The effects of chronic lead exposure on long-term depression in area CA1 and dentate gyrus of rat hippocampus in vitro

Brain Research

Volumn 818, Issue 1, 1999, Pages 153-159

  Zhao, Wang Fa ^a   Ruan, Di Yun ^a   Xu, Yao Zhong ^a   Chen, Ju Tao ^a   Wang, Ming ^a   Ge, Shao Yu ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Hippocampal slice; Lead; Long term depression; Range of synaptic plasticity; Rat

Indexed keywords

LEAD;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TOMOGRAPHY; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; LEARNING DISORDER; LONG TERM EXPOSURE; LONG TERM POTENTIATION; NERVE CELL PLASTICITY; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; DENTATE GYRUS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; FEMALE; HIPPOCAMPUS; LEAD POISONING; MALE; NEURONAL PLASTICITY; RATS; RATS, WISTAR;

EID: 0033528227     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01207-4     Document Type: Article

References (20)

1. Alkondon M., Costa A.C.S., Radhakrishnan V., Aronstam R.S., Albuquerque E.X. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett. 261:1990;124-130.
2. Altmann L., Weinsberg F., Sveinsson K., Lilienthal H., Wiegand H., Winneke G. Impairment of long-term potentiation and learning following chronic lead exposure. Toxicol. Lett. 66:1993;105-112.
3. Bear M.F. A synaptic basis for memory storage in the cerebral cortex. Proc. Natl. Acad. Sci. USA. 93:1996;13453-13459.
4. Bellinger D., Sloman J., Leviton A., Rabinowitz M., Needleman H.L., Waternaux C. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics. 87:1991;219-227.
5. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
6. Bliss T.V.P., Lomo T.J. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. (London). 232:1973;331-356.
7. Carroll P.T., Silbergeld E.K., Goldberg A.M. Alteration of central cholinergic function by chronic lead acetate exposure. Biochem. Pharmacol. 26:1977;397-402.
8. Christie B.R., Kerr D.S., Abraham W.C. The flip side of synaptic plasticity: long-term depression mechanisms in the hippocampus. Hippocampus. 4:1994;127-135.
9. Cooper G.P., Suszkiw J.B., Manalis R.S. Heavy metals: effects on synaptic transmission. Neurotoxicology. 5:1984;247-266.
10. Cory-Slechta D.A. Relationships between lead-induced learning impairments and changes in dopaminergic(DA), cholinergic(Ach), and glutamatergic(Glu) neurotransmitter system functions. Ann. Rev. Pharmacol. Toxicol. 35:1995;391-415.
11. Dudek S.M., Bear M.F. Homosynaptic long-term depression in area CA1 of the hippocampus and effects of N-methyl-D-aspartate receptor blockade. Neuron. 9:1992;967-975.
12. Lasley S.M., Polain-Curtain J., Armstrong D.L. Chronic exposure to environmental levels of lead impairs in vivo induction of long-term potentiation in rat hippocampal dentate. Brain Research. 614:1993;347-351.
13. Lisman J. A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proc. Natl. Acad. Sci. USA. 86:1989;9574-9578.
14. Manalis R.S., Cooper G.P., Pomeroy S.L. Effects of lead on neuromascular transmission in the frog. Brain Research. 294:1984;95-109.
15. Markovac J., Goldstein G.W. Picomolar concentration of lead stimulate brain protein kinase C. Nature. 334:1989;71-73.
16. Needleman H.L., Gatsonis C.A. Low-level lead exposure and the IQ of children. J. Am. Med. Assoc. 263:1990;673-678.
17. Rice D.C. Lead-induced changes in learning: evidence for behavioral mechanisms from experimental animals studies. Neurotoxicology. 14:1993;167-178.
18. Sibergeld E.K., Adler H.S. Subcellular mechanisms of lead neurotoxicity. Brain Research. 148:1978;451-467.
19. 2+ from intracellular stores. J. Neurophysiol. 77:1997;812-825.
20. Xu Y.Z., Ruan D.Y., Wu Y., Jiang Y.B., Chen S.Y., Shi P. Nitric oxide affects LTP in area CA1 and CA3 of hippocampus in low-level lead-exposed rat. Neurotoxicology and Teratology. 20(1):1998;69-73.