Journal of Clinical Pathology. 47:1994;61-66
73. Zhang Q B, Dawodu J B, Husain A. Association of antral mucosal levels of interleukin 8 and reactive oxygen radicals in patients infected withHelicobacter pylori. Clinical Science. 92:1997;69-73
74. Baggiolini M, Walz A, Kunkel L. Neutrophil-activating-peptide-I/interleukin-8, a novel cytokine that activates neutrophils. Journal of Clinical Investigation. 84:1989;1045-1049
75. Willems J, Joniau S, Cinque S, van Damme J. Human granulocyte chemotactic peptide (IL-8) as a specific neutrophil degranulator: comparison with other monokines. Immunology. 67:1989;540-542
76. Craig P M, Territo M C, Karnes W E, Walsh J H. Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut. 33:1992;1020-1023
77. Taha A S, Danhill S, Morran C. Neutrophils, Helicobacter pylori, and nonsteroidal anti-inflammatory drug users. Gastroenterology. 116:1999;1-7
78. Huang J Q, Lad R J, Sridhar S. H. pylori infection increases the risk of non-steroidal anti-inflammatory drug (NSAID)-induced gastroduodenal ulceration. Gastroenterology. 116:1999;A192
79. Ekstrom P, Carling L, Wetterhus S. Prevention of peptic ulcer and dyspeptic symptoms with omeprazole in patients receiving continuous non-steroidal anti-inflammatory drug therapy. A Nordic Multicentre Study. Scandinavian Journal of Gastroenterology. 31:1996;753-758
80. Bianchi Porro G, Parente F, Imbesi V. Role of Helicobacter pylori in ulcer healing and recurrence of gastric and duodenal ulcers in longterm NSAID users. Response to omeprazole dual therapy. Gut. 59:1996;22-26
81. Chan F KL, Sung J Y, Suen R. Eradication of H. pylori versus maintenance acid suppression to prevent recurrent ulcer haemorrhage in high-risk NSAID users: a prospective randomized study. Gastroenterology. 114:1998;A87
82. Ko C W. Cost-effectiveness of preventing NSAID-induced ulcers. Gastroenterology. 116:1999;A71
83. Hawkey G M, Stack W A, Pearson G. Non-steroidal anti-inflammatory drugs, aspirin and Helicobacter pylori as risk factors for bleeding peptic ulcers. Gut. 41:1997;A5