Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: Potential for treatment of T cell-mediated diseases

International Immunology

Volumn 12, Issue 4, 2000, Pages 479-486

  Lavie, Gad ^a,b   Meruelo, Daniel ^b   Aroyo, Karin ^a   Mandel, Mathilda ^a  

^a SHEBA MEDICAL CENTER   (Israel)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cytotoxic T lymphocyte; Cytotoxicity; Hypericin; Protein kinase C; Tumor necrosis factor

Indexed keywords

CD8 ANTIGEN; ENZYME INHIBITOR; HYPERICIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPID; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DEPHOSPHORYLATION; EFFECTOR CELL; EXOCYTOSIS; IRRADIATION; L CELL; LYMPHOCYTE MEMBRANE; MOUSE; NONHUMAN; PHOTODYNAMICS; PHOTOSENSITIZATION; PRIORITY JOURNAL; T LYMPHOCYTE; TARGET CELL DESTRUCTION;

EID: 0034042262     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/12.4.479     Document Type: Article

References (39)

1. Meruelo, D., Lavie, G. and Lavie, D. 1988. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc. Natl Acad. Sci. USA 85:5230.
2. Lavie, G., Valentine, F., Levin, B., Mazur, Y., Gallo, G., Lavie, D., Weiner, D. and Meruelo, D. 1989. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc. Natl Acad. Sci. USA 86:5963.
3. Tang, J., Colacino, J. M., Larsen, S. H. and Spitzer, W. 1990. Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses. Antiviral Res. 13:313.
4. Takahashi, I., Nakanishi, S., Kobayashi, E., Nakano, H., Suzuki, K. and Tamaoki, T. 1989. Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. Biochem. Biophys. Res. Commun. 165:1207.
5. Agostinis, P., Vandenbogaerde, A., Donella-Deana, A., Pinna, L. A., Lee, K. T., Goris, J., Merlevede, W., Vandenheede, J. R. and De Witte, P. 1995. Photosensitized inhibition of growth factor-regulated protein kinases by hypericin. Biochem. Pharmacol. 49:1615.
6. De Witte, P., Agostinis, P., Van Lint, J., Merlevede, W. and Vandenheede, J. R. 1993. Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. Biochem. Pharmacol 46:929.
7. Couldwell, W. T., Gopalakrishna, R., Hinton, D. R., He, S., Weiss, M. H., Apuzzo, M. L. and Law, R. E. 1994. Hypericin: a potential antiglioma therapy. Neurosurgery 35:705.
8. Zhang, W., Hinton, D. R., Surnock, A. A. and Couldwell, W. T. 1996. Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report. Neurosurgery 38:587.
9. Hamilton, H. B., Hinton, D. R., Law, R. E., Gopalakrishna, R., Su, Y. Z., Chen, Z. H., Weiss, M. H. and Couldwell, W. T. 1996. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J. Neurosurg. 85:329.
10. Koren, H., Schenk, G. M., Jindra, R. H., Alth, G., Ebermann, R., Kubin, A., Koderhold, G. and Kreitner, M. 1996. Hypericin in phototherapy. J. Photochem. Photobiol. B Biol. 36:113.
11. Thomas, C., MacGill, R. S., Miller, G. C. and Pardini, R. S. 1992. Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase. Photochem. Photobiol. 55:47.
12. Hadjur, C., Jeunet, A. and Jardon, P. 1994. Photosensitization by hypericin: ESR evidence for singlet oxygen and superoxide anion radicals formation in an in vitro model. J. Photochem. Photobiol. B Biol. 26:67.
13. Weiner, L. and Mazur, Y. 1992. EPR studies of hypericin. Photogeneration of free radicals and superoxide. J. Chem. Soc. Perkin Trans. 2:1439.
14. Diwu, Z. and Lown, J. W. 1993. Photosensitization with anticancer agents 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. Free Rad. Biol. Med. 14:209.
15. Degar, S., Lavie, G., Meruelo, D. 1993 Photodynamic inactivation of Radiation Leukemia virus produced from hypericin treated cells. Virology 197:96.
16. Hudson, J. B., Lopez-Bazzocchi, I. and Towers, G. H. 1991. Antiviral activities of hypericin. Antiviral Res. 15:101.
17. Lavie, G., Mazur, Y., Lavie, D. and Meruelo, D. 1994. The chemical and biological properties of hypericin - a compound with a broad spectrum of biological activities. Medicinal Res. Rev. 15:111.
18. Lavie, D., Freeman, D., Bock, H., Fleischer, J., Van Kranenburg, K., Ittah, Y., Mazur, Y., Lavie, G., Liebes, L. and Meruelo, D. 1990. Hypericin, a potential anti-AIDS drug. In Trends In Medicinal Chemistry '90. Proc. XIth Int. Symp. on Medicinal Chemistry, Jerusalem, Israel Pergamon Press, Oxford.
19. Mossman, T. 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunogenet. 21:235.
20. Vitiello, A., Heath, W. R. and Sherman, L. A. 1989. Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes. J. Immunol. 143:1512.
21. Peters, P. J., Borst, J., Ourschot, V., Fukuda, M., Krahenbuhl, O., Tschopp, J., Slot, J. W. and Geuze, H. J. 1991. Cytotoxic lymphocyte-T granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 173:1099.
22. Lowin, B., Hahne, M., Mattman, C. and Tschopp, J. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and fas lytic pathways. Nature 370:650.
23. Meruelo, D., Degar, S., Amari, N., Mazur, Y., Lavie, D., Levin, B. and Lavie, G. Mode of action of hypericin as an antiretroviral agent and other relevant findings. In Chu, C. K. and Cutler, H., eds, Natural Products As Antiviral Agents, p. 91. Plenum Press, New York.
24. Agrawal, M. L., Larkin, H. E., Zaidi, S. I. A., Mukhtar, H. and Oleinick, N. L. 1993. Phospholipase activation triggers apoptosis in photosensitized mouse lymphoma cells. Cancer Res. 53:5897.
25. Gross A., Jockel, J., Wei, M. C. and Korsmeyer, S. J. 1998. Enforced dimerization of Bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 14:3878.
26. Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Gugel, E. A., Dustin, M. L., Springer, T. A. and Shaw, S. 1988. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur. J. Immunol. 18:637.
27. + cytotoxic lymphocytes-T. Eur. J. Immunol. 23:418.
28. Krensky, A. M., Sanchez-Madrid, F., Robbins, E., Nagy, J. A., Springer, T. A. and Burakkoff, S. J. 1983. The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J. Immunol. 131:611.
29. Shimonkevitz, R., Cerottini, J. C. and Macdonald, H. R. 1985. Variable requirement for murine lymphocyte functional antigen-1 (LFA-1) in T cell-mediated lysis depending upon the tissue origin of the target cells. J. Immunol. 135:1555.
30. Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russel, J. H. and Ley, T. J. 1994. Cytotoxic lymphocytes require granzyme B for rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 76:977.
31. Shresta, S., MacIvor, D. M., Heusel, J. W., Russell, J. H. and Ley, T. J. 1995. Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells, Proc. Natl Acad. Sci. USA 92:5679.
32. Gamen, S., Hanson, D. A., Kaspar, A., Naval, J., Krensky, A. M. and Anel, A. 1998. Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. J. Immunol. 161:1758.
33. Anel, A., Buferne, M., Boyer, C., Schmitt-Verhulst, A. M. and Goldsein, P. 1994. T cell receptor induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A. Eur. J. Immunol. 24:2469.
34. O'Shea, J. J., McVicar, D. W., Bailey, T. L., Burns, C. and Smith, M. J. 1992. Activation of human peripheral blood T lymphocytes by pharmacologic induction of protein-tyrosine phosphorylation. Proc. Natl Acad. Sci. USA 89:10306.
35. Ting, A. T., Dick, C. J., Schoon, R. A., Karnitz, L. M., Abraham, R. T. and Leibson, P. J. 1995. Interaction between lck and syk family tyrosine kinases in Fcγreceptor-initiated activation of natural killer cells. J. Biol. Chem. 270:16415.
36. Brown, F. D., Thompson, N., Sakib, K. M., Clark, J. M., Powner, D., Thompson, N. T., Solari, R. and Wakeman, M. J. 1998. Phospholipase D1 localizes to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr. Biol. 8, 835.
37. Vandenabeele, P., Declercq, W., Beyaert, R. and Fiers, W. 1995. Two tumor necrosis factor receptors: structure and function. Trends Cell Biol. 5:392.
38. Diwu, Z. and Lown, J. W. 1990. Hypocrellins and their use in photosensitization. Photochem. Photobiol 52:609.
39. Diwu, Z. 1995. Novel therapeutic and diagnostic applications of hypocrellins and hypericin. Photochem. Photobiol. 61:529.