Mechanisms mediating substance P-induced contraction in the rat iris in vitro

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 7, 2000, Pages 1861-1870

  Grumann Júnior, Astor ^a   Dias, Marcos Antônio ^a   Alves, Ricardo Vieira ^a   Boteon, Joel E ^a   Calixto, João Batista ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ATROPINE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CALCIUM; CALCIUM CHANNEL; CAPTOPRIL; CARBACHOL; GENISTEIN; GUANETHIDINE; INDOMETACIN; MEPYRAMINE; N(G) NITROARGININE METHYL ESTER; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ 3 RECEPTOR ANTAGONIST; NIFEDIPINE; OMEGA CONOTOXIN SVIB; OSANETANT; PHORBOL; PHOSPHORAMIDON; SAREDUTANT; SENKTIDE; STAUROSPORINE; SUBSTANCE P; TACHYKININ RECEPTOR AGONIST; TETRODOTOXIN; THIORPHAN;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; EXTRACELLULAR CALCIUM; IRIS; MALE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPHINCTER PUPILLAE MUSCLE;

ANIMALS; CALCIUM; CALCIUM CHANNELS; DIFFUSION CHAMBERS, CULTURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; IRIS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHARMACOLOGY; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; SUBSTANCE P;

EID: 0034042861     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Unger W, Tighe J. The response of isolated iris sphincter muscle of various mammalian species to substance P. Exp Eye Res. 1984;39: 677-684.
2. Ueda N, Muramatsu I, Taniguchi Y, Nakanishi S, Fujimara M. Effects of neurokinin A, substance P and electrical stimulation in the iris sphincter. J Pharmacol Exp Ther. 1986;239:494-499.
3. Muramatsu I, Nakanishi S, Fujiwara M. Comparison of the responses to the sensory neuropeptides, substance P, neurokinin A, neurokinin B and calcitonin gene-related peptide and to trigeminal nerve stimulation in iris sphincter muscle of the rabbit. Jpn J Pharmacol. 1987;44:85-92.
4. Beding-Barnekow B, Brodin E, Hakanson R. Substance P, neurokinin A and neurokinin B in the ocular response to injury in the rabbit. Br J Pharmacol. 1988;95:259-267.
5. Bill A, Stjernshantz J, Mandahl A, Brodin E, Nilsson G. Substance P: release on trigeminal nerve stimulation, effects in the eye Acta Physiol Scand. 1979;106:371-374.
6. Santos ARS, Calixto JB. Further evidence for involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. Neuropeptides. 1997;31:381-389.
7. Maggi CA. The mammalian tachykinin receptors. Gen Pharmacol. 1995;26:911-944.
8. Gerard NP, Bao L, Ping HX, Gerard C. Molecular aspects of tachykinin receptors. Peptides. 1993;43:21-35.
9. Butler JM, Powell D, Unger WG. Substance P levels in normal and seasonally denervated rabbit eyes. Exp Eye Res. 1980;30:311-313.
10. Kuwayama Y, Stone RA. Distinct substance P and calcitonin gene-related peptide immunoreactive nerves in guinea pig eye. Invest Ophthalmol Vis Sci. 1987;25:1947-1954.
11. Jones MA, Marfurt CF. Peptidergic innervation of the rat cornea. Exp Eye Res. 1998;66:421-435.
12. 7,9)-SP, abolishes the response to ocular trauma. Experentia. 1984;40:368-369.
13. 2 receptors: a study with selective agonists and antagonists. Regul Pept 1993;44:269-275.
14. 3 receptors in rabbit isolated iris sphincter muscle. Br J Pharmacol. 1997;120:9.3-101.
15. Yoshitomi T, Ishikawa H, Haruno I, Ishikawa S. Effect of histamine and substance P on rabbit and human sphincter muscle. Graefes Arch Clin Exp Ophthalmol. 1995;23.3:181-185.
16. Banno H, Imaizumi Y, Watanabe M. Pharmaco-mechanical coupling in the response to acetylcholine and substance P in smooth muscle of rat iris sphincter. Br J Pharmacol. 1985;85:905-911.
17. Arunlakshana O, Schilds H. Some quantitative uses of drug antagonists. Br J Pharmacol. 1959;14:48-58.
18. Pattacchini R, Barthó L, Maggi CA. Characterization of receptors mediating contraction induced by tachykinins in the guinea-pig isolated common bile duct. Br J Pharmacol. 1997;122:1633-1638.
19. Malfroy B, Liggitt D, McCabe J, et al. Administration of recombinant enkephalinase (neutral endopeptidase) prevents capsaicin-induced miosis in rabbit eye in vivo. J Pharmacol Exp Ther. 1990;252:462-465.
20. Maggi CA, Giachetti A, Dey RD, Said SI. Neuropeptides as regulators of airway function: vasoactive intestinal peptide and tachykinins. Physiol Rev. 1995;75:277-322.
21. Igic R, Erdös EG. Substance P degradation by ocular tissues. Acta Med Sal. 1991;20:15-18.
22. Zhou XF, Livett BG. Substance P increases catecholamine secretion from perfused rat adrenal glands evoked by prolonged field stimulation. J Physiol. 1990;425:321-324.
23. Guard S, Watson SP. Tachykinin receptor types: classification and membrane signalling mechanisms. Neurochem Int. 1991;18:149-165.
24. Beckers HJM, Klooster J, Vresen GFJM, Lamers WPMA. Substance P in rat corneal and iridial nerves: an ultrastructural immunohistochemical study. Ophthalmic Res. 1993;25:192-200.
25. Stone RA, Kuwayama Y, Laties AM. Regulatory peptides in the eye. Experientia. 1987;43:791-800.
26. Wahlested C, Beding B, Exman R, Oksala O, Sterjenschantz J. Calcitonin gene-related peptide in the eye: release by sensory nerve stimulation and effects associated with neurogenic inflammation. Regul Pept. 1986;41:107-115.
27. Krootila K, Uusitalo H, Palkama A. Effect of neurogenic irritation and calcitonin gene-related peptide (CGRP) on ocular blood flow in the rabbits. Curr Eye Res. 1988;7:695-703.
28. Haruno I, Yoshitomi T, Yoshiteru H, Katori M, Ishikawa S. Calcitonin gene-related peptide induced relaxation of rabbit iris dilator muscle. Curr Eye Res. 1996;15:105-110.
29. ++ signalling pathways in intestinal muscle cells. J Pharmacol Exp Ther. 1994;270:236-243.
30. Abraham ST, Rice PJ. Protein kinase C-mediated contractile response of the rat vas deferens. Eur J Pharmacol. 1992;218:243-249.
31. Regoli D, Boudon A, Fauchére JL. Receptors and antagonists for substance P and related peptides. Pharmacol Rev. 1994;46:551-599.
32. 2 receptors in the hamster urinary bladder: in vitro and in vivo characterization. Naunyn Schmiedebergs Arch Pharmacol. 1998;358:293-300.
33. 2+ influx pathways mediate tachykinin receptor-induced contraction in circular muscle of guinea-pig colon. Eur J Pharmacol. 1994;255:9-15.
34. Hata F, Fujita A, Saeki K, Kishi I, Takeuchi T, Yagasaki O. Selective inhibitory effect of calcium channel antagonists on the two components of the neurogenic response of guinea pig vas deferens. J Pharmacol Exp Ther. 1992;263:214-220.
35. +2/Calmodulin-dependent protein kinase II. J Neurochem. 1991;56:294-297.
36. Harrie CM, ?Boonen. Jo GR. Effects of a phorhol ester and staurosporine on electro- and pharmacomechanical coupling in a resistant artery. Eur J Pharmacol. 1991;202:25-32.
37. Kitazono T, Ibayashi S, Nagao T, Kagimayama T, Kitayama J, Fujishima M. Role of tyrosine kinase in serotonin-induced constriction of the basilar artery in vivo. Stroke. 1998;29:494-498.
38. 3 receptor-induced relaxation in rat mesenteric artery. Br J Pharmacol. 1995;116: 2919-2922.
39. Osborne NN, Barnett NL, Herrera AJ. NADPH diaphorase localization and nitric oxide synthetase activity in the retina and anterior uvea of the rabbit eye. Brain Res. 1993;610:194-198.
40. Chuman T, Chuman H, Nobushisa N, Sawada A, Yamamoto R, Wada A. Nitric oxide sensitive and insensitive contractions of the isolated rabbit iris sphincter muscle. Invest Ophthalmol Vis Sci. 1996;37:1437-1443.
41. 1 receptors only. Eur J Pharmacol. 1992;216:327-329.
42. Wang Z, Tung SR, Strichartz GR, Hakanson R. Investigation of the specificity of FK 888 as tachykinin receptor antagonist. Br J Pharmacol. 1994;111:1342-1346.
43. Kunitomo M, Imazuizumi N, Sameshima E, Fujiwara M. Pharmacological analysis of receptors involved in the late tachykininergic contractile response to electrical transmural stimulation in isolated rabbit iris sphincter muscle. Jpn J Pharmacol. 1993: 62:257-261.
44. 3 receptor antagonists. Br J Pharmacol. 1997;122:469-476.
45. Patacchini R, Bartho L, Holzer P, Maggi CA. Activity of SR 142801 at peripheral tachykinin receptors. Eur J Pharmacol. 1995;278: 17-25.
46. 3) receptor antagonist SR 142801 on the human receptor expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther. 1995:274:148-154.
47. Patacchini R, Maggi CA. Tachykinin receptors and receptors subtypes. Arch Int Pharmacodyn. 1995;329:161-184.
48. 2-receptors modulating motor responses of human colonic muscle strips. Br J Pharmacol 1998;124:1321-1327.