Genetic changes in the interferon sensitivity determining region of hepatitis C virus during the natural course of chronic hepatitis C

Journal of Medical Virology

Volumn 61, Issue 3, 2000, Pages 303-310

  Maekawa, Shinya ^a   Enomoto, Nobuyuki ^a   Kurosaki, Masayuki ^a   Nagayama, Kazuyoshi ^a   Marumo, Fumiaki ^a   Sato, Chifumi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Direct sequencing analysis; Genetic change; Hepatitis C virus; Interferon; Sensitivity determining region

Indexed keywords

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHRONIC DISEASE; DISEASE ACTIVITY; HEPATITIS C; HEPATITIS C VIRUS; NONHUMAN; SEQUENCE ANALYSIS; VIRAL GENETICS;

AGED; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERONS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; VIRAL PROTEINS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0034040934     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9071(200007)61:3<303::AID-JMV4>3.0.CO;2-F     Document Type: Article

References (30)

1. Chayama K, Tsubota A, Kobayashi M, Okamoto K, Hashimoto M, Miyano Y, Koike H, Kobayashi M, Koida I, Arase Y, Saitoh S, Suzuki Y, Murashima N, Ikeda K, Kumada H. 1997. Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection. Hepatology 25:745-749.
2. Detmer J, Lagier R, Flynn J, Zayati C, Kolberg J, Collins M, Urdea M, Sanchez-Pescador R. 1996. Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched-DNA technology. J Clin Microbiol 34:901-907.
3. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C. 1995. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 96:224-230.
4. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C. 1996. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 334:77-81.
5. Fukuma T, Enomoto N, Marumo F, Sato C. 1998. Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein. Hepatology 28:1147-1153.
6. Gale MJ Jr, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, Polyak SJ, Gretch DR, Katze MG. 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230:217-227.
7. Gale MJ Jr, Blakely CM, Kwieciszewski B, Tan SL, Dossett M, Tang NM, Korth MJ, Polyak SJ, Gretch DR, Katze MG. 1998. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanism of kinase regulation. Mol Cell Biol 18:5208-5218.
8. Garson J, Brillanti S, Whitby K, Foli M, Deaville R, Masci C, Miglioli M, Barbara L. 1995. Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C. J Med Virol 45:348-353.
9. Hino K, Sainokami S, Shimoda K, Iino S, Wang Y, Okamoto H, Miyakawa Y, Mayumi M. 1994. Genotypes and titers of hepatitis C virus for predicting response to interferon in patients with chronic hepatitis C. J Med Virol 42:299-305.
10. Hoofnagle JH. 1994. Therapy of acute and chronic viral hepatitis. Adv Intern Med 39:241-275.
11. Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Sugiura T, Shimotohno K. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci USA 87:9524-9528.
12. Kato N, Lan KH, Ono-Nita SK, Shiratori Y, Omata M. 1997. Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. J Virol 71:8856-8859.
13. Khorsi H, Castelain S, Wyseur A, Izopet J, Canva V, Rombout A, Capron D, Capron JP, Lunel F, Stuyver L, Duverlie G. 1997. Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients. J Hepatol 27:72-77.
14. Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell R, Alter H. 1990. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis of detection of antibody to hepatitis C virus. Hepatology 12:671-675.
15. Kurosaki M, Enomoto N, Marumo F, Sato C. 1993. Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection. Hepatology 18:1293-1299.
16. Kurosaki M, Enomoto N, Murakami T, Sakuma I, Asahina Y, Yamamoto C, Ikeda T, Tozuka S, Izumi N, Marumo F, Sato C. 1997. Analysis of genotypes and amino acid residues 2209-2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy. Hepatology 25:750-753.
17. Magrin S, Fabiano C, Gianguzza F, Cutrera M, Alaimo G, Pagliaro L. 1998. HCV NS5A mutations in Europeans infected by genotype 1b [letter]. Gastroenterology 115:244-245.
18. Martinot P, Marcellin P, Pouteau M, Castelnau C, Boyer N, Poliquin M, Degott C, Descoombes I, LeBreton V, Milotova V, Benhamou J, Erlinger S. 1995. Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotypes are the main and independent prognostic factors of sustained response to interferon alpha therapy in chronic hepatitis C. Hepatology 22:1050-1056.
19. Mita E, Hayashi N, Hagiwara H, Ueda K, Kanazawa Y, Kasahara A, Fusamoto H, Kamada T. 1994. Predicting interferon therapy efficacy from hepatitis C virus genotypes and RNA titer. Dig Dis Sci 39:977-982.
20. Okamoto H, Kojima M, Okada S, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S. 1992a. Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 190:894-899.
21. Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M. 1992b. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: applications to clinical surveys and tracing infectious sources. J Gen Virol 73:673-679.
22. Polyak SJ, McArdle S, Liu SL, Sullivan DG, Chung M, Hofgartner WT. 1998. Evolution of hepatitis C virus quasispecies in hyper-variable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection. J Virol 72:4288-4296.
23. Rispeter K, Mengji L, Zibert A, Wiese M, Mendes de Oliveira J, Roggendorf M. 1998. The "interferon sensitivity determining region" of hepatitis C is a stable sequence element. J Hepatol 29: 352-361.
24. Saito I, Miyamura T, Ohbayashi A, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo Q, Houghton M, Kuo G. 1990. Hepatitis C infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87:6547-6549.
25. Saiz JC, Lopez-Labrador FX, Ampurdanes S, Dopazo J, Forns X, Sanchez-Tapias JM, Rodes J. 1998. The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus. J Infect Dis 177:839-847.
26. Saracco G, Rizzetto M. 1996. Predictors of response to interferon therapy. Dig Dis Sci 41:115-120.
27. Squadrito G, Leone F, Sartori M, Nalpas B, Berthelot P, Raimondo G, Pol S, Brechot C. 1997. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 113:567-572.
28. Tanimoto A, Ide Y, Arima N, Sasaguri Y, Padmanabhan R. 1997. The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast. Biochem Biophys Res Commun 236:360-364.
29. Tong M, El-Farra N, Reikes A, Co R. 1995. Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 332:1463-1466.
30. Zeuzem S, Lee JH, Roth WK. 1997. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology 25:740-744.