Prevention of peptic ulcer and dyspeptic symptoms with omeprazole in patients receiving continuous non-steroidal anti-inflammatory drug therapy. A nordic multicentre study

Scandinavian Journal of Gastroenterology

Volumn 31, Issue 8, 1996, Pages 753-758

  Ekstrom P ^a   Carling, L ^b   Wetterhus, S ^b   Wingren, P E ^b   Anker Hansen, O ^b   Lundegardh G ^b   Thorhallsson, E ^b   Unge, P ^b  

^a Sandvikens Hospital   (Sweden)

^b NONE

Author keywords

Arthritis; Dyspeptic symptoms; Erosions; Non steroidal anti inflammatory drugs; Omeprazole; Peptic ulcer; Placebo; Prophylaxis

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; PLACEBO;

ADULT; AGED; ARTHRITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSPEPSIA; FEMALE; HELICOBACTER PYLORI; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OSTEOARTHRITIS; PEPTIC ULCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; RHEUMATOID ARTHRITIS; RISK FACTOR;

EID: 0030016432     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365529609010347     Document Type: Article

References (22)

1. Wolfe F, Kleinheksel SM, Spitz PW, Lubeck DP, Fries JF, Young DY, et al. A multicentre study of hospitalisation in rheumatoid arthritis. Frequency, medical-surgical admissions and charges. Arthritis Rheum 1986;29:614-9.
2. Hazleman BL. Incidence of gastropathy in destructive arthropathies. Scand J Rheumatol 1989; Suppl 78:1-4.
3. Butt JH. Clinical spectrum of the upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs. Natural history, symptomatology and significance. Am J Med 1988; 84 Suppl 2A:5-14.
4. Larkai EN, Smith JL, Lidsky MD, Sessoms SL, Graham DY. Dyspepsia in NSAID users: the size of the problem. J Clin Gastroenterol 1989;11:158-62.
5. McCarthy DM. Non-steroidal anti-inflammatory drug-induced ulcers: management by traditional therapies. Gastroenterology 1989;96:662-74.
6. Hawkey CJ. Non-steroidal anti-inflammatory drugs and peptic ulcers. BMJ 1990;300:278-84.
7. Myerson RM. NSAID-associated gastroduodenal damage. J Pharm Med 1992;2:277-84.
8. Battistini B, Botting R, Bakhle YS. COX-1 and COX-2: toward the development of more selective NSAIDs. Drugs News Persp 1994;7:501-12.
9. Ehsanullah RSB, Page MC, Tildesley G, Wood JR. Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. BMJ 1988; 297:1017-20.
10. Verdickt W, Moran C, Hantschel H, Fraga AM, Stead H, Geis GS. A double blind comparison of the gastroduodenal safety and efficacy of diclofenac and a fixed dose combination of diclofenac and misoprostol in the treatment of rheumatoid arthritis. Scand J Rheumatol 1992;21:85-91.
11. Graham DY, Agrawal NM, Roth SH. Prevention of NSAID-induced gastric ulcer with misoprostol: multicentre, double-blind, placebo-controlled trial. Lancet 1988;2:1277-80.
12. McCarthy DM. NSAID-induced gastrointestinal damage. J Clin Gastroenterol 1990;12 Suppl 2:S13-20.
13. 2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis. Eur J Gastroenterol Hepatol 1995;7:467-75.
14. Walan A, Bader J-P, Classen M, Lamers CBHW, Piper DW, Rutgersson K, et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989;320:69-75.
15. Lauritsen K, Rutgersson K, Bolling E, Brunner G, Eriksson S, Frison L, et al. Omeprazole 20 or 40 mg daily for healing of duodenal ulcer? A double-blind comparative study. Eur J Gastroenterol Hepatol 1992;4:995-1000.
16. Daneshmend TK, Stein AG, Bhaskar NK, Hawkey CJ. Abolition by omeprazole of aspirin induced gastric mucosal injury in man. Gut 1990;31:514-7.
17. Scheiman JM, Behler EM, Loeffler KM, Elta GH. Omeprazole ameliorates aspirin-induced gastroduodenal injury. Dig Dis Sci 1994;39:97-103.
18. Oddson E, Gudjonsson H, Thjodleifsson B. Comparison between ranitidine and omeprazole for protection against gastroduodenal damage caused by naproxen. Scand J Gastroenterol 1992;27:1045-8.
19. French PC, Darekar BS, Mills JG, Wood JR. Ranitidine in the prevention of non-steroidal anti-inflammatory drug-associated gastric and duodenal ulceration in arthritic patients. Eur J Gastroenterol Hepatol 1994;6:1141-7.
20. Lanza FL, Graham DY, Davis RE, Rack MF. Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury. Dig Dis Sci 1990;35:1494-9.
21. Ivey KJ, Paone DB, Krause WJ. Acute effect of systemic aspirin on gastric mucosa in man. Dig Dis Sci 1980;25:97-9.
22. Graham DY, Smith JL, Dobbs SM. Gastric adaptation occurs with aspirin administration in man. Dig Dis Sci 1983;28:1-6.