Elevated serum free fatty acid concentrations inhibit T lymphocyte signaling

FASEB Journal

Volumn 14, Issue 7, 2000, Pages 939-947

  Stulnig, Thomas M ^a   Berger, Markus ^a   Roden, Michael ^a   Stingl, Harald ^a   Raederstorff, Daniel ^b   Waldhäusl, Werner ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antigen receptors; Calcium signaling; Glycosylphosphatidylinositols; Lipids; Signal transduction

Indexed keywords

ARTICLE; CALCIUM SIGNALING; FATTY ACID BLOOD LEVEL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

SIPHONAPTERA (FLEAS);

EID: 0034056783     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.14.7.939     Document Type: Article

References (44)

1. Richieri, G. V., and Kleinfeld, A. M. (1995) Unbound free fatty acid levels in human serum. J. Lipid Res. 36, 229-240
2. Richieri, G. V., and Kleinfeld, A. M. (1989) Free fatty acid perturbation of lransmembrane signaling in cytotoxic T lymphocytes. J. Immunol. 143, 2302-2310
3. Chow, S. C., Ansotegui, I. J., and Jondal, M. (1990) Inhibition of receptor-mediated calcium influx in T cells by unsaturated non-esterified fatty acids. Biochern. J. 267, 727-732
4. Richieri, G. V., and Kleinfeld, A. M. (1990) Free fatty acids inhibit cytotoxic T lymphocyte-mediated lysis of allogencic target cells. J. Immunol. 145, 1074-1077
5. Richieri, G. V., Mescher, M. F., and Kleinfeld, A. M. (1990) Short term exposure to cis unsaturated free fatty acids inhibits degranulation of cytotoxic T lymphocytes. J. Immunol. 144, 671-677
6. Breittmayer, J. P., Pelassy, C., Cousin, J. L., Bernard, A., and Aussel, C. (1993) The inhibition by fatty acids of receptor-mediated calcium movements in Jurkat T-cells is due to increased calcium extrusion. J. Biol. Chem. 268, 20812-20817
7. Reaven, G. M., Hollenbeck, C., Jeng, C. Y., Wu, M. S., and Chen, Y. D. (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37, 1020-1024
8. Brown, R. E., Steele, R. W., Mariner, D. J., Hudson, J. L., and Brewster, M. A. (1983) Fatty acids and the inhibition of mitogen-induced lymphocyte transformation by leukemic serum. J. Immunol. 131, 1011-1016
9. Legaspi, A., Jeevanandam, M., Starnes, H. F., Jr., and Brennan, M. F. (1987) Whole body lipid and energy metabolism in the cancer patient. Metabolism 36, 958-963
10. Hendrickson, S. C., St. Louis, J. D., Lowe, J. E., and Abdel-Aleem, S. (1997) Free fatty acid metabolism during myocardial ischemia and reperfusion. Mol. Cell. Biochem. 166, 85-94
11. Lommi, J., Kupari, M., and Yki-Jarvinen, H. (1998) Free fatty acid kinetics and oxidation in congestive heart failure. Am. J. Cardiol. 81, 45-50
12. Moutschen, M. P., Scheen, A. J., and Lefebvre, P. J. (1992) Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Diabetes Metab. 18, 187-201
13. Levey, D. L., and Srivaslava, P. K. (1996) Alterations in T cells of cancer-bearers: whence specificity? Immunol. Today 17, 365-368
14. Richieri, G. V., Anel, A., and Kleinfeld, A. M. (1993) Interactions of long-chain fatty acids and albumin: determination of free fatty acid levels using the fluorescent probe ADIFAB. Biochemistry 32, 7574-7580
15. Rose, H., Conventz, M., Fischer, Y., Jüngling, E., Hennecke, T., and Kammermeier, H. (1994) Long-chain fatty acid-binding to albumin: re-evaluatiou with directly measured concentrations. Biochim. Biophys. Acta 1215, 321-326
16. Spector, A. A. (1975) Fatty acid binding to plasma albumin. J. Lipid Res. 16, 165-179
17. Abumrad, N. A., Perkins, R. C., Park, J. H., and Park, C. R. (1981) Mechanism of long chain fatty acid permeation in the isolated adipocyte. J. Biol. Chem. 256, 9183-9191
18. Potter, B. J., Sorrentino, D., and Berk, P. D. (1989) Mechanisms of cellular uptake of free fatty acids. Annu. Rev. Nutr. 9, 253-270
19. Bojesen, I. N., and Bojesen, E. (1994) Binding of archidonate and oleate to bovine serum albumin. J. Lipid Res. 35, 770-778
20. Anel, A., Richieri, G. V., and Kleinfeld, A. M. (1993) Membrane partition of fatty acids and inhibition of T-cell function. Biochemistry 32, 530-536
21. Weiss, A., and Littman, D. R. (1994) Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274
22. Stulnig, T. M., Berger, M., Sigmund, T., Stockinger, H., Hořejši, V., and Waldhäusl, W. (1997) Signal transduction via glycosyl phosphatidylinositol-anchored proteins in T cells is inhibited by lowering cellular cholesterol. J. Biol. Chem. 272, 19242-19247
23. 2+ signaling in T-lymphocytes. Crit. Rev. Immunol. 18, 419-448
24. Roden, M., Krssak, M., Stingl, H., Gruber, S., Hofer, A., Fürnsinn, C., Moser, E., and Waldhäusl, W. (1999) Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes 48, 358-364
25. Boden, G., Jadali, F., White, J., Liang, Y., Mozzoli, M., Chen, X., Coleman, E., and Smith, C. (1991) Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J. Clin. Invest. 88, 960-966
26. Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., and Shulman, G. I. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97, 2859-2865
27. Hultin, M., Bengtsson Olivecrona, G., and Olivecrona, T. (1992) Release of lipoprotein lipase to plasma by triacylglycerol emulsions. Comparison to the effect of heparin. Biochim. Biophys. Acta 1125, 97-103
28. Stulnig, T. M., Klocker, H., Harwood, H. J., Jr., Jürgens, G., Schönitzer, D., Jarosch, E., Huber, L. A., Amberger, A., and Wick, G. (1995) In vivo low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase regulation in human lymphocytes and its alterations during aging. Arterioscler. Thromb. Vasc. Biol. 15, 872-878
29. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450
30. Rabinovitch, P. S., June, C. H., Grossmann, A., and Ledbetter, J. A. (1986) Heterogeneity among T cells in intracellular free calcium after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry. J. Immunol. 137, 952-961
31. Raederstorff, D., Meier, C. A., Moser, U., and Walter, P. (1991) Hypothyroidism and thyroxin substitution affect the n-3 fatty acid composition of rat liver mitochondria. Lipids 26, 781-787
32. Steinberg, H. O., Tarshoby, M., Monestel, R., Hook, G., Cronin, J., Johnson, A., Bayazeed, B., and Baron, A. D. (1997) Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J. Clin. Invest. 100, 1230-1239
33. Berridge, M. J. (1993) Inositol trisphosphate and calcium signalling. Nature (London) 361, 315-325
34. 2+ influx by unsaturated fatty acids. Cell Calcium 21, 375-385
35. Schwartz, R. H. (1990) A cell culture model for T lymphocyte clonal anergy. Science 248, 1349-1356
36. Simons, K., and Ikonen, E. (1997) Functional rafts in cell membranes. Nature (London) 387, 569-572
37. Stulnig, T. M., Berger, M., Sigmund, T., Raederstorff, D., Stockinger, H., and Waldhäusl, W. (1998) Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J. Cell Biol. 143, 637-644
38. Reaven, G. M. (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595-1607
39. Miwa, H., Yamamoto, M., Nishida, T., Nunoi, K., and Kikuchi, M. (1987) High-performance liquid chromatographic analysis of serum long-chain fatty acids by direct derivatization method. J. Chromatogr. 416, 237-245
40. (Anonymous). (1994) National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation 89, 1329-1445
41. Hamazaki, T., Nakazawa, R., Tateno, S., Shishido, H., Isoda, K., Hattori, Y., Yoshida, T., Fujita, T., Yano, S., and Kumagai, A. (1984) Effects of fish oil rich in eicosapentaenoic acid on serum lipid in hyperlipidemic hemodialysis patients. Kidney Int. 26, 81-84
42. Herold, P. M., and Kinsella, J. E. (1986) Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. Am. J. Clin. Nutr. 43, 566-598
43. Traill, K. N., and Wick, G. (1984) Lipids and lymphocyte function. Immunol. Today 5, 70-76
44. Chandra, R. K., and Amorin, S. A. D. (1992) Lipids and immunoregulation. Nutr. Res. 12, S137-S145