Synovial fluid glycosaminoglycan concentration does not correlate with severity of chondropathy or predict progression of osteoarthritis in a canine cruciate deficiency model

Journal of Rheumatology

Volumn 27, Issue 3, 2000, Pages 753-763

  Myers, Stephen L ^a   Brandt, Kenneth D ^a   Albrecht, Marjorie E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Animal model; Biochemical markers; Chondropathy; Glycosaminoglycan; Osteoarthritis; Synovial fluid

Indexed keywords

GLYCOSAMINOGLYCAN;

ANIMAL EXPERIMENT; ARTICLE; CHONDROPATHY; CORRELATION FUNCTION; DISEASE SEVERITY; DOG; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; SYNOVIAL FLUID LEVEL;

ANIMALS; ARTHROSCOPY; CARTILAGE, ARTICULAR; DISEASE PROGRESSION; DOGS; FORECASTING; GLYCOSAMINOGLYCANS; HALF-LIFE; LEUKOCYTE COUNT; OSMOLAR CONCENTRATION; OSTEOARTHRITIS, KNEE; PROTEOGLYCANS; SERUM ALBUMIN; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; SYNOVIAL MEMBRANE;

EID: 0034057440     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Bullough PG. The pathogenesis of osteoarthritis. In: Moskowitz RW, Howell DS, Goldberg VM, Mankin HJ, editors. Osteoarthritis: diagnosis and medical/surgical management. Philadelphia: Saunders; 1992:36-9.
2. Brandt KD. Toward pharmacologic modification of joint damage in osteoarthritis. Ann Intern Med 1995;122:874-5.
3. Lequesne M, Brandt KD, Bellamy N, et al. Guidelines for testing slow acting and disease modifying drugs in osteoarthritis. J Rheumatol 1994;Suppl 41:65-71.
4. Mazzuca S, Brandt KD, Katz BP. Is conventional radiography suitable for evaluation of a disease-modifying drug in patients with knee OA? Osteoarthritis Cart 1997;5:217-26.
5. Ayral X, Dougados M, Listrat V, Bonvarlet J-P, Simonnet J, Amor B. Arthroscopic evaluation of chondropathy in osteoarthritis of the knee. J Rheumatol 1996;23:698-706.
6. Myers SL, Dines K, Brandt DA, Brandt KD, Albrecht ME. Experimental assessment by high frequency ultrasound of articular cartilage thickness and OA changes. J Rheumatol 1995;22:109-16.
7. Peterfy CG. Magnetic resonance imaging. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. Oxford: Oxford University Press; 1998:473-94.
8. Thonar EG-MA, Shinmei M, Lohmander LS. Body fluid markers of cartilage changes in osteoarthritis. Rheum Dis Clin North Am 1993;19:635-57.
9. Campion GV, McCrae F, Schnitzer TJ, Lenz ME, Dieppe PA, Thonar EJ. Levels of keratan sulfate in the serum and synovial fluid of patients with osteoarthritis of the knee. Arthritis Rheum 1991;34:1254-9.
10. Lohmander LS. Articular cartilage and osteoarthritis. The role of molecular markers to monitor breakdown, repair and disease. J Anat 1994;184:477-92.
11. Sharif M, George E, Dieppe PA. Correlations between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee. Arthritis Rheum 1995;38:78-81.
12. Attencia LJ, McDevitt CA, Nile WB, Sokoloff L. Cartilage content of an immature dog. Connect Tissue Res 1989;18:235-42.
13. Simkin PA, Bassett JE. Cartilage matrix molecules in serum and synovial fluid. Curr Opin Rheumatol 1995;7:346-51.
14. Brandt KD. A pessimistic view of serologic "markers" for diagnosis and management of osteoarthritis. Biochemical, immunological and clinicopathological perspectives. J Rheumatol 1989;16:39-42.
15. Lohmander LS, Hoerrner LA, Dahlberg L, Roos H, Bjornsson S, Lark MW. Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis. Arthritis Rheum 1994;36:181-9.
16. Ratcliffe A, Shurety W, Caterson B. The quantitation of a native chondroitin sulphate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy. Arthritis Rheum 1993;36:543-50.
17. Saxne T, Heinegard D. Synovial fluid analysis of two groups of proteoglycan epitopes distinguishes early and late cartilage lesions. Arthritis Rheum 1992;35:385-90.
18. Dahlberg L, Ryd L, Heinegard D, Lohmander LS. Proteoglycan fragments in joint fluid: influence of arthrosis and inflammation. Acta Orthop Scand 1992;63:417-23.
19. Saxne T, Heinegard D, Wolheim FA, Pettersson H. Difference in cartilage proteoglycan level in synovial fluid in early rheumatoid arthritis and reactive arthritis. Lancet 1985;2:127-8.
20. Shinmei M, Inamori Y, Yoshihara Y, Kikuchi T, Hayakawa T. The potential for cartilage markers in joint fluid for drug evaluation. In: Kuettner K, Schleyerbach R, Peyron JG, Hascall VC, editors. Articular cartilage and osteoarthritis. New York: Raven Press; 1992:597-609.
21. Poole AR, Rizkalla G, lonescu M, Rosenberg LC, Bogoch E. Increased content of the c-propeptide of type II collagen in OA human cartilage [abstract]. Trans Orthop Res Soc 1991;16:343.
22. Ratcliffe A, Seibel MJ. Biochemical markers of osteoarthritis. Curr Opin Rheumatol 1990;2:770-6.
23. Saxne T, Zunino L, Heinegard D. Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis. Arthritis Rheum 1995;38:82-90.
24. Lohmander LS, Saxne T, Heinegard DK. Release of cartilage oligomeric matrix protein into joint fluid after knee injury and in osteoarthritis. Ann Rheum Dis 1994;53:8-13.
25. Fife RS, Brandt KD, Braunstein EM, et al. The presence of CMGP in serum determined by immunolocation analysis is not a sensitive indicator of "early" OA of the knee. J Lab Clin Med 1991; 117:332-8.
26. Lohmander LS, Felson DT. Defining and validating the clinical role of molecular markers in osteoarthritis. In: Brandt KD, Doherty M, Lohmander LS, editors. Osteoarthritis. Oxford: Oxford University Press; 1998:519-30.
27. Dieppe P. Osteoarthritis and molecular markers (a rheumatologist's perspective). Acta Orthop Scand 1995;266 Suppl: 1-5.
28. Ratcliffe A, Billingham ME, Saed-Nejad F, Muir H, Hardingham TE. Increased release of matrix components from articular cartilage in experimental canine osteoarthritis. J Orthop Res 1992;10:350-8.
29. Levick JR. Synovial fluid: determinants of volume turnover and material concentration. In: Kuettner K, Schleyerbach R, Peyron JG, Hascall VC, editors. Articular cartilage and osteoarthritis. New York: Raven; 1992:529-41.
30. Levick JR. The "clearance" of macromolecular substances such as cartilage markers from synovial fluid and serum. In: Maraudas A, Kuettner K, editors. Methods in cartilage research. San Diego: Academic Press; 1990:352-62.
31. Myers SL, Brandt KD, Eilam O. Even low-grade synovitis significantly accelerates the clearance of protein from the canine knee. Implications for measurement of synovial fluid "markers" of osteoarthritis. Arthritis Rheum 1995;38:1085-91.
32. Wallis WJ, Simkin PA, Nelp WB. Protein traffic in human synovial effusions. Arthritis Rheum 1987;30:57-63.
33. Lollini L, Haller J, Eugui E, et al. Effect of RS-130830, a collagenase-3 selective inhibitor, on a rabbit model of osteoarthritis [abstract]. Arthritis Rheum 1997;40 Suppl:587.
34. Simkin PA, Benedict RS. Iodide and albumin kinetics in normal canine wrists and knees. Arthritis Rheum 1990;33:73-9.
35. Myers SL, O'Connor BL, Brandt KD. Accelerated clearance of albumin from the osteoarthritic knee: implications for interpretation of concentrations of "cartilage markers" in synovial fluid. J Rheumatol 1996;23:1744-8.
36. Myers SL, Brandt KD, O'Connor BL, Visco DM, Albrecht ME. Synovitis and osteoarthritic changes in canine articular cartilage after cruciate ligament transection. Arthritis Rheum 1990; 33:1406-15.
37. Mankin HJ, Dorfman H, Lipiello Z, Zairns A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg 1997;53A:523-37.
38. Farnsdale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulfated glycosaminoglycans with use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-7.
39. Mohamed A, Myers S, Brandt K. Clearance of non-aggregating proteoglycan monomers from the normal knee is comparable to clearance of albumin [abstract]. Arthritis Rheum 1997;40:S184.
40. Kofoed JA, Barcelo AC. Synovial fluid hyaluronic acid in rheumatoid arthritis. Experientia 1979;34:1545-6.
41. Witter J, Roughley PJ, Webber C, Roberts N, Keystone E, Poole AR. The immunologic detection and characterization of cartilage proteoglycan degradation products in synovial fluids of patients with arthritis. Arthritis Rheum 1987;30:519-29.
42. Adams ME, Brandt KD. Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection. J Rheumatol 1991;18:428-35.
43. Brandt KD, Braunstein EM, Visco DM, et al. Cranial (anterior) cruciate ligament transection in the dog: A bona fide model of osteoarthritis, not merely of cartilage injury and repair. J Rheumatol 1991;18:436-46.