Study of a complexation process between naltrexone and Eudragit® L as an oral controlled release system

International Journal of Pharmaceutics

Volumn 148, Issue 2, 1997, Pages 219-230

  Alvarez Fuentes, J ^a   Caraballo, I ^a   Boza, A ^a   Llera, J M ^b   Holgado, M A ^a   Fernandez Arevalo M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b Ctro de Quim Farmaceut   (Cuba)

Author keywords

Controlled release complex; Eudragit L30D; Naltrexone hydrochloride; Preformulation

Indexed keywords

EUDRAGIT; NALTREXONE;

ARTICLE; COMPLEX FORMATION; CONTROLLED RELEASE FORMULATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY;

EID: 0030980510     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04849-1     Document Type: Article

References (20)

1. Alvarez-Fuentes, J., Fernández-Arévalo, M., Holgado, M.A., Caraballo, I., Liera, J.M. and Rabasco, A.M., Morphine polymeric coprecipitates for controlled release: elaboration and characterization. Drug Dei:, lnd. Pharm., 20 (1994a) 2409-2424.
2. Alvarez-Fuentes, J., Fernândez-Arévalo, M., Holgado, M.A., Caraballo, I., Liera, J.M., and Rabasco, A.M., Characteri-zation of morphine polymeric coprecipitates. A biophar-maceutical study. Pharmazie, 49 (1994b) 834-839.
3. Blumberg, H. and Dayton. H.B., Naloxone, naltrexone and related noroxymorphones. Advances in Biochemical Psy-cliopharmacology, Vol. 8, Raven Press, New York, 1974, p. 33.
4. Bogardus, J.B., Common ion equilibria of hydrochloride salts and the Setschenow equation. J. Pharm. Sei., 71 (1982) 588-590.
5. Botha, S.A. and Letter, A.P., Compatibility study between atenolol and tablet excipients using differential scanning calorimetry. Drug Dei: Ind. Pharm., 16 (1990) 1945-1954.
6. Breitmaier, E. and Voelter, W., Carbon-n-NMR Spectroscopy, VCH, Weinheim, 1987.
7. El Egakey, M.A. and Speiser, P., Drug loading studies on ultrafine solid carriers by sorption procedures. Pharm. Acta HeIv., 51 (1982) 236-240.
8. Fernândez-Arévalo, M., Holgado, M.A., Alvarez-Fuentes, J., Caraballo, I., Vela, M.T. and Rabasco A.M., Water-insol-uble complexes of morphine and carteolol-Eudragit® L. A comparative study of the complexation process. Proc. I3th Pharm. Technol. Conf., Strasbourg 1994, Vol. 3, pp. 158-181.
9. Florence, A.T. and Attwood, D., Physicochemical Principles of Pharmacy, 2nd Edn, McMillan Press Ltd., London, 1988, p. 141.
10. Ford, J.L. and Timmins, P., Pharmaceutical Thermal Analysis, Ellis Horwood, Chichester, 1989, p. 25.
11. Holgado, M.A., Diseno y élaboration de dos sistemas orales de liberacion controlada de clorhidrato de carteolol. Evaluation biofarmacéutica. Tesis Doctoral, Universidad de Sevilla, 1993.
12. Holgado, M.A., Fernândez-Arévalo, M., Alvarez-Fuentes, J., Caraballo, I., Liera, J.M. and Rabasco, A.M., Physical characterization of carteolol: Eudragit binding interaction. Int. J. Pharm., 114 (1995) 13-21.
13. Jackman, L.M., Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, Pergamon Press, Ox-ford, 1962.
14. Jenquin, M.R., Liebowitz, S.M., Sarabia, R.E. and McGinity, J.W., Physical and Chemical factors influencing the release of drugs from acrylic resin films. J. Pharm. Sei., 79(1990) 811-816.
15. Miyazaki, S., Oshiba, M. and Nadai, T., Precaution on use of hydrochloride salts in pharmaceutical formulation. J. Pharm. Sei., 70 (1981) 594-596.
16. Naltrexone Information sheets, Lab. Zambön, S.A., Barcelona.
17. Okhamafe, A.O. and York. P., Thermal characterization of drug/polymer and excipient/polymer interactions in some film coating formulation. J. Pharm. Pharmacol, 41 (1989) 1-6.
18. Park, K., Wood, R.W. and Robinson, J.R., In Langer, R.S. and Wise, D.L. (Eds.), Oral Controlled Release Systems in Medical Applications of Controlled Release, Vol. l, CRC Press, Boca Raton, 1984, p. 159.
19. Signoretti, E.C., De Sena, C., Dell'Utri, A. and Alimonti, S., An investigation into eventual interactions between clenbuterol and some mucolytic drugs by differential scanning calorimetry. Drug Dev. Ind. Pharm., 14 (1988) 1167-1184.
20. Swinyard, E.A., Analgesic and Antipyretics in Remington's Pharmaceutical Sciences, 18th Edn, Mack Publishing, Pennsylvania, 1990, p. 1107.