Characterization in cultured cerebellar granule cells and in the developing rat brain of mRNA variants for the NMDA receptor 2C subunit

Journal of Neurochemistry

Volumn 74, Issue 5, 2000, Pages 1798-1808

  Rafiki, Amina ^a   Bernard, Anne ^a   Medina, Igor ^a   Gozlan, Henri ^a   Khrestchatisky, Michel ^a  

^a Turing Center for Living Systems CENTURI Aix Marseille University   (France)

Author keywords

Cerebellum; HEK 293 cells; Hippocampus; In situ hybridization; Introns; RT PCR; Splicing; Transfections

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CEREBELLUM; CONTROLLED STUDY; FOREBRAIN; GENE DELETION; GENE EXPRESSION REGULATION; GENE INSERTION; GENETIC VARIABILITY; GRANULE CELL; HIPPOCAMPUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; RNA SPLICING;

ANIMALIA; EUKARYOTA;

EID: 0034051516     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0741798.x     Document Type: Article

References (39)

1. Akazawa C., Shigemoto R., Bessho Y., Nakanishi S., and Mizuno N. (1994) Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. J. Comp. Neurol. 347, 150-160.
2. Brose N., Gasic G. P., Vetter D. E., Sullivan J. M., and Heinemann S. F. (1993) Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J. Biol. Chem. 268, 22663-22671.
3. Ciabarra A. M., Sullivan J. M, Gahn L. G., Pecht G., Heinemann S., and Sevarino K. A. (1995) Cloning and characterization of chi-l: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J. Neurosci. 15, 6498-6508.
4. Collingridge G. L. and Bliss T. V. (1995) Memories of NMDA receptors and LTP. Trends Neurosci. 18, 54-65.
5. Daggett L. P., Johnson E. C., Varney M. A., Lin F.-F., Hess S. D., Deal C. R., Jachec C., Lu C.-C., Kerner J. A., Landwehrmeyer G. B., Standaert D. G., Young A. B., Harpold M. M., and Veliçelebi G. (1998) The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression. J. Neurochem. 71, 1953-1968.
6. Feldmeyer D. and Cull-Candy S. (1996) Functional consequences of changes in NMDA receptor subunit expression during development. J. Neurocytol. 25, 857-867.
7. 2+ dependent in primary cultures of hippocampal neurons. J. Neurochem. 61, 1105-1112.
8. A receptor subunits revealed by antigen-retrieval immunohistochemistry. J. Comp. Neurol. 390, 194-210.
9. Gray A. T., Leonoudakis D. J., and Yost C. S. (1997) An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc. Brain Res. Mol. Brain Res. 52, 157-161.
10. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
11. Hollmann M. and Heinemann S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
12. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., et al. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843.
13. Kadotani H., Hirano T., Masugi M., Nakamura K., Nakao K., Katsuki M., and Nakanishi S. (1996) Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit. J. Neurosci. 16, 7859-7867.
14. Kadotani H., Namura S., Katsuura G., Terashima T., and Kikuchi H. (1998) Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C. Neuroreport 9, 471-475.
15. Komuro H. and Rakic P. (1993) Modulation of neuronal migration by NMDA receptors. Science 260, 95-97.
16. Krupp J. J., Vissel B., Heinemann S. F., and Westbrook G. L. (1996) Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific. Mol. Pharmacol. 50, 1680-1688.
17. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358, 36-41.
18. Laurie D. J. and Seeburg P. H. (1994) Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition. Eur. J. Pharmacol. 268, 335-345.
19. Laurie D. J., Putzke J., Zieglgansberger W., Seeburg P. H., and Tolle T. R. (1995) The distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain. Brain Res. Mol. Brain Res. 32, 94-108.
20. Leeds P., Wood J. M., Lee B. S., and Culbertson M. R. (1992) Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 2165-2177.
21. Marianowski R., Pollard H., Moreau J., Despres G., Ben Ari Y., Tran Ba Huy P., and Romand R. (1995) N-Methyl-D-aspartate receptor subunits NR1 and NR2C are overexpressed in the inferior colliculus of audiogenic mice. Neurosci. Lett. 189, 190-194.
22. Medina I., Filippova N., Charton G., Rougeole S., Ben-Ari Y., Khrestchatisky M., and Bregestovski P. (1995) Calcium-dependent inactivation of heteromeric NMDA receptor-channels expressed in human embryonic kidney cells. J. Physiol. (Lond.) 482, 567-573.
23. 2+ release. Trends Pharmacol. Sci. 16, 356-359.
24. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., and Seeburg P. H. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221.
25. Monyer H., Burnashev N., Laurie D. J., Sakmann B., and Seeburg P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
26. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N., and Nakanishi S. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
27. Ozawa S., Kamiya H., and Tsuzuki K. (1998) Glutamate receptors in the mammalian central nervous system. Prog. Neurobiol. 54, 581-618.
28. Petralia R. S., Wang Y. X., and Wenthold R. J. (1994a) The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J. Neurosci. 14, 6102-6120.
29. Petralia R. S., Yokotani N., and Wenthold R. J. (1994b) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J. Neurosci. 14, 667-696.
30. Pollard H., Khrestchatisky M., Moreau J., and Ben Ari Y. (1993) Transient expression of the NR2C subunit of the NMDA receptor in developing rat brain. Neuroreport 4, 411-414.
31. Pulak R. and Anderson P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev. 7, 1885-1897.
32. Rabacchi S., Bailly Y., Delhaye-Bouchaud N., and Mariani J. (1992) Involvement of the N-methyl D-aspartate (NMDA) receptor in synapse elimination during cerebellar development. Science 256, 1823-1825.
33. Rafiki A., Gozlan H., Ben-Ari Y., Khrestchatisky M., and Medina I. (1997) The calcium-dependent transient inactivation of recombinant NMDA receptor-channel does not involve the high affinity calmodulin binding site of the NR1 subunit. Neurosci. Lett. 223, 137-139.
34. Rafiki A., Ben-Ari Y., Khrestchatisky M., and Represa A. (1998) Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy. Eur. J. Neurosci. 10, 497-507.
35. Small D. L., Poulter M. O., Buchan A. M., and Morley P. (1997) Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices. Neurosci. Lett. 232, 87-90.
36. Sprengel R., Suchanek B., Amico C., Brusa R., Burnashev N., Rozov A., Hvalby O., Jensen V., Paulsen O., Andersen P., Kim J. J., Thompson R. F., Sun W., Webster L. C., Grant S. G., Eilers J., Konnerth A., Li J., McNamara J. O., and Seeburg P. H. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92, 279-289.
37. Suchanek B., Seeburg P. H., and Sprengel R. (1995) Gene structure of the murine N-methyl D-aspartate receptor subunit NR2C. J. Biol. Chem. 270, 41-44.
38. Sucher N. J., Akbarian S., Chi C. L., Lederc C. L., Awobuluyi M., Deitcher D. L., Wu M. K., Yuan J. P., Jones E. G., and Lipton S. A. (1995) Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J. Neurosci. 15, 6509-6520.
39. Sucher N. J., Awobuluyi M., Choi Y. B., and Lipton S. A. (1996) NMDA receptors: from genes to channels. Trends Pharmacol. Sci. 17, 348-355.