Facilitatory effects of chronically administered citicoline on learning and memory processes in the dog

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 22, Issue 1, 1998, Pages 115-128

  Bruhwyler, Jacques ^a   Liegeois, Jean Francois ^b   Geczy, Joseph ^a  

^a Therabel Pharma Belgium   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

CDP choline; Citicoline; Dog; Learning; Memory; Operant responding; Retrieval; Temporal regulation

Indexed keywords

ATROPINE; CITICOLINE; ETHYLCHOLINE MUSTARD AZIRIDINIUM; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROX; OXOTREMORINE; PHYSOSTIGMINE; SCOPOLAMINE; UNCLASSIFIED DRUG;

ACETYLCHOLINE BRAIN LEVEL; AGING; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; HEAD INJURY; INSTRUMENTAL CONDITIONING; LEARNING; LEARNING DISORDER; LONG TERM MEMORY; MEMORY; MOTIVATION; NONHUMAN; PARKINSON DISEASE; PSYCHOMOTOR PERFORMANCE; STROKE;

ACOUSTIC STIMULATION; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, OPERANT; CYTIDINE DIPHOSPHATE CHOLINE; DOGS; EXPLORATORY BEHAVIOR; MALE; MEMORY; NOOTROPIC AGENTS; REINFORCEMENT (PSYCHOLOGY); REWARD; TIME FACTORS;

EID: 0031883801     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(97)00183-8     Document Type: Article

References (17)

1. AGUT J. and ORTIZ J.A. (1991) Age-related changes in memory and their pharmacologic modulation, Ann. N.Y. Acad. Sci., 640: 295-297.
2. BRUHWYLER J., CHLEIDE E., GUEUR H. and MERCIER M. (1988) Transformation of a waiting schedule into a temporal regulation schedule (DRRD) by addition of external stimuli in the dog, Behav. Proc., 17: 117-129.
3. BRUHWYLER J. and CHLEIDE E. (1990) Comparative study of the behavioral, neurophysiological, and motor effects of psychotropic drugs in the dog, Biol. Psychiat., 27: 1264-1278.
4. BRUHWYLER J., LIEGEOIS J.F., CHLEIDE E., ROGISTER F., DAMAS J., DELARGE J. and MERCIER M. (1992) Comparative study of typical neuroleptics, clozapine and newly synthesized clozapine-analogues: correlation between neurochemistry and behaviour, Behav. Pharmacol., 3: 567-579.
5. BRUHWYLER J., CHLEIDE E., RETTORI M.C., POIGNANT J.C. and MERCIER M. (1993) Amineptine improves the performance of dogs in a complex temporal regulation schedule, Pharmacol. Biochem. Behav., 45: 897-903.
6. D'ORLANDO K.J. and SANDAGE B.W. (1995) Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury, Neurol. Res., 17: 281-284.
7. DRAGO F., MAUCERI F., NARDO L., VALERIO C., GENAZZANI A.A. and GRASSI M. (1993) Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat, Brain Res. Bull., 31: 485-489.
8. MCGUIRE P.S. and SEIDEN L.S. (1980) Differential effects of imipramine in rats as a function of DRL schedule value, Pharmacol. Biochem. Behav., 13: 691-694.
9. MOLCHAN S.E., MARTINEZ R.A., HILL J.L., WEINTGARNER H.J., THOMPSON K., VITIELLO B. and SUNDERLAND T. (1992) Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model, Brain Res. Rev., 17: 215-226.
10. MORIYAMA T., UEZU K., MATSUMOTO Y., CHUNG S.Y., UEZU E., MIYAGI S., UZA M., MASUDA Y., KOKUBU T., TANAKA T. and YAMAMOTO S. (1996) Effects of dietaryphosphatidylcholine on memory in memory deficient mice with low brain acetylcholine concentration. Life Sci., 58: 111-118.
11. MOSHARROF A.H., PETKOV V.D. and PETKOV V.V. (1987) Effects of meclofenoxate and citicoline on learning and memory in aged rats, Acta Physiologica et Pharmacologica Bulgarica, 13: 17-24.
12. MURAI S., SAITO H., MASUDA Y., ODASHIMA J. and ITOH T. (1995) AF64A disrupts retrieval processes in long-term memory of mice, Neuroreport, 6: 349-352.
13. O'DONNELL J.M. and SEIDEN L.S. (1983) Differential-reinforcement-of-low rate 72-second schedule: Selective effects of antidepressant drugs, J. Pharmacol. Exp. Ther., 224: 80-88.
14. PETKOV V.D., MOSHARROF A.H., KEHAYOV R., PETKOV V.V., KONSTANTINOVA E. and GETOVA D. (1992) Effect of CDP-choline on learning and memory processes in rodents, Methods Find. Exp. Clin. Pharmacol., 14: 593-605.
15. PETKOV V.D., KEHAYOV R.A., MOSHARROF A.H., PETKOV V.V., GETOVA D., LAZAROVA M.B. and VAGLENOVA J. (1993) Effects of cytidine diphosphate choline on rats with memory deficits, Arzneim. Forsch.Drug Res., 43: 822-828.
16. REINER P.B. and FIBIGER H.C. (1995) Functional heterogeneity of central cholinergic systems. In: Psychopharmacology: The Fourth Generation of Progress, F.E. Bloom and D.J. Kupfer (Eds), pp 147-153, Raven Press, New York.
17. WEISS G.B. (1995) Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline, Life Sci., 56: 637-660.