Preclinical study of an oral controlled release naltrexone complex in mice

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 6, 2000, Pages 659-663

  Alvarez Fuentes, J ^a,b   Rojas Corrales, M O ^b   Holgado, M A ^a   Caraballo, I ^a   Mico J A ^b   Fernandez Arevalo M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF CÁDIZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EUDRAGIT; MORPHINE; NALTREXONE; OPIATE ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG FORMULATION; DRUG INHIBITION; DRUG RELEASE; DRUG STRUCTURE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OPIATE ADDICTION;

ADMINISTRATION, ORAL; ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG ADMINISTRATION SCHEDULE; MALE; MICE; NALTREXONE; NARCOTIC ANTAGONISTS; SUBSTANCE-RELATED DISORDERS;

EID: 0034048996     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774499     Document Type: Article

References (14)

1. Alvarez-Fuentes, J., Fernández-Arévalo, M., Holgado, M. A., Caraballo, I., Llera, J. M., Rabasco, A. M. (1994a) Morphine polymeric coprecipitates for controlled release: elaboration and characterization. Drug Dev. Ind. Pharm. 20: 2409-2424
2. Alvarez-Fuentes, J., Fernández-Arévalo, M., Holgado, M. A., Caraballo, I., Liera, J. M., Rabasco, A. M. (1994b) Characterization of morphine polymeric coprecipitates. Biopharmaceutical study. Die Pharmazie 49: 834-839
3. Alvarez-Fuentes, J., Fernández-Arévalo, M., Holgado, M. A., Caraballo, I., Rabasco, A. M., Mico, J. A., Rojas, O., Ortega-Alvaro, A. (1996) Preclinical study of a controlled release oral morphine system in rats. Int. J. Pharm. 139: 237-241
4. Alvarez-Fuentes, J., Holgado, M. A., Fernández-Arévalo, M., Rojas, O., Micó, J. A. (1997a) Estudio preliminar para la valoración de un compuesto antagonista opiáceo de liberación controlada. Ind. Farm. 12: 61-68
5. Alvarez-Fuentes, J., Caraballo, I., Boza, A., Llera, J. M., Holgado, M. A., Fernandez-Arevalo, M. (1997b) Study of a complexation process between naltrexone and Eudragit L as an oral controlled release system. Int. J. Pharm. 148: 219-230
6. Carrara, M., Zampiron, S., Capolongo, F., Cima, L., Giusti, P. (1990) Influence of glycine on morphine-induced antinociception in mice. Eur. J. Pharmacol. 179: 301-305
7. Crabtree, B. L. (1984) Review of naltrexone, a long-acting opiate antagonist. Clin. Pharm. 3: 273-280
8. Fuentes, J. A., Ruiz-Gayo, M., Otero, M. J., Vela, G., Reche, I. (1994) Nuevas aproximaciones farmacológicas para la producción de analgesia. Ind. Farm. 9: 51-57
9. Heilman, R. D., Gray, M. I., Chen, R. P., Hann, E. F., Fishman, J. (1976) Evaluation of the hot plate technique to study narcotic antagonist. Res. Commun. Chem. Pathol. Pharmacol. 13: 635-647
10. R L binding interaction. Int. J. Pharm. 114: 13-21
11. International Association for the Study of Pain (IAPS) (1980) Ethical standards for investigations of experimental pain in animals. Pain 9: 141-142
12. Rosland, J. H., Hole, K. (1990) 1,4-Benzodiazepines antagonize opiate-induced antinociception in mice. Anesth. Analg. 71:242-248
13. Verebey, K. (1981) The clinical pharmacology of naltrexone: pharmacology and pharmacochemistry and sustained-release preparations. In: Willette, E., Barnett, G. (eds) NIDA. Research Monograph 28R. U.S. Dept of Health and Human Services, pp 147-158
14. Woolfe, H. G., Macdonald, A. D. (1944) The evaluation of the analgesic action of pethidine hydrochloride. J. Pharmacol. Exp. Ther. 80: 300