Accelerated clearance of albumin from the osteoarthritic knee: Implications for interpretation of concentrations of 'cartilage markers' in synovial fluid

Journal of Rheumatology

Volumn 23, Issue 10, 1996, Pages 1744-1748

  Myers, Stephen L ^a,b   O'Connor, Brian L ^a   Brandt, Kenneth D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

joint fluid; osteoarthritis; synovial clearance; synovitis

Indexed keywords

ALBUMIN I 131;

ANIMAL MODEL; ARTICLE; CLEARANCE; CONTROLLED STUDY; DOG; INTRAARTICULAR DRUG ADMINISTRATION; KNEE OSTEOARTHRITIS; PRIORITY JOURNAL; SYNOVIAL FLUID;

ANIMALS; DOGS; KNEE JOINT; MALE; OSTEOARTHRITIS; SERUM ALBUMIN, RADIO-IODINATED; SYNOVIAL FLUID;

EID: 0029804873     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Lohmander LS: Articular cartilage and osteoarthritis. The role of molecular markers to monitor breakdown, repair and disease. J Anat 1994;84:477-92.
2. Thonar EJ-MA, Shinmei M, Lohmander LS: Body fluid markers of cartilage changes in osteoarthritis. Rheum Dis Clin North Am 1993;19:635-57.
3. Rogachefsky RA, Dean DD, Howell DS, Altman RD: Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. Osteoarthritis Cartilage 1993;1:10.5-14.
4. Buckwalter KA: Imaging in osteoarthritis and crystal deposition disease. Curr Opin Rheumatol 1993;5:503-9.
5. Ratcliffe A, Billingham ME, Saed-Nejad F, Muir H, Hardingham TE: Increased release of matrix components from articular cartilage in experimental canine osteoarthritis. J Orthop Res 1992;10:350-8.
6. Myers SL, Brandt KD, O'Connor BL, Visco DM, Albrecht M: Synovitis and osteoarthritic changes in canine articular cartilage after anterior cruciate ligament transection: Effect of surgical hemostasis. Arthritis Rheum 1990;33:1406-15.
7. Visco DM, Hill MA, Widmer WR, Johnstone B, Myers SL: Experimental osteoarthritis in dogs: A comparison of the Pond-Nuki and medial arthrotomy methods. Osteoarthritis Cartilage 1996;4:23-34.
8. Simkin PA, Bassett JE: Cartilage matrix molecules in serum and synovial fluid. Curr Opinion Rheumatol 1995;7:346-51.
9. Engstrom-Laurem A, Hallgren R: Circulating hyaluronic acid levels vary with physical activity in healthy subjects and in rheumatoid arthritis patients. Arthritis Rheum 1987;30:1333-8.
10. Simkin PA: Synovial perfusion and synovial fluid solutes. Ann Rheum Dis 1995;54:424-8.
11. Myers SL, Brandt KD, Eilam O: Even low-grade synovitis significantly accelerates the clearance of protein from the canine knee. Implications for measurement of synovial fluid "markers" of osteoarthritis. Arthritis Rheum 1995;38:1085-91.
12. Simkin PA, Benedict RS: Iodide and albumin kinetics in normal canine wrists and knees. Arthritis Rheum 1990;33:73-9.
13. Brown TJ, Laurent UBG, Fraser JRE: Turnover of hyaluronan in synovial joints: Elimination of labelled hyaluronan from the knee joint of the rabbit. Exp Physiol 1991;76:125-34.
14. Revell PA, Mayston V, Lalor P, Mapp P: The synovial membrane in osteoarthritis: A histological study including the characterization of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann Rheum Dis 1988;47:300-7.
15. Myers SL, Flusser D, Brandt KD, Heck DA: Prevalence of cartilage shards in synovium and their association with synovitis in patients with early and endstage osteoarthritis. J Rheumatol 1992;19:1247-51.
16. Wallis WJ, Simkin PA, Nelp WB, Foster DM: Intraarticular volume and clearance in human synovial effusions. Arthritis Rheum 1985;28:441-9.
17. O'Connor BL, Visco DM, Heck DA, Myers SL, Brandt KD: Gait alterations in dogs after transection of the anterior cruciate ligament. Arthritis Rheum 1989;32:1142-7.
18. Schumacher HR, Rubinow A, Rothfuss S, Weiser P, Brandt K: Apatite crystal clumps in synovial fluid are an early finding in experimental canine osteoarthritis (abstr). Arthritis Rheum 1994;(suppl)37:S346.
19. Swan A, Chapman B, Heap P, Seward H, Dieppe P: Submicroscopic crystals in osteoarthritic synovial fluids. Ann Rheum Dis 1994;53:467-70.
20. Brandt KD, Thonar EJ-MA: Lack of association between serum keratan sulfate concentrations and cartilage changes of osteoarthritis after transection of the anterior cruciate ligament in the dog. Arthritis Rheum 1989;32:647-51.
21. Shinmei M, Ito K, Matsuyama S, Sakota K: Type II procollagen C-peptide in the joint fluid. Laboratory Examination (Japan) 1991;35:1293-8.
22. Carroll G, McCappin S, Bell M, Schwarzer A, Breidahl P: Comparison of keratan sulfate concentrations and the size distribution of proteoglycans in the synovial fluid of patients with osteoarthritis and pyrophosphate arthropathy. Rheumatol Int 1991;11:63-8.
23. Carroll GJ, Bell MC, Laing BA, McCappin S, Blumer C, Leslie A: Reduction of the concentration and total amount of keratan sulphate in synovial fluid from patients with osteoarthritis during treatment with piroxicam. Ann Rheum Dis 1992;51:850-4.