The effect of intrathecal endomorphin-2 on the flexor reflex in normal, inflamed and axotomized rats: Reduced effect in rats with autotomy

Neuroscience

Volumn 98, Issue 2, 2000, Pages 339-344

  Grass, S ^a   Wiesenfeld Hallin, Z ^a   Xu, X J ^a  

^a Div Clin Neurophysiol   (Sweden)

Author keywords

Antinociception; Nerve injury; Neuropathic pain; Opioid; Spinal cord

Indexed keywords

ENDOMORPHIN 2;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; FEMALE; FLEXOR REFLEX; NERVE INJURY; NEUROMODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; AXOTOMY; CARRAGEENAN; FEMALE; INFLAMMATION; INJECTIONS, SPINAL; NOCICEPTORS; OLIGOPEPTIDES; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; SCIATIC NERVE; SELF MUTILATION; SPINAL CORD;

EID: 0034045045     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00116-0     Document Type: Article

References (36)

1. Arnér S., Meyerson B.A. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain. 33:1988;11-23.
2. Bian D., Nichols M.L., Ossipov M.H., Lai J., Porreca F. Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats. Neuroreport. 6:1995;1981-1984.
3. Burford N.T., Tolbert L.M., Sadee W. Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. Eur. J. Pharmacol. 342:1998;123-126.
4. Chapman V., Diaz A., Dickenson A.H. Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br. J. Pharmacol. 122:1997;1537-1539.
5. Coderre T.J., Grimes R.W., Melzack R. Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain. Pain. 26:1986;61-84.
6. Crain S.M., Shen K.F. Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. Trends Pharmacol. Sci. 19:1998;358-365.
7. deGroot J.F., Coggeshall R.E., Carlton S.M. The reorganization of mu-opioid receptors in the rat dorsal horn following peripheral axotomy. Neurosci. Lett. 233:1997;113-116.
8. Dickenson A.H., Sullivan A.F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain. 24:1986;211-222.
9. Faris P.L., Komisaruk B.R., Watkins L.R., Mayer D.J. Evidence for the neuropeptide cholecystokinin as an antagonist of opiate analgesia. Science. 219:1983;310-312.
10. Goldberg I.E., Rossi G.C., Letchworth S.R., Mathis J.P., Ryan-Moro J., Leventhal L., Su W., Emmel D., Bolan E.A., Pasternak G.W. Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J. Pharmacol. exp. Therapeutics. 286:1998;1007-1013.
11. Gong J.H., Strong J.A., Zhang S.W., Yue X., DeHaven R.N., Daubert J.D., Cassel J.A., Yu G.L., Mansson E., Yu L. Endomorphins fully activate a cloned human mu-opioid receptor. FEBS Lett. 439:1998;152-156.
12. Hanks G.W., Forbes K. Opioid responsiveness. Acta anaesthesiol. Scand. 41:1997;154-158.
13. Hosohata K., Burkey T.H., Alfaro-Lopez J., Varga E., Hruby V.J., Roeske W.R., Yamamura H.I. Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor. Eur. J. Pharmacol. 346:1998;111-114.
14. Lee Y.W., Chaplan S.R., Yaksh T.L. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci. Lett. 199:1995;111-114.
15. Martin-Schild S., Gerall A.A., Kastin A.J., Zadina J.E. Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. J. comp. Neurol. 405:1999;450-471.
16. Martin-Schild S., Gerall A.A., Kastin A.J., Zadina J.E. Endomorphin-2 is an endogenous opioid in primary sensory afferent fibers. Peptides. 19:1998;1783-1789.
17. McConalogue K., Grady E.F., Minnis J., Balestra B., Tonini M., Brecha N.C., Bunnett N.W., Sternini C. Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2. Neuroscience. 90:1999;1051-1059.
18. Neil A., Kayser V., Gacel G., Besson J.M., Guilbaud G. Opioid receptor types and antinociceptive activity in chronic inflammation: both kappa- and mu-opiate agonistic effects are enhanced in arthritic rats. Eur. J. Pharmacol. 130:1986;203-208.
19. Ossipov M.H., Lopez Y., Nichols M.L., Bian D., Porreca F. Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury. Neurosci. Lett. 199:1995;83-86.
20. Pierce T.L., Grahek M.D., Wessendorf M.W. Immunoreactivity for endomorphin-2 occurs in primary afferents in rats and monkey. Neuroreport. 9:1998;385-389.
21. Przewlocka B., Mika J., Labuz D., Toth G., Przewlocki R. Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats. Eur. J. Pharmacol. 367:1999;189-196.
22. Puke M.J., Wiesenfeld-Hallin Z. The differential effects of morphine and the alpha 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesthesia & Analgesia. 77:1993;104-109.
23. Schreff M., Schulz S., Wiborny D., Hollt V. Immunofluorescent identification of endomorphin-2-containing nerve fibers and terminals in the rat brain and spinal cord. NeuroReport. 9:1998;1031-1034.
24. Shane R., Wilk S., Bodnar R.J. Modulation of endomorphin-2-induced analgesia by dipeptidyl peptidase IV. Brain Res. 815:1999;278-286.
25. Shi T.J., Cui J.G., Meyerson B.A., Linderoth B., Hokfelt T. Regulation of galanin and neuropeptide Y in dorsal root ganglia and dorsal horn in rat mononeuropathic models: possible relation to tactile hypersensitivity. Neuroscience. 93:1999;741-757.
26. Stanfa L.C., Dickenson A.H. Electrophysiological studies on the spinal roles of endogenous opioids in carrageenan inflammation. Pain. 56:1994;185-191.
27. Stanfa L.C., Sullivan A.F., Dickenson A.H. Alterations in neuronal excitability and the potency of spinal mu, delta and kappa opioids after carrageenan-induced inflammation. Pain. 50:1992;345-354.
28. Stone L.S., Fairbanks C.A., Laughlin T.M., Nguyen H.O., Bushy T.M., Wessendorf M.W., Wilcox G.L. Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. NeuroReport. 8:1997;3131-3135.
29. Wall P.D., Devor M., Inbal R., Scadding J.W., Schonfeld D., Seltzer Z., Tomkiewicz M.M. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain. 7:1979;103-111.
30. Wiesenfeld-Hallin Z., Xu X.J. The role of cholecystokinin in nociception, neuropathic pain and opiate tolerance. Regul. Pept. 65:1996;23-28.
31. Wiesenfeld-Hallin Z., Xu X.J., Hakanson R., Feng D.M., Folkers K. Low-dose intrathecal morphine facilitates the spinal flexor reflex by releasing different neuropeptides in rats with intact and sectioned peripheral nerves. Brain Res. 551:1991;157-162.
32. Xu X.J., Dalsgaard C.J., Wiesenfeld-Hallin Z. Intrathecal CP-96,345 blocks reflex facilitation induced in rats by substance P and C-fiber-conditioning stimulation. Eur. J. Pharmacol. 216:1992;337-344.
33. Xu X.J., Wiesenfeld-Hallin Z. The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats. Pain. 46:1991;223-229.
34. Yamamoto T., Yaksh T.L. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and non-opioid receptors. Anesthesiology. 75:1991;817-826.
35. Zadina J.E., Hackler L., Ge L.J., Kastin A.J. A potent and selective endogenous agonist for the mu-opiate receptor. Nature. 386:1997;499-502.
36. Zhang X., Bao L., Shi T.J., Ju G., Elde R., Hokfelt T. Down-regulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy. Neuroscience. 82:1998;223-240.