Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 4, 1999, Pages 631-642

  Lay, John C ^a   Bennett, William D ^b   Ghio, Andrew J ^b   Bromberg, Philip A ^b   Costa, Daniel L ^b   Kim, Chong S ^b   Koren, Hillel S ^b   Devlin, Robert B ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERRIC OXIDE; INTERLEUKIN 8; IRON; LACTATE DEHYDROGENASE; LEUKOTRIENE C4; LEUKOTRIENE E4; PROSTAGLANDIN E2;

ADULT; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; DRUG EFFECT; DRUG INSTILLATION; FEMALE; HUMAN; INFLAMMATION; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; NEUTROPHIL; PATHOLOGY; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RAT; TIME;

ADULT; ANIMALS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; DINOPROSTONE; FEMALE; FERRIC COMPOUNDS; HUMANS; INFLAMMATION; INSTILLATION, DRUG; INTERLEUKIN-8; IRON; L-LACTATE DEHYDROGENASE; LEUKOTRIENE C4; LEUKOTRIENE E4; LUNG; MACROPHAGES, ALVEOLAR; MALE; NEUTROPHILS; PHAGOCYTOSIS; RATS; TIME FACTORS;

EID: 0033109381     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.4.3355     Document Type: Article

References (61)

1. Schwartz, J., D. Wypij, D. W. Dockcry, J. Ware, S. Zeger, J. D. Spengler, and B. Ferris, Jr. 1991. Daily diaries of respiratory symptoms and air pollution: methodological issues and results. Environ. Health Perspect. 90:181-187.
2. Chestnut, L. G., J. Schwartz, D. A. Savitz, and C. M. Burchfiel. 1991. Pulmonary function and ambient particulate matter: epidemiological evidence from NHANES 1. Arch. Environ. Health 46:135-144.
3. 10 pollution in Utah, Salt Lake, and Cache Valleys. Arch. Environ. Health 46:90-97.
4. Schwartz, J., and A. Marcus. 1990. Mortality and air pollution in London: a time series analysis. Am. J. Epidemiol. 131:185-194.
5. Pope, C. A., III, J. Schwartz, and M. R. Ransom. 1992. Daily mortality and PM10 pollution in Utah Valley. Arch. Environ. Health 47:211-217.
6. Dockery, D. W., C. A. Pope, III, J. D. Spengler, J. H. Ware, M. E. Fay, B. G. Ferris, Jr., and F. E. Speizer. 1993. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 329:1753-1759.
7. Ransom, M. R., and C. A. Pope, III. 1992. Elementary school absences and PM10 pollution in Utah Valley. Environ. Res. 58:204-219.
8. Schwartz, J. 1991. Particulate air pollution and daily mortality in Detroit. Environ. Res. 56:204-213.
9. Utell, M. J., and M. W. Frampton. 1995. Particles and mortality: a clinical perspective. Inhalation Toxicology 7:645-655.
10. Oberdörster, G., J. Ferin, and B. E. Lehnert. 1994. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect. 102:173-179.
11. Anto, J. M., and J. Sunyer. 1990. Epidemiologic studies of asthma epidemics in Barcelona. Chest 90:185s-190s.
12. Schlesinger, R. B., and J. A. Graham. 1992. Health effects of atmospheric acid aerosols: a model problem in inhalation toxicology and air pollution risk assessment. Fundam. Appl. Toxicol. 18:17-24.
13. Diaz-Sanchez, D., A. R. Dotson, H. Takenaka, and A. Saxon. 1994. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J. Clin. Invest. 94:1417-1425.
14. Pritchard, R. J., A. J. Ghio, J. R. Lehman, D. W. Winsett, J. S. Tepper, P. Park, M. I. Gilmour, K. L. Dreher, and D. L. Costa. 1996. Oxidant generation and lung injury after particulate air pollutant exposure increases with the concentrations of associated metals. Inhalation Toxicology 8:457-477.
15. Ghio, A. J., J. Stonehuerner, R. J. Pritchard, C. A. Piantadosi, D. R. Quigley, K. L. Dreher, and D. L. Costa. 1996. Humic-like substances in air pollution particulates correlate with concentrations of transition metals and oxidant generation. Inhalation Toxicology 8:479-494.
16. Dreher, K. L., R. H. Jaskot, J. R. Lehmann, J. H. Richards, J. K. McGee, A. J. Ghio, and D. L. Costa. 1997. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J. Toxicol. Environ. Health 50: 285-305.
17. Jacob, D. J., and E. W. Gottlieb. 1989. Chemistry of a polluted cloudy boundary layer. J. Geophys. Res. 94:12975-13002.
18. Munger, J. W., D. J. Jacob, J. M. Waldman, and M. R. Hoffmann. 1983. Fogwater chemistry in an urban atmosphere. J. Geophys. Res. 88:5109-5121.
19. Lay, J. C., W. D. Bennett, C. S. Kim, R. B. Devlin, and P. A. Bromberg. 1998. Retention and intracellular distribution of instilled iron oxide particles in human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 18:687-695.
20. Stokinger, H. E. 1984. A review of world literature finds iron oxides noncarcinogenic. Am. Ind. Hyg. Assoc. J. 45:127-133.
21. Wilkey, D. D., P. S. Lee, F. J. Hass, T. R. Gerrity, D. B. Yeates, and R. V. Lourenco. 1980. Mucociliary clearance of deposited particles from the human lung: intra- and inter-subject reproducibility, total lung clearance, and model comparisons. Arch. Environ. Health 35:294-303.
22. Ilowite, J. S., G. C. Smaldone, R. J. Perry, W. D. Bennett, and W. M. Foster. 1989. Relationship between tracheobronchial particle clearance rates and sites of initial deposition in man. Arch. Environ. Health 44:267-273.
23. Lourenco, R. V., M. F. Klimek, and C. J. Borowski. 1971. Deposition and clearance of 2μ particles in the tracheobronchial tree of normal subjects -smokers and nonsmokers. J. Clin. Invest. 50:1411-1420.
24. Morrow, P. E., F. R. Gibb, and K. M. Gazioglu. 1967. A study of particulate clearance from the human lungs. Am. Rev. Respir. Dis. 96:1209-1221.
25. Bennett, W. D., W. F. Chapman, J. C. Lay, and T. R. Gerrity. 1993. Pulmonary clearance of inhaled particles 24 to 48 hours post deposition: effect of beta-adrenergic stimulation. J. Aerosol Med. 6:53-62.
26. Wright, J. L., N. Harrison, B. Wiggs, and A. Churg. 1989. Quartz but not iron oxide causes air-flow obstruction, emphysema, and small airways lesions in the rat. Am. Rev. Respir. Dis. 138:129-135.
27. Saffiotti, U., F. Cefis, and L. H. Kolb. 1968. A method for the experimental induction of bronchogenic carcinoma. Cancer Res. 28:104-124.
28. Stenbäck, F., J. Rowland, and A. Sellakumar. 1976. Carcinogenicity of benzo(a)pyrene and dusts in the hamster lung (instilled intratracheally with titanium oxide, aluminum oxide, carbon and ferric oxide). Oncology 33:29-34.
29. Schreiber, H., D. H. Martin, and N. Pazmino. 1975. Species differences in the effect of benzo(a)pyrene-ferric oxide on the respiratory tract of rats and hamsters. Cancer Res. 35:1654-1661.
30. Saffiotti, U., R. Montesano, A. R. Selladumar, F. Cefis, and D. G. Kaufman. 1972. Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. Cancer Res. 32:1073-1081.
31. Neidle, M., and J. Barab. 1917. Studies in dialysis: II. The hot dialysis of the chlorides of ferric iron, chromium, and aluminum, and the rapid preparation of their colloidal hydrous oxides. J. Am. Chem. Doc. 39:71-81.
32. Koren, H. S., R. B. Devlin, D. E. Graham, R. Mann, M. P. McGee, D. H. Horstman, W. J. Kozumbo, S. Becker, D. House, W. F. McDonnell, and P. A. Bromberg. 1989. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 139:407-415.
33. Rennard, S. I., M. Ghafouri, A. B. Thompson, J. Linder, W. Vaughan, K. Jones, R. F. Ertl, K. Christensen, A. Prince, M. Stahl, and R. A. Robbins. 1990. Fractional processing of sequential bronchoalveolar lavage to separate bronchial and alveolar samples. Am. Rev. Respir. Dis. 141:208-217.
34. Pick, E., and Y. Keisari. 1981. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages - induction by multiple nonphagocytic stimuli. Cell Immunol. 59:301-318.
35. Devlin, R. B., W. F. McDonnell, S. Becker, M. C. Madden, M. P. McGee, R. Perez, G. Hatch, D. E. House, and H. S. Koren. 1996. Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hours: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hours after exposure. Toxicol. Appl. Pharmacol. 138:176-185.
36. 4 in pulmonary edema of patients with adult respiratory distress syndrome. J. Clin. Immunol. 4:479-483.
37. Bjerknes, R. 1984. Flow cytometry assay for combined measurement of phagocytosis and intracellular killing of Candida albicans. J. Immunol. Methods 72:229-241.
38. Costa, D. L., J. R. Lehmann, W. M. Harold, and R. T. Drew. 1986. Transoral tracheal intubation of rodents using a fiberoptic laryngoscope. Lab. Anim. Sci. 36:256-261.
39. Stone, K. C., R. R. Mercer, P. Gehr, B. Stockstill, and J. D. Crapo. 1992. Allometric relationships of cell numbers and size in the mammalian lung. Am. J. Respir. Cell Mol. Biol. 6:235-243.
40. Snedecor, G. W., and W. G. Cochran 1967. Statistical Methods. Iowa State University Press, Ames, IA.
41. Lide, David R., editor. 1996. Handbook of Chemistry and Physics. CRC Press, Boca Raton.
42. Morrow, P. E. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. Toxicol. 10:369-384.
43. Lehnert, B. E., Y. E. Valdez, and S. H. Bomalaski. 1985. Lung and pleural "free-cell responses" to the intrapulmonary deposition of particles in the rat. J. Toxicol. Environ. Health 16:823-839.
44. Lindenschmidt, R. C., K. E. Driscoll, M. Perkins, J. Higgins, J. K. Maurer, and K. A. Belfiore. 1990. The comparison of a fibrogenic and two nonfibrogenic dusts by bronchoalveolar lavage. Toxicol. Appl. Pharmacol. 102: 268-281.
45. Oberdörster, G., J. Ferin, R. Gelein, S. C. Soderholm, and J. Finkelstein. 1992. Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ. Health Perspect. 97:193-199.
46. Bowden, D. H., and I. Y. R. Adamson. 1978. Adaptive responses of the pulmonary macrophagic system to carbon: I. Kinetic studies. Lab. Invest. 38:422-429.
47. Kavet, R. I., J. D. Brain, and D. J. Levens. 1978. Characteristics of pulmonary macrophages lavaged from hamsters exposed to iron oxide aerosols. Lab. Invest. 38:312-319.
48. Winterbourn, C. C. 1995. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol. Lett. 82/83:969-974.
49. Schwertmann, U., and R. M. Cornell. 1991. Iron Oxides in the Laboratory. VCH, Weinheim, Germany.
50. Wardman, P., and L. P. Candeias. 1996. Fenton chemistry, an introduction. Radiat. Res. 145:523-531.
51. Goldstein, S., D. Meyerstein, and G. Czapski. 1993. The Fenton reagents. Free Radic. Biol. Med. 15:435-145.
52. White, D. A., M. G. Krfis, and D. E. Stover. 1987. Bronchoalveolar lavage cell populations in bleomycin lung toxicity. Thorax 42:551-552.
53. Hayashi, T., Y. Ueno, and T. Okamato. 1993. Oxidoreductive regulation of nuclear factor κB. J. Biol. Chem. 268:11380-11388.
54. DeForge, L. E., A. M. Preston, E. Takeuchi, J. Kenney, L. A. Boxer, and D. G. Remick. 1993. Regulation of intcrleukin 8 gene expression by oxidant stress. J. Biol. Chem. 268:25568-25576.
55. Simeonova, P. P., and M. I. Luster. 1995. Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-α response from alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 12:676-683.
56. Adamson, I. Y. R., and D. H. Bowden. 1982. Chemotactic and mitogenic components of the alveolar macrophage response to particles and neutrophil chemoattractant. Am. J. Pathol. 109:71-77.
57. Warheit, D. B., L. H. Overby, G. George, and A. R. Brody. 1988. Pulmonary macrophages are attracted to inhaled particles through complement activation. Exp. Lung Res. 14:51-66.
58. Stahlhofen, W., G. Rudolf, and A. C. James. 1989. Intercomparison of experimental regional aerosol deposition data. J. Aerosol Med. 2:285-308.
59. Bennett, W. D., K. L. Zeman, C. Kim, and J. Mascarella. 1997. Enhanced deposition of fine particles in COPD patients spontaneously breathing at rest. Inhalation Toxicology 9:1-14.
60. Isawa, T., K. Wasserman, and B. V. Taplin. 1970. Lung scintigraphy and pulmonary function studies in obstructive disease. Am. Rev. Respir. Dis. 102:161-172.
61. Lin, M. S., and D. A. Goodwin. 1976. Pulmonary distribution of an inhaled radioaerosol in obstructive pulmonary disease. Radiology 118:645-651.