A double-blind, randomized study to compare recombinant human follicle stimulating hormone (FSH; Gonal-F®) with highly purified urinary FSH (Metrodin® HP) in women undergoing assisted reproductive techniques including intracytoplasmic sperm injection

Human Reproduction

Volumn 15, Issue 3, 2000, Pages 520-525

  Frydman, R ^a   Howles, C M ^a   Truong, F ^a  

^a NONE

Author keywords

ICSI; IVF; Multiple follicular development; r hFSH; u hFSH HP

Indexed keywords

BUSERELIN; CHORIONIC GONADOTROPIN; FOLLITROPIN; GONADORELIN AGONIST; LEUPRORELIN; NAFARELIN; NAFARELIN ACETATE; PROGESTERONE; RECOMBINANT FOLLITROPIN; TRIPTORELIN; UNCLASSIFIED DRUG; UROFOLLITROPIN;

ADULT; ARTICLE; BIOMEDICAL TECHNOLOGY ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GROWTH STIMULATION; HORMONE DEPENDENCE; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MALE INFERTILITY; MULTICENTER STUDY; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; OVARY HYPERSTIMULATION; PHASE 4 CLINICAL TRIAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECOMBINANT DNA TECHNOLOGY;

FALLOPIA;

EID: 0034051145     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/15.3.520     Document Type: Article

References (25)

1. Albano, C., Smitz, J., Camus, M. et al. (1996) Pregnancy and birth in an in vitro fertilization cycle after controlled ovarian stimulation in a woman with a history of allergic reaction to human menopausal gonadotrophin. Hum. Reprod., 11, 1632-1634.
2. Bergh, C., Howles, C.M., Borg, K. et al. (1997) Recombinant human follicle stimulating hormone (Gonal-F) versus highly purified urinary FSH (Metrodin HP); results of a randomised comparative study in women undergoing assisted reproductive techniques. Hum. Reprod., 12, 2133-2139.
3. Chappel, S., Kelton, C., Nugent, N. (1992) Expression of human gonadotropins by recombinant DNA methods. In Genazzani, A.R and Petraglia, F. (eds), Proceedings of the 3rd World Congress on Gynecological Endocrinology. Parthenon, Carnforth, Lanes, UK, pp. 179-184.
4. Delvigne, A., Dubois, M., Battheu, B. et al. (1993) The ovarian hyperstimulation syndrome in in-vitro fertilization: a Belgian multicentric study. II. Multiple discriminant analysis for risk prediction. Hum. Reprod., 8, 1361-1366.
5. Devroey, P., Tournaye, H., Van Steirteghem, A. et al. (1998) The use of a 100 IU starting dose of recombinant follicle stimulating hormone (Puregon) in in vitro fertilization. Hum. Reprod., 13, 565-566.
6. FIVNAT (1998) French 1VF/ICS1 register.
7. Habu-Heija, A.T., Yates, R.W.S., Barrett, T. et al. (1995) A comparison of two starting doses of human menopausal gonadotrophin for follicle stimulation in unselected patients for in-vitro fertilisation. Hum. Reprod., 10, 801-803.
8. Howles, C.M., Loumaye, E., Giroud, D. and Luyet, G. (1994) Multiple follicular development and ovarian steroidogenesis following subcutaneous administration of a highly purified urinary FSH preparation in pituitary desensitized women undergoing IVF: a multicentre European phase III study. Hum. Reprod., 9, 424-430.
9. Howles, C.M. (1996) Genetic engineering of human FSH (Gonal-F). Hum. Reprod. Update, 2, 172-191.
10. Le Cotonnec, J.Y., Porchet, H., Beltrami, V. and Howles, C.M. (1993) Comparative pharmacokinetics of two urinary human follicle stimulating hormone preparations in healthy female and male volunteers. Hum. Reprod., 8, 1604-1611.
11. Loumaye, E., Campbell, R. and Salat-Baroux, J. (1995) Human follicle-stimulating hormone produced by recombinant DNA technology: a review for clinicians. Hum. Reprod. Update, 1, 188-199.
12. Nijs, M., Geerts, L., Van Roosendaal, E. et al. (1993) Prevention of multiple pregnancies in an in vitro fertilization program. Fertil. Steril., 59, 1245-1250.
13. Olijve, W., De Boer, W., Mulders, J.W.M. and Van Wezenbeek, P.M.G.F. (1996) Molecular biology and biochemistry of human recombinant follicle stimulating hormone (Puregon). Mol. Hum. Reprod., 2, 371-382.
14. Out, H.J., Mannaerts, B.M.J.L., Driessen, S.G.A.J. and Coelingh Bennink, H.J.T. (1995) A prospective, randomised, assessor-blind, multicentre study comparing recombinant and urinary follicle stimulating hormone (Puregon versus Metrodin) in in-vitro fertilization. Hum. Reprod., 10, 2534-2540.
15. Palermo, G., Joris, H., Devroey, P. and Van Steirteghem, A.C. (1992) Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet, 340, 17-18.
16. Palermo, G., Joris, H., Derde, M.P. et al. (1993) Sperm characteristics and outcome of human assisted fertilisation by subzonal insemination and intracytoplasmic sperm injection. Steril. Fertil., 59, 826-835.
17. Recombinant Human FSH Study Group (1995) Clinical assessment of recombinant human follicle stimulating hormone in stimulating ovarian follicular development before in vitro fertilization. Fertil. Steril., 63, 77-86.
18. Redfearn, A., Hughes, E.G., O'Connor, M. and Dolovich, J. (1995) Delayed-type hypersensitivity to human gonadotropin: case report. Fertil. Steril., 64, 855-856.
19. Schenker, J.G. and Weinstein, D. (1978) Ovarian hyperstimulation syndrome: a current survey. Fertil. Steril., 30, 255-268.
20. Staessen, C. Janssenswillen, C., Van Den Abbeel, E. et al. (1993) Avoidance of triple pregnancies by elective transfer of two good quality embryos. Hum. Reprod., 8, 1650-1653.
21. Templeton A. and Morris J.K. (1998) Reducing the risk of multiple births by transfer of 2 embryos after IVF. N. Engl. J. Med., 339, 573-577.
22. Thornton, S.J. (1966) Starting doses in IVF and effects on outcome. Hum. Reprod., 11, Abstr. Book, 104.
23. Van Steirteghem A.C., Lui J., Joris H. et al. (1993) Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles. Hum. Reprod., 8, 1055-1060.
24. Waterstone, J., Parsons, J. and Bolton V. (1991) Elective transfer of two embryos. Lancet, 337, 975-976.
25. Wikland, M., Borg, J., Hamberger, L. and Svalander, P. (1994) Simplification of IVF: minimal monitoring and the use of subcutaneous highly purified FSH administration for ovulation induction. Hum. Reprod., 9, 1430-1436.