An active-site histidine of NR1/2C mediates voltage-independent inhibition by zinc

Molecular Brain Research

Volumn 52, Issue 1, 1997, Pages 157-161

  Gray, Andrew T ^a   Leonoudakis, Dmitri J ^a   Spencer Yost, C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diethylpyrocarbonate; Ion channel; N methyl D aspartate; Voltage clamp; Xenopus oocyte

Indexed keywords

BARIUM; DIETHYL PYROCARBONATE; HISTIDINE; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT; ZINC;

ARTICLE; ELECTRODE; NERVE CELL MEMBRANE POTENTIAL; OOCYTE; PERFUSION; PRIORITY JOURNAL; VOLTAGE CLAMP; XENOPUS;

ANIMALS; BINDING SITES; HISTIDINE; OOCYTES; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; RECEPTORS, N-METHYL-D-ASPARTATE; XENOPUS LAEVIS; ZINC;

EID: 0030729016     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00275-1     Document Type: Article

References (20)

1. 2+ from brain tissue during activity. Nature. 308:1984;734-736.
2. I. Bertini, C. Luchinat, The reaction pathways of zinc enzymes and related biological catalysts. in: I. Bertini, H.B. Gray, S.J. Lippard, J.S. Valentine (Eds.), Bioinorganic Chemistry. University Science Books, Mill Valley, 1994, pp. 37-106.
3. Christine C.W., Choi D.W. Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons. J. Neurosci. 10:1990;108-116.
4. Donnelly J.L., Pallotta B.S. Single-channel currents from diethylpyrocarbonate-modified receptors in cultured rat brain cortical neurons. J. Gen. Physiol. 105:1995;837-859.
5. Howell G.A., Welch M.G., Frederickson C.J. Stimulation-induced uptake and release of zinc in hippocampal slices. Nature. 308:1984;736-738.
6. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., Nakanishi S. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268:1993;2836-2843.
7. Koh J.Y., Suh S.W., Gwag B.J., He Y.Y., Hsu C.Y., Choi D.W. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science. 272:1996;1013-1016.
8. 2+ block in NMDA receptor channels. J. Neurosci. 16:1996;3549-3558.
9. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., Mishina M. Molecular diversity of the NMDA receptor channel. Nature. 358:1992;36-41.
10. Miles E.W. Modification of histidyl residues in proteins by diethylpyrocarbonate. Methods Enzymol. 47:1977;431-442.
11. Monyer H., Burnashev N., Laurie D.J., Sakmann B., Seeburg P.H. Development and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron. 12:1994;529-540.
12. 2+ site of the NMDA receptor channel. Nature. 358:1992;673-675.
13. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N., Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature. 354:1991;31-37.
14. M.W. Quick, and H.A. Lester, Methods for expression of excitability proteins in Xenopus oocytes. in: P.M. Conn (Ed.), Methods in Neuroscience, Vol. 19, Academic Press, San Diego, CA, 1994, pp. 261-279.
15. Smart T.G., Xie X., Krishek B.J. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Prog. Neurobiol. 42:1994;393-441.
16. Sullivan J.M., Traynelis S.F., Chen H.S., Escobar W., Heinemann S.F., Lipton S.A. Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron. 13:1994;929-936.
17. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurons. J. Physiol. (Lond.). 433:1991;727-763.
18. Traynelis S.F., Hartley M., Heinemann S.F. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science. 268:1995;873-876.
19. Williams K. Separating dual effects of zinc at recombinant N-methyl-D-aspartate receptors. Neurosci. Lett. 215:1996;9-12.
20. Woodhull A.M. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:1973;687-708.