Role for endogenous endothelin in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats

British Journal of Pharmacology

Volumn 129, Issue 5, 2000, Pages 975-983

  Filep, János G ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

Bosentan; Endothelin 1; Endotoxin; ET(A) and ET(B) receptors; FR 139317; Plasma volume; Septic shock; Vascular permeability

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; ALBUMIN; BOSENTAN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENDOTOXIN; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CAPILLARY LEAK SYNDROME; DRUG POTENTIATION; ERYTHROCYTE VOLUME; HEMOCONCENTRATION; HYPOTENSION; KIDNEY; LUNG; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PLASMA VOLUME; PRIORITY JOURNAL; RAT; SEPTIC SHOCK;

EID: 0034052271     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703114     Document Type: Article

References (44)

1. Arai, H., Hori, S., Aramori, I., Ohkubo, H. & Nakanishi, S. (1990). Cloning and expression of a cDNA encoding an endothelin receptor. Nature, 348, 731-732.
2. Baranyi, L., Campbell, W., Ohshima, K., Fujimoto, S., Boros, M. & Okada, H. (1995). The antisense homology box: a new motif within proteins that encodes biologically active peptides. Nature Med., 1, 894-901.
3. Bone, R.C. (1991). The pathogenesis of sepsis. Ann. Intern. Med., 115, 457-469.
4. Clozel, M., Breu, V., Gray, G.A., Kalina, B., Löffler, B.M., Burri, K., Cassal, J.M., Hirth, G., Müller, M., Neidhart, W. & Ramuz, H. (1994). Pharmacological characterization of bosentan, a new potent orally active non-peptide endothelin receptor antagonist. J. Pharmacol. Exp. Ther., 270, 228-235.
5. Ehrenreich, H., Anderson, R.W., Fox, C.H., Rickmann, P., Hoffman, G.S., Travis, W.D., Coligan, J.E., Kehrl, J.H. & Fauci, A.S. (1990). Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J. Exp. Med., 172, 1741-1748.
6. Filep, J.G. (1997). Endogenous endothelin modulates blood pressure, plasma volume and albumin escape after systemic nitric oxide blockade. Hypertension, 30, 22-28.
7. Filep, J.G., Bodolay, E., Sipka, S. Gyimesi, F., Csipö, I. & Szegedi, G. (1995). Plasma endothelin correlates with anti-endothelial antibodies in patients with mixed connective tissue disease. Circulation, 92, 2969-2974.
8. Filep, J.G., Clozel, M., Fournier, A. & Földes-Filep, E. (1994). Characterization of receptors mediating vascular responses to endothelin-1 in the conscious rats. Br. J. Pharmacol., 113, 845-852.
9. Filep, J.G., Delalandre, A. & Beauchamp, M. ( 1997). Dual role for nitric oxide in the regulation of plasma volume and albumin escape during endotoxin shock in conscious rats. Circ. Res., 81, 840-847.
10. Filep, J.G., Földes-Filep, E. & Sirois, P. (1993). Nitric oxide modulates vascular permeability in the rat coronary circulation. Br. J. Pharmacol., 108, 323-326.
11. Filep, J.G., Sirois, M.G., Rousseau, A., Fournier, A. & Sirois, P. (1991). Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor. Br. J. Pharmacol., 104, 797-804.
12. B-receptor antagonist, on regional haemodynamic responses to endothelins in conscious rats. Br. J. Pharmacol., 112, 823-830.
13. Gardiner, S.M., Kemp, P.A., March, J.E. & Bennett, T. (1995). Enhancement of the hypotensive and vasodilator effects of endotoxemia in conscious rats by the endothelin antagonist, SB 209670. Br. J. Pharmacol., 116, 1718-1719.
14. Guo, Y., Cernacek, P., Giaid, A. & Hussain, S.N. (1998). Production of endothelins by the ventillatory muscles in septic shock. Am. J. Respir. Cell. Mol. Biol., 19, 470-476.
15. Hemsen, A., Modin, A. & Weitzberg, E. (1996). Increased concentrations of endothelin-1 messenger RNA in tissues and endothelin-1 peptide in plasma in septic pigs: modulation by betamethasone. Crit. Care. Med., 24, 1530-1536.
16. Ishida, K., Takeshige, K. & Minakami, S. (1990). Endothelin-1 enhances Superoxide generation of human neutrophils stimulated by the chemotactic peptide N-formyl-methionylleucyl-phenylalanine. Biochem. Biophys. Res. Commun., 173,496-500.
17. Kaw, S., Hecker, M. & Vane, J.R. (1992). The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. U.S.A., 89, 6886-6890.
18. Kubes, P. & Granger, D.N. (1992). Nitric oxide modulates microvascular permeability. Am. J. Physiol., 262, H611-H615.
19. Kurose, I., Kubes, P., Wolf, R., Anderson, D.C., Paulson, J., Miyasaka, M. & Granger, D.N. (1993). Inhibition of nitric oxide production: mechanisms of vascular albumin leakage. Circ. Res., 73, 164-171.
20. López-Farré, A., Riesco, A., Espinosa, G., Digiuni, E., Cernadas, M.R., Alvarez, V., Monton, M., Rivas, F., Gallego, M.J., Egido, J., Casado, S. & Caramelo, C. (1993). Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart. Circulation, 88, 1166-1171.
21. Marsden, P.A. & Brenner, B.M. (1992). Transcriptional regulation of the endothelin 1 gene by TNF alpha. Am. J. Physiol., 262, C854-C861.
22. Moncada, S. & Higgs, A. (1993). The L-arginine-nitric oxide pathway. N. Engl. J. Med., 329, 2002-2012.
23. B-like receptors. Biochem. Biophys. Res. Commun., 186, 100-106.
24. Nakamura, T., Kasai, K., Sekiguchi, Y., Banba, N., Takahashi, K., Emoto, T., Hattori, Y. & Shimoda, S. (1991). Elevation of plasma endothelin concentrations during endotoxin shock in dogs. Eur. J. Pharmacol., 205, 277-281.
25. Parillo, J.E. (1993), Pathogenetic mechanisms of septic shock. N, Engl. J. Med., 328, 1471-1477.
26. Pernow, J., Hemsen, A., Hallen, A. & Lundberg, J.M. (1990). Release of endothelin like immunoreactivity in relation to neuropeptide Y and catecholamines during endotoxin shock and asphyxia in the pig. Acta Physiol. Scand., 140, 311-322.
27. Pittet, J.F., Morel, D.R., Hemsen, A., Gunning, K., Lacroix, J.S., Suter, P.M. & Lundberg, J.M. (1991). Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann. Surg., 213, 261-264.
28. Rippe, B., Townsley, M., Thigpen, J., Parker, J.C., Korthuis, R.J. & Taylor, A.E. (1984). Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. Physiol., 57, 233-239.
29. Ruetten, H., Thiemermann, C. & Vane, J.R. (1996). Effects of the endothelin receptor antagoist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rats. Br. J. Pharmacol., 118, 198-204.
30. A antagonist. J. Pharmacol. Exp. Ther., 264, 1040-1046.
31. Sugiura, M., Inagami, T. & Kon, V. (1989). Endotoxin stimulates endothelin-release in vivo and in vitro as demonstrated by radioimmunoassay. Biochem. Biophys. Res. Commun., 161, 1220-1227.
32. Szabó, C., Cuzzocrea, S., Zingarelli, B., O'Connor, M. & Salzman, A. (1997). Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly(ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest., 100, 723-735.
33. Szabó, C., Mitchell, J.A., Thiemermann, C. & Vane, J.R. (1993). Nitric oxide-mediated hyporeactivity to noradrenaline precedes nitric oxide synthase induction in endotoxin shock. Br. J. Pharmacol., 108, 786-792.
34. Takakuwa, T., Endo, S., Nakae, H., Kikichi, M., Suzuki, T., Inada, K. & Yoshida, M. (1994). Plasma levels of TNF-α, endothelin-1 and thrombomodulin in patients with sepsis. Res. Commun. Chem. Pathol. Pharmacol., 84, 261-269.
35. Taylor, A.E. & Granger, D.M. (1984). Exchange of macromolecules accross the microcirculation. In: Renken, E.M. & Michel, C.C. (eds). Handbook of Physiology, Section 2: The Cardiovascular System, Volume IV, Part 1. American Physiological Society: Bethesda, MD. pp. 467-520.
36. Tsukimoto, K., Mathieu-Costello, D., Prediletto, R. & West, J.B. (1990). Structural basis of increased permeability of pulmonary capillaries with high transmural pressures. Am. Rev. Respir. Dis., 141, A297.
37. Vemulapalli, S., Chiu, P.J., Rivelli, M., Foster, C.J. & Sybertz, E.J. (1991). Modulation of circulating endothelin levels in hypertension and endotoxemia in rats. J. Cardiovasc. Pharmacol., 18, 895-903.
38. Voerman, H.J., Stehouwer, C.D., Van Kamp. G.J., Strack Van Schijndel, R.J., Groeneveld, A.B. & Thijs, L.G. (1992). Plasma endothelin levels are increased during septic shock. Crit. Care Med., 20, 1097-1101.
39. Wagner, O.F., Christ, G., Wojta, J., Vierhapper, H., Parzer, S., Nowotny, P.J., Schneider, B., Waldhausl, W. & Binder, B.R. (1992). Polar secretion of endothelin-1 by cultured endothelial cells. J. Biol. Chem., 267, 16066-16068.
40. Weitzberg, E., Lundberg, J.M. & Rudehill, A. (1991 ). Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ. Shock, 33, 222-227.
41. Yamamoto, S., Burman, H.P., O'Donnell, C.P., Cahill, P.A. & Robotham, J.L. (1997). Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock. Am. J. Physiol. (Heart Circ. Physiol.), 272, H1239-1249.
42. Yang, Z.H., Bühler, FR., Diderich, D. & Lüscher, T.F. (1989). Different effects of endothelin-1 on cAMP-and cGMP-mediated vascular relaxation in human arteries and veins. J. Cardiovasc. Pharmatol., 13 (Suppl. 5): S129-S133.
43. Zimmerman, R.S., Martinez, A.J., Maymind, M. & Barbee, R.W. (1992). Effect of endothelin on plasma volume and albumin escape. Circ. Res., 70, 1027-1034.
44. A receptors and platelet-activating factor. Br. J. Pharmacol., 127, 969-979.