Oestrogen-receptor-α gene polymorphism affects response in bone mineral density to oestrogen in post-menopausal women

Clinical Endocrinology

Volumn 52, Issue 5, 2000, Pages 581-585

  Ongphiphadhanakul, Boonsong ^a,b   Chanprasertyothin, S ^a   Payatikul, P ^a   Tung, S Sae ^a   Piaseu, N ^a   Chailurkit, L ^a   Chansirikarn, S ^a   Puavilai, G ^a   Rajatanavin, R ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA;

ADULT; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE TURNOVER; DENSITOMETRY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RISK FACTOR;

BONE DENSITY; DRUG ADMINISTRATION SCHEDULE; ESTROGEN REPLACEMENT THERAPY; ESTROGENS, CONJUGATED (USP); FEMALE; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, GENETIC; RECEPTORS, ESTROGEN; TREATMENT OUTCOME;

EID: 0034046554     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2000.00979.x     Document Type: Article

References (18)

1. Cummings, S.R., Browner, W.S., Bauer, D., Stone, K., Ensrud, K., Jamal, S. & Ettinger, B. (1998) Endogenous hormones and the risk of hip and vertebral fractures among older women. New England Journal of Medicine, 339, 733-738.
2. Dawson-Hughes, B., Harris, S.S. & Finneran, S. (1995) Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. Journal of Clinical Endocrinology and Metabolism, 80, 3657-3661.
3. Deng, H.W., Li, J., Li, J.L., Johnson, M., Gong, G., Davis, K.M. & Recker, R.R. (1998) Change of bone mass in post-menopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes. Human Genetics, 103, 576-585.
4. Ettinger, B., Genant, H.K. & Cann, C.E. (1987) Postmenopausal bone loss is prevented by treatment with low-dosage estrogen with calcium. Annals of Internal Medicine, 106, 40-45.
5. Genant, H.K., Lucas, J., Weiss, S., Akin, M., Emkey, R., McNaney-Flint, H., Downs, R., Mortola, J., Watts, N., Yang, H.M., Banav, N., Brennan, J.J. & Nolan, J.C. (1997) Low-dose esterified estrogen therapy: effects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Estratab/Osteoporosis Study Group. Archives of Internal Medicine, 157, 2609-2615.
6. Gennari, L., Becherini, L., Masi, L., Gonnelli, S., Cepollaro, C., Martini, S., Mansani, R. & Brandi, M.L. (1997) Vitamin D receptor genotypes and intestinal calcium absorption in post-menopausal women. Calcified Tissue International, 61, 460-463.
7. Gennari, L., Becherini, L., Masi, L., Mansani, R., Gonnelli, S., Cepollaro, C., Martini, S., Montagnani, A., Lentini, G., Becorpi, A.M. & Brandi, M.L. (1998) Vitamin D and estrogen receptor allelic variants in Italian post-menopausal women: evidence of multiple gene contribution to bone mineral density. Journal of Clinical Endocrinology and Metabolism, 83, 939-944.
8. Han, K.O., Moon, I.G., Kang, Y.S., Chung, H.Y., Min, H.K. & Han, I.K. (1997) Nonassociation of estrogen receptor genotypes with bone mineral density and estrogen responsiveness to hormone replacement therapy in Korean post-menopausal women. Journal of Clinical Endocrinology and Metabolism, 82, 991-995.
9. Howard, G., Nguyen, T., Morrison, N., Watanabe, T., Sambrook, P., Eisman, J. & Kelly, P. (1995) Genetic influences on bone density: physiological correlates of vitamin D receptor gene alleles in premenopausal women. Journal of Clinical Endocrinology and Metabolism, 80, 2800-2805.
10. Huizenga, N.A., De Koper, J.W., Lange, P., Pols, H.A., Stolk, R.P., Burger, H., Grobbee, D.E., Brinkmann, A.O., De Jong, F.H. & Lamberts, S.W. (1998) A polymorphism in the glucocorticoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. Journal of Clinical Endocrinology and Metabolism, 83, 144-151.
11. Khosla, S., Atkinson, E.J., Melton, L.J. III & Riggs, B.L. (1997) Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women. A population based study. Journal of Clinical Endocrinology and Metabolism, 82, 1522-1527.
12. Kobayashi, S., Inoue, S., Hosoi, T., Ouchi, Y., Shiraki, M. & Orimo, H. (1996) Association of bone mineral density with polymorphism of the estrogen receptor gene. Journal of Bone and Mineral Research, 11, 306-311.
13. Mata, P., Lopez-Miranda, J., Pocovi, M., Alonso, R., Lahoz, C., Marin, C., Garces, C., Cenarro, A., Perez-Jimenez, F., de Oya, M. & Ordovas, J.M. (1998) Human apolipoprotein A-I gene promoter mutation influences plasma low density lipoprotein cholesterol response to dietary fat saturation. Atherosclerosis, 137, 367-376.
14. Mizunuma, H., Hosoi, T., Okano, H., Soda, M., Tokizawa, T., Kagami, I., Miyamoto, S., Ibuki, Y., Inoue, S., Shiraki, M. & Ouchi, Y. (1997) Estrogen receptor gene polymorphism and bone mineral density at the lumbar spine of pre-and post-menopausal women. Bone, 21, 379-383.
15. Morrison, N.A., Qi, J.C., Tokita, A., Kelly, P.J., Crofts, L., Nguyen, T.V., Sambrook, P.N. & Eisman, J.A. (1994) Prediction of bone density from vitamin D receptor alleles. Nature, 367, 284-287.
16. Ongphiphadhanakul, B., Rajatanavin, R., Chanprasertyothin, S., Piaseu, N., Chailurkit, L., Sirisriro, R. & Komindr, S. (1998) Estrogen receptor gene polymorphism is associated with bone mineral density in pre-menopausal women but not in post-menopausal women. Journal of Endocrinological Investigation, 21, 487-493.
17. Peacock, M. (1995) Vitamin D receptor gene alleles and osteoporosis: a contrasting view. Journal of Bone and Mineral Research, 10, 1294-1297.
18. Wang, D.G., Fan, J.B., Siao, C.J., Berno, A., Young, P., Sapolsky, R., Ghandour, G., Perkins, N., Winchester, E., Spencer, J., Kruglyak, L., Stein, L., Hsie, L., Topaloglou, T., Hubbell, E., Robinson, E., Mittmann, M., Morris, M.S., Shen, N., Kilburn, D., Rioux, J., Nusbaum, C., Rozen, S., Hudson, T.J. & Lander, E.S. (1998) Large-scale identification, mapping, and genotyping of single-nucleotrde polymorphisms in the human genome. Science, 280, 1077-1082.