Chronic exposure to low-level lead impairs learning ability during aging and energy metabolism in aged rat brain

Archives of Gerontology and Geriatrics

Volumn 30, Issue 3, 2000, Pages 199-213

  Yun, Seong Wook ^a   Lannert, Heinrich ^a   Hoyer, Siegfried ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aging; Brain energy metabolism; Lead; Learning and memory; Rat

Indexed keywords

LEAD;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; ENERGY METABOLISM; LEARNING; MALE; MEMORY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0034045246     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(00)00054-6     Document Type: Article

References (47)

1. Agnati L.F., Benfenati F., Solfrini V. et al. Brain aging and neuronal plasticity. Ann. NY Acad. Sci. 673:1992;180-186.
2. Ames A. III, Maynard K.I., Kaplan S. Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J. Cereb. Blood Flow Metab. 15:1995;433-439.
3. Banks E.C., Ferretti L.E., Shucard D.W. Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology. 18:1997;237-282.
4. Bleeker M.L., Lindgren K.N., Ford P. Differential contribution of current and cumulative indices of lead dose to neuropsychological performances by age. Neurology. 48:1997;639-645.
5. Buttgereit F., Brand M.D. A hierarchy of ATP-consuming processes in mammalian cells. Biochem. J. 312:1995;163-167.
6. Byers R., Lord E. Late effects of lead poisoning on mental development. Am. J. Dis. Child. 66:1943;471-483.
7. Carpenter D.O., Matthews M.R., Parson P.J., Hori N. Long-term potentiation in the piriform cortex is blocked by lead. Cell. Mol. Neurobiol. 14:1994;723-733.
8. Casoli T., Spagna C., Fattoretti P., Gesuita R., Bertoni-Freddari C. Neuronal plasticity in aging: a quantittive immunohistochemical study of GAP-43 distribution in discrete regions of the rat brain. Brain Res. 714:1996;111-117.
9. Chen H.H., Ma T., Ho I.K. Protein kinase C in rat brain is altered by developmental lead exposure. Neurochem. Res. 24:1999;415-421.
10. Cory-Slechta D.A. Lead exposure during advanced age: alterations in kinetics and biochemical effects. Toxicol. Appl. Pharmacol. 104:1990;67-78.
11. Cory-Slechta D.A. Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system function. Annu. Rev. Pharmacol. Toxicol. 35:1995;391-415.
12. Dutschke F., Nitsch R.M., Hoyer S. Short-term mental activation accelates the age-related decline of high-energy phosphates in rat cerebral cortex. Arch. Gerontol. Geriat. 19:1994;43-51.
13. Goyer R.A. Results of lead research: prenatal exposure and neurological consequences. Environ. Health Perspect. 104:1996;1050-1054.
14. Hatanpää K., Isaacs K.R., Shirao T., Brady D.R., Rapoport S.I. Loss of protein regulating synaptic plasticity in normal aging of the human brain and in Alzheimer's disease. J. Neuropathol. Exp. Neurol. 58:1999;637-643.
15. Hayashi M., Yamashita A., Shimizu K. Somatostatin and brain-derived neurotrophic factor mRNA expression in the primate brain: decreased levels of mRNA during aging. Brain Res. 749:1997;283-289.
16. Hirata M., Yoshida T., Miyajima K., Kosaka H., Tabuchi T. Correlation between lead in plasma and other indicators of lead exposure among lead-exposed workers. Int. Arch. Occup. Environ. Health. 68:1995;58-63.
17. Hoyer S., Krier C. Ischemia and the aging brain: studies on glucose and energy metabolism in rat cerebral cortex. Neurobiol. Aging. 7:1986;23-29.
18. Hoyer S. Brain glucose and energy metabolism during normal aging. Aging. 2:1990;245-258.
19. Hoyer S. Age as risk factor for sporadic dementia of the Alzheimer type? Ann. NY Acad. Sci. 719:1994;248-256.
20. Jett D.A., Guilarte T.R. Developmental lead exposure alters N-methyl-D-aspartate and muscarinic cholinergic receptors in the rat hippocampus: an autoradiographic study. Neurotoxicology. 16:1995;7-18.
21. Koh S., Loy R. Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons. Brain Res. 440:1988;396-401.
22. Kuhlmann A.C., McGlothan J.L., Guilarte T.R. Developmental lead exposure causes spatial learning deficits in adult rats. Neurosci. Lett. 233:1997;101-104.
23. Lannert H., Hoyer S. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav. Neurosci. 112:1998;1199-1208.
24. Lindholm D., Castren E., Berzaghi M., Blochl A., Thoenen H. Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain-implications for neuronal plasticity. J. Neurobiol. 25:1994;1362-1372.
25. Markovac J., Goldstein G.W. Picomolar concentrations of lead stimulate brain protein kinase C. Nature. 334:1988;71-73.
26. Mayer G., Nitsch R., Hoyer S. Effects of changes in peripheral and cerebral glucose metabolism on locomotor activity, learning and memory in adult male rats. Brain Res. 532:1990;95-100.
27. Mielke H.W., Reagan P.L. Soil is an important pathway of human lead exposure. Environ. Health Perspect. 106(Suppl 1):1998;217-229.
28. Mooradian A.D. Effect of aging on the blood-brain barrier. Neurobiol. Aging. 9:1988;31-39.
29. Muldoon S.B., Cauley J.A., Kuller L.H. et al. Effects of blood lead levels on cognitive function of older women. Neuroepidemiology. 15:1996;62-72.
30. Murphy K.J., Regan C.M. Low-level exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation. J. Neurochem. 72:1999;2099-2104.
31. Murphy K.J., Fox G.B., Kelly J., Regan C.M. Influence of toxicants on neural cells adhesion molecule-mediated neuroplasticity in the developing and adult animal: persistent effects of chronic perinatal low-level lead exposure. Toxicol. Lett. 82-83:1995;271-276.
32. Nitsch R., Hoyer S. Local action of the diabetogenic drug, streptozotocin, on glucose and energy metabolism in rat brain cortex. Neurosci. Lett. 128:1991;199-202.
33. Prince M. Is chronic low-level lead exposure in early life an etiologic factor in Alzheimer's disease? Epidemiology. 9:1998;618-621.
34. Rafalowska U., Struzyńska L., Dabrowska-Bouta B., Lenkiewicz A. Is lead toxicosis a reflection of altered energy metabolism in brain synaptosomes? Acta Neurobiol. Exp. 56:1996;611-617.
35. Rapp P.R., Kansky M.T., Roberts J.A. Impaired spatial information processing in aged monkeys with preserved recognition memory. Neuroreport. 8:1997;1923-1928.
36. Roberts E.L., Chih C.-P. Age-related alterations in energy metabolism contribute to the increased vulnerability of the aging brain to anoxic damage. Brain Res. 678:1995;83-90.
37. Rothweiler B., Temkin N.R., Dikmen S.S. Aging effect on psychosocial outcome in traumatic brain injury. Arch. Phys. Med. Rehabil. 79:1998;881-887.
38. Schwartz B.S., Lee B.K., Stewart W., Ahn K.D., Springer K., Kelsey K. Association of δ-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers. Am. J. Epidemiol. 142:1995;738-745.
39. Shukitt-Hale B., Mouzakis G., Joseph J.A. Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp. Gerontol. 33:1998;615-624.
40. Singh A.K. Neurotoxicity in rats chronically exposed to lead ingestion: measurement of intracellular concentrations of free calcium and lead ions in resting or depolarized brain slices. Neurotoxicology. 16:1995;133-138.
41. Sterling G.H., O'Neil K., McCafferty M.R., O'Neil J. Effect of chronic lead ingestion by rats on glucose metabolism and acetylcholine synthesis in cerebral cortex slices. J. Neurochem. 39:1982;592-596.
42. van der Staay F.J., van Nies J., Raaijmakers W. The effects of aging in rats on working and reference memory performance in a spatial holeboard discrimination task. Behav. Neural Biol. 53:1990;356-370.
43. Widzowski D.V., Cory-Slechta D.A. Homogeneity of regional brain lead concentration. Neurotoxicology. 15:1994;295-307.
44. Winkel R., Kuhn W., Przuntek H. Chronic intoxication with lead- and sulfur compounds may produce Parkinson's disease. J. Neural Transm. 46:1995;183-187.
45. Yamada K., Nabeshima T. Changes in NMDA receptor/nitric oxide signaling pathway in the brain with aging. Microsc. Res. Tech. 43:1998;68-74.
46. Zaiser A.E., Miletic V. Prenatal and postnatal chronic exposure to low levels of inorganic lead attenuates long-term potentiation in the adult rat hippocampus in vivo. Neurosci. Lett. 239:1997;128-130.
47. Zhao W.F., Ruan D.Y., Xu Y.Z., Chen J.T., Wang M., Ge S.Y. The effects of chronic lead exposure on long-term depression in area CA1 and dentate gyrus of rat hippocampus ion vitro. Brain Res. 818:1999;153-159.