Efficient adenovirus-mediated gene transfer to basal but not columnar cells of cartilaginous airway epithelia

Human Gene Therapy

Volumn 7, Issue 8, 1996, Pages 921-931

  Pickles, Raymond J ^a   Barker, Pierre M ^a   Ye, Hong ^a   Boucher, Richard C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL CELL; CELL DAMAGE; COLUMNAR EPITHELIUM; CYSTIC FIBROSIS; EPITHELIUM CELL; EXPRESSION VECTOR; GENE TARGETING; GENE TRANSFER; NONHUMAN; RESPIRATORY EPITHELIUM; TRANSGENE;

EID: 0029941649     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1996.7.8-921     Document Type: Article

References (35)

1. BOUT, A., PERRICAUDET, M., BASKIN, G., IMLER, J., SCHOLTE, B.J., PAVIRANI, A., and VALERIO, D. (1994). Lung gene therapy: In vivo adenovirus-mediated gene transfer to rhesus monkey airway epithelium. Hum. Gene Ther. 5, 3-10.
2. CLARKE, L.L., GRUBB, B.R., GABRIEL, S.E., SMITHIES, O., KOLLER, B.H., and BOUCHER, R.C. (1992). Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science 257, 1125-1128.
3. CRYSTAL, R.G., McELVANEY, N.G., ROSENFELD, M.A., CHU, C., MASTRANGELI, A., HAY, J.G., BRODY, S.L., JAFFE, H.A., EISSA, N.T., and DANEL, C. (1994). Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genet. 8, 42-51.
4. ENGELHARDT, J.F., YANG, Y., STRATFORD-PERRICAUDET, L.D., ALLEN, E.D., KOZARSKY, K., PERRICAUDET, M., YANKASKAS, J.R., and WILSON, J.M. (1993a). Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nature Genet. 4, 27-34.
5. ENGELHARDT, J.F., SIMON, R.H., YANG, Y., ZEPEDA, M., WEBER-PENDLETON, S., DORANZ, B., GROSSMAN, M., and WILSON, J.M. (1993b). Adenovirus mediated transfer of the CFTR gene to the lung of nonhuman primates: biological efficacy study. Hum. Gene Ther. 4, 759-769.
6. GOLDMAN, M.J., YANG, Y., and WILSON, J.M. (1995). Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. Nature Genet. 9, 126-131.
7. GRUBB, B.R., PICKLES, R.J., YE, H., YANKASKAS, J.R., VICK, R.N., ENGELHARDT, J.F., WILSON, J.M., JOHNSON, L.G., and BOUCHER, R.C. (1994). Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 371, 802-806.
8. HERTLE, M.D., DOMINIQUE KUBLER, M., LEIGH, I.M., and WATT, F.M. (1992). Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. J. Clin. Invest. 89, 1892-1901.
9. JOHNSON, L.G., BOYLES, S.E., WILSON, J.M., and BOUCHER, R.C. (1995). Normalisation of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primart human cystic fibrosis airway epithelial cells. J. Clin. Invest. 95, 1377-1382.
10. JOHNSON, L.G., PICKLES, R.J., BOYLES, S.E., MORRIS, J.C., YE, H., ZHOU, Z., OLSEN, J.C., and BOUCHER, J.C. (1996). In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia. Hum. Gene Ther. 7, 51-59.
11. KATKIN, J.P., GILBERT, B.E., LANGSTON, C., FRENCH, K., and BEAUDET, A.L. (1995). Aerosol delivery of a β-galactosidase adenoviral vector to the lungs of rodents. Hum. Gene Ther. 6, 985-995.
12. KEENAN, K.P., COMBS, J.W., and McDOWELL, E.M. (1982a). Regeneration of hamster tracheal epithelium after mechanical injury I. Virch. Arch. 41, 193-214.
13. KEENAN, K.P., COMBS, J.W., and McDOWELL, E.M. (1982b). Regeneration of hamster tracheal epithelium after mechanical injury II. Virch. Archiv. 41, 215-229.
14. KENNAN, K.P., COMBS, J.W., and McDOWELL, E.M. (1982c). Regeneration of hamster tracheal epithelium after mechanical injury III. Virch. Arch. 41, 231-252.
15. KEREM, B.S., ROMMENS, J.M., BUCHANAN, J.A., MARIEWICZ, D., COX, T.K., CHAKRAVARTI, A., BUCHWALD, M., and TSIEN, L.C. (1989). Identification of the cystic fibrosis gene: Genetic analysis. Science 245, 1073-1080.
16. KNOWLES, M.R., HOHNEKER, K., ZHOU, Z., OLSEN, J.C., NOAH, T.L., HU, P., LEIGH, M.W., ENGELHARDT, J.F., EDWARDS, L.J., JONES, K., WILSON, J.M., JOHNSON, L.G., and BOUCHER, R.C. (1995). A double-blind vehicle controlled study of adenoviral vector mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med. 333, 823-831.
17. LEIGH, M.W., KYLANDER, J.E., YANKASKAS, J.R., and BOUCHER, R.C. (1995). Cell proliferation in bronchial epithelium and submucosal glands of cystic fibrosis patients. Am. J. Resp. Cell. Mol. Biol. 12, 605-612.
18. MASTRANGELI, A., DANEL, C., ROSENFELD, M.A., STRATFORD-PERRICAUDET, L., PERRICAUDET, M., PAVIRANI, A., LECOCQ, J.P., and CRYSTAL, R.G. (1993). Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer. J. Clin. Invest. 91, 225-234.
19. MERCER, R.R., RUSSELL, M.L., ROGGLI, V.L., and CRAPO, J.D. (1994). Cell number and distribution in human and rat airways. Am. Resp. Cell. Mol. Biol. 10, 613-624.
20. MITTEREDER, N., YEI, S., BACHURSKI, C., CUPPOLETTI, J., WHITSETT, J.A., TOLSTOSHEV, P., and TRAPNELL, B.C. (1994). Evaluation of the efficacy and safety in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5, 717-729.
21. PICKLES, R.J., GRUBB, B.R., JOHNSON, L.J., YE, H., YANKASKAS, J.R., VICK, R.N., ENGELHARDT, J.F., WILSON, J.M., RANDELL, S.H., and BOUCHER, R.C. (1995). Inefficiency of adenoviral gene transfer to airway epithelia in vivo: Cell phenotype dependent transduction. Pediatr. Pulmonol. Suppl. 19, 75.
22. PILEWSKI, J.M., ENGELHARDT, J.F., BAVARIA, J.E., KAISER, L.R., WILSON, J.M., and ALBELDA, S.M. (1995). Adenovirus-mediated gene transfer to human bronchial submucosal glands using xenografts. Am. J. Physiol. 268, L657-L665.
23. RIORDAN, J.R., ROMMENS, J.M., KEREM, B.S., ALON, N., ROZMAHEL, R., GRZELCZAK, Z., ZIELENSKI, J., LOK, S., PLAVSIC, N., CHOU, J.L., DRUMM, M.L., IANNUZZI, M.C., COLLINS, F.S., and TSUI, L-C. (1989). Identification of the cystic fibrosis gene: cloning and characterisation of complementary DNA. Science 245, 1066-1073.
24. ROMMENS, J.M., IANNUZZI, M.C., KEREM, B.S., DRUMM, M.L., MELMER, G., DEAN, M., ROZMAHEL, R., COLE, J.L., KENNEDY, D., HIDAKA, N., ZSIGA, M., BUCHWALD, M., RIORDAN, J.R., TSUI, L-C., and COLLINS, F.S. (1989). Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245, 1059-1065.
25. SHENK, T., JONES, N., COLBY, W., and FOWLKES, D. (1979). Functional analysis of adenovirus 5 host-range deletion mutants defective for transformation of rat embryo cells. Cold Spring Harbor Symp. Quant. Biol. 44, 367-375.
26. SHIMIZU, T., NISHIHARA, M., KAWAGUCHI, S., and SAKAKURA, Y. (1994). Expression of phenotypic markers during regeneration of rat tracheal epithelium following mechanical injury. Am. Resp. Cell. Mol. Biol. 11, 85-94.
27. ST. GEORGE, J.A., SACKS, C.R., LUKASON, M.J., NICHOLS, M., PETERSON, P.A., VACCARO, C., BAILEY, S., JOHNSON, J., PRATT, B., and WADSWORTH, S.C. (1995). Efficacy of adenoviral vectors in airway epithelium. Pediatr. Pulmonol. Suppl. 12, 151.
28. WICKHAM, T.J., MATHIAS, P., CHERESH, D.A., and NEMEROW, G.R. (1993). Integrins avb3 and avb5 promote adenovirus internalisation but not virus attachment. Cell 73, 309-319.
29. WICKHAM, T.J., FILARDO, E.J., CHERESH, D.A., and NEMEROW, G.R. (1994). Integrin avb5 selectively promotes adenovirus mediated cell membrane permeabilisation. J. Biol. Chem. 127, 257-264.
30. WILMOTT, R.W., WHITSETT, J.A., TRAPNELL, B., WERT, S., BAUGHMAN, R., CUPPOLETTI, J., and TOLSTOHEV, P. (1994). Gene therapy for cystic fibrosis utilizing a replication deficient adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways: A phase I study. Hum. Gene Ther. 5, 1019-1057.
31. WILSON, J.M., ENGELHARDT, J.F., GROSSMAN, M., SIMON, R.H., and YANG, Y. (1994). Gene therapy for cystic fibrosis lung disease using E1-deleted adenoviruses: A phase I trial. Hum. Gene Ther. 5, 501-519.
32. YANG, Y., NUNES, F.A., BERENCSI, K., GÖNCZÖL, E., ENGELHARDT, J.F., and WILSON, J.M. (1994). Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7, 362-369.
33. YEI, S., MITTEREDER, N., WERT, S., WHITSETT, J.A., WILMOTT, R.W., and TRAPNELL, B.C. (1994). In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum. Gene Ther. 5, 731-744.
34. ZABNER, J., COUTURE, L.A., GREGORY, R.J., GRAHAM, S.M., SMITH, A.E., and WELSH, M.J. (1993). Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 1-20.
35. ZABNER, J., COUTURE, L.A., SMITH, A.E., and WELSH, M.J. (1994). Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: Efficiency of adenovirus-mediated gene transfer in vitro. Hum. Gene Ther. 5, 585-593.